Evolution of SARS-CoV-2 neutralizing antibody in an HIV-positive patient with COVID-19COVID-19 HIV 양성 환자에서 SARS-CoV-2 중화 항체의 진화Case Reports Published on 2021-12-012022-09-12 Journal: Journal of the Formosan Medical Association = Taiw [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody antibody production Antiretroviral therapy Clinical course coronavirus COVID-19 patient enzyme-linked immunosorbent assay Enzyme-linked immunosorbent assay (ELISA) HIV infection immune response patient with COVID-19 plaque Plaque reduction assay reached reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibody Severe acute respiratory syndrome Symptoms [DOI] 10.1016/j.jfma.2021.04.010 PMC 바로가기 [Article Type] Case Reports
The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatmentReview article Published on 2021-12-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 치료법, [키워드] Anti-viral antibody production COVID-19 Direct domain early administration Effect Efficacy Evidence Google Scholar greater identify IFN in viral indicated interferon observational study Patient pro-inflammatory interleukin Probiotics randomized trial Registration Result risk SARS-CoV-2 SARS-COV-2 infection Science searched strain systematic review Treatment type I Viral diseases virus Virus diseases virus titer virus titers virus titre Web of Science [DOI] 10.1016/j.clnesp.2021.10.016 [Article Type] Review article
Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trialRandomized Controlled Trial Published on 2021-11-302022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Admission adverse events Anti-inflammatory antibody production approved drug Biology center clinically Corticosteroids COVID-19 death determine disease severity double blind drug Efficacy Ethical approval Ethics evaluate food general endocrinology Hospital stay hospitalised Hospitalised patients HRT HRT. immune response immune tolerance include Infectious diseases Inflammatory biomarker intramuscular mechanical ventilation Medicine mitigate New New Orleans Occurrence Oestradiol outcome Participants Patient peer-reviewed Phase 2 Placebo placebo-controlled primary endpoint Primary outcome progesterone proportion randomised readmission reduce reducing Result Sample size secondary Sex sex steroids & Sponsor Standard of care steroid subjects submitted the WHO therapeutic option therapy Trial university USA was obtained WHO ordinal scale [DOI] 10.1136/bmjopen-2021-053684 PMC 바로가기 [Article Type] Randomized Controlled Trial
Inflammation and Platelet Activation After COVID-19 Vaccines – Possible Mechanisms Behind Vaccine-Induced Immune Thrombocytopenia and ThrombosisCOVID-19 백신 후 염증 및 혈소판 활성화 - 백신 유도 면역 혈소판 감소증 및 혈전증 뒤에 가능한 메커니즘Controlled Clinical Trial Published on 2021-11-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, [키워드] Activation Adenovirus age aggregation antibodies antibody antibody production cascade Coagulation complex Complication component COVID-19 COVID-19 pandemic COVID-19 vaccine CRP E-selectin endothelial Epidemiological study event excessive inflammation Gender groups Head-to-head comparison healthy controls ICAM-1 IL-10 IL-1β IL-6 IL-8 increase in individual Inflammation Inflammatory initial Johnson & Johnson marker mRNA mRNA vaccination mRNA vaccine P-selectin pathogenesis of COVID-19 PF4 Platelet platelet activation platelet factor 4 positive promote proportion Prospective Study provided TGF-β the vaccine threshold thrombin thrombocytopenia Thromboembolic event thrombosis TNF-α TTS vaccinated individual vaccination Vaccine Vaccines Vascular VCAM-1 VITT Whole blood [DOI] 10.3389/fimmu.2021.779453 PMC 바로가기 [Article Type] Controlled Clinical Trial
Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human HealthReview Published on 2021-11-212022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Andrographis paniculata (AP) accumulate AGL andrographolide (AGL) Anti-inflammatory anti-manic anti-microbial antibody production benefit booster classical clinically conditions contribute coronavirus COVID-19 COVID-19 epidemic Dengue develop diabetes disease disorders drugs Ebola effective Enhancing Epidemics fibrosis herbal-chemo remedy Human human diseases immune booster immune disorder Immunity immunomodulating drug immunostimulant in vitro influenza A virus liver lung macrophage activation microbial infection multifunctional neuronal pharmacological plant Pneumonia Protective Secondary Metabolite Side effects tested therapeutic therapy tumors variety viral infection [DOI] 10.3390/molecules26227036 PMC 바로가기 [Article Type] Review
Novel suction-based in vivo cutaneous DNA transfection platformResearch Article Published on 2021-11-052022-10-28 Journal: Science Advances [Category] COVID-19, MERS, SARS, [키워드] absence antibody production applied Chinese correlation demonstrated description DNA DNA uptake DNA vaccine Efficiency Electroporation expression expression patterns GFP histological Host humoral immune response in vivo indicate injection middle modeling moderate notable novel Plasmid platform provide SARS-CoV-2 Specific Strong Therapies tissue injury utility Vaccines [DOI] 10.1126/sciadv.abj0611 PMC 바로가기 [Article Type] Research Article
Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2SARS-CoV-2에 감염된 산모에게서 태어난 신생아의 면역 반응Observational Study Published on 2021-11-032022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 48 hour 48 hours age antibody antibody production arbitrary unit association Birth breastmilk children Clinical outcome cohort study enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated explain exposure exposure to finding Follow-up gestational age IgA IgA antibodies IgA antibody IgG antibodies IgM antibodies IgM antibody immune complex Immune complexes immune response immune responses immune system Importance in utero Infant Infants infected with SARS-CoV-2 Infection infection with SARS-CoV-2 information investigated IQR Italy life male Maternal maternal age measure mother mucosal mucosal immune Neonatal Neonate Newborn objective occurred offspring participant parturition passive immunity Point positive Pregnancy pregnant women prospective cohort study PROTECT provided Receptor binding Receptor binding domain Relevance response Result Rome Saliva salivary SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike secretory IgA serum setting significantly higher significantly increased specific antibodies specific antibody specific IgG antibodies spike-specific antibodies Spike-specific antibody spike-specific IgG stimulate systemic immune response systemic immune responses tested transfer Transmission Umberto vertical transmission vertical virus transmission virus Virus spike virus transmission [DOI] 10.1001/jamanetworkopen.2021.32563 PMC 바로가기 [Article Type] Observational Study
Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 InfectionCOVID-19의 항체 반응 패턴 프로파일링: SARS-CoV-2 감염의 진화에서 스파이크 S1-반응성 IgA 서명Immunology Published on 2021-11-032022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody antibody level antibody production Antibody Response antigens baseline Characteristics Clinical course Clinical management clinical manifestations Clinical outcome Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient detectable diagnosed driver dropped exhibiting First wave heterogeneous IgA IgG IgG level IgM Italy levels of antibodies long-lasting magnitude majority marker Neutralizing Neutralizing activity Neutralizing antibodies pandemic Patient pattern persistence Perspective predict Profiling reactive reflect response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 severity signature spike statistical subsequent the antibody response the disease the SARS-CoV-2 Vaccination strategies VoC [DOI] 10.3389/fimmu.2021.772239 PMC 바로가기 [Article Type] Immunology
Janus kinase inhibitors and major COVID-19 outcomes: time to forget the two faces of Janus! A meta-analysis of randomized controlled trials야누스 키나제 억제제와 코로나19 주요 결과: 야누스의 두 얼굴을 잊어야 할 때! 무작위 대조 시험의 메타 분석Meta-Analysis Published on 2021-11-012022-09-11 Journal: Clinical Rheumatology [Category] SARS, 임상, [키워드] added Adult patients antibody production assigned Baricitinib benefit concerning coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 infection Cytokine storm database death disease ECMO Efficacy Endpoint ENhance evaluate extracorporeal membrane oxygenation global public health In-hospital Inflammatory response inhibitor Jak JAK inhibitor jak inhibitors janus Janus kinase Janus kinase inhibitor Kinase inhibitor Mechanical mechanical ventilation mechanism Meta-analysis Mortality nezulcitinib nightmare outcome outcomes pathophysiologic Patient patients with COVID-19 Randomized controlled trial Randomized controlled trials RCT RCTs reduction in risk risk reduction ruxolitinib searched significant decrease stages Standard of care subject Tofacitinib Treatment [DOI] 10.1007/s10067-021-05884-4 PMC 바로가기 [Article Type] Meta-Analysis
Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin CaseCommunication Published on 2021-10-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Activation Antibody detection antibody production Autoimmune disease Autoimmune diseases CD4+ CD4+ T cell CD8+ T-cell cellular cellular response central memory comparison Consensus COVID-19 COVID-19 vaccination COVID-19 vaccines Crohn’s disease Crohn’s disease evaluated had no humoral humoral immune responses IBD IFNγ immunization Inflammatory bowel disease infliximab information lack monozygotic twin normal observation Patient Prevent receive reduced response responses SARS-CoV-2 second dose Support T-cell immunity treated Treatment twin vaccination Vaccine [DOI] 10.3390/v13112143 PMC 바로가기 [Article Type] Communication