Identification of a Novel Linear B Cell Epitope on the Sao Protein of Streptococcus suis Serotype 2Original Research Published on 2020-07-162023-05-31 Journal: Frontiers in Immunology [Category] Fulltext, 조류인플루엔자, [키워드] B-cell epitope ELISA homology analysis Streptococcus suis surface antigen one synthetic peptide [DOI] 10.3389/fimmu.2020.01492 PMC 바로가기 [Article Type] Original Research
Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2Short Report Published on 2020-07-102022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] Analysis antigenicity B-cell epitope B-cell epitopes BepiPred binding bioinformatics Bioinformatics analysis Biotechnology candidate caused center characterized component computation database Discontinuous epitope Epitope-based vaccine exhibited feature genome sequence Gln HLA binding IEDB immune Infection MHC class MHC class I NCBI nucleocapsid protein outbreak pandemic peptide predict predicted Pro produced Protective protein sequence public health Rapid residue resource Result retrieved SARS-CoV-2 spike Spike protein surface T-cell epitope Thr Vaccine Vaccine development [DOI] 10.1186/s40249-020-00713-3 PMC 바로가기 [Article Type] Short Report
Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine DesignArticle Published on 2020-07-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D Structures addition Analysis antigenic antigenicity B-cell B-cell and T-cell epitopes B-cell epitope composed conserved coronavirus 2 Critical Diagnosis epitope fusion peptide glycosylated highly antigenic immune evasion immunogenic profile immunological profile Immunotherapy IMPROVE knowledge linear linear B-cell epitope mechanism Mutation neutralization overlap pandemic of COVID-19 Point mutation predicted Protein residue resolved respiratory S protein SARS-CoV SARS-CoV S protein SARS-CoV-2 serological significant decrease Structure T-cell epitope the SARS-CoV-2 trimeric trimeric S protein Vaccine Vaccine design Variation [DOI] 10.3390/vaccines8030355 PMC 바로가기 [Article Type] Article
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patientsArticle Published on 2020-06-012022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료법, [키워드] Alter antibodies antibody B-cell B-cell epitope coronavirus COVID-19 convalescent patients COVID-19 patient diagnostic diagnostics elicit fusion peptide help human antibody response identify IgG immunodominant immunogenic linear linear epitope neutralising neutralising antibody overlapping Patient peptides Receptor binding domain Region SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera serological test serology significantly spike glycoprotein Spike protein target targets the SARS-CoV-2 vaccine candidate Vaccine development Vaccines viral infection Virus neutralisation [DOI] 10.1038/s41467-020-16638-2 PMC 바로가기 [Article Type] Article
Towards the design of epitope candidates for Coronavirus 2Research-Article Published on 2020-05-312022-10-28 Journal: Bioinformation [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV acute respiratory distress acute respiratory syndrome alveolar cell antigenicity B-cell B-cell epitope beta coronavirus candidate Care cell entry receptor Comorbidities coronavirus 2 Coronavirus-2 COVID-19 develop disease Elderly patient enzyme epitope infect linear lung pandemic peptide Pneumonia predicted Proteases public health threat SARS-CoV-2 screened selected sequence spike glycoprotein stability syndrome T-cell epitope the spike protein therapy Treatment Vaccine vaccine candidate virus [DOI] 10.6026/97320630016375 PMC 바로가기 [Article Type] Research-Article
A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?Brief Report Published on 2020-05-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] analyzed antigenic antigenicity B-cell epitope Characteristics coronavirus COVID-19 D614G effective evade Evolution of SARS-CoV-2 exhibited host immune system Mutation novel Pathogenesis Phylogenetic analysis Prevent reduced required S gene S glycoprotein S1 domain SARS-CoV-2 SARS-CoV-2 strains sequence serological Spike protein strain subtype Subtypes synonymous Vaccine viral entry virus [DOI] 10.3390/vaccines8020220 PMC 바로가기 [Article Type] Brief Report
Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody TreatmentBrief Report Published on 2020-04-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accounted antibody approach B-cell B-cell epitope China convalescent plasma coronavirus COVID-19 development drift emergence epitope European France Genetic Genome genomic drift immune Immune escape imperative information Mutation Netherlands New pandemic Patient predicted protease reported RNA RNA polymerase SARS Coronavirus SARS-CoV-2 several variant Spike protein Switzerland T-cell epitope the disease Treatment Vaccine Vaccine development variant variants virus [DOI] 10.3390/pathogens9050324 PMC 바로가기 [Article Type] Brief Report
Identification of a novel B-cell epitope in the spike protein of porcine epidemic diarrhea virusResearch Published on 2020-04-032022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 3D structure anorexia antibodies antibody Antisera B-cell epitope BALB/c mice cause characterized demonstrated detect determine Diagnostic method ELISA ENhance epidemic diarrhea epitope Epitopes generate high mortality identification identify IFA immunization immunize immunized mice immunodominant indicated Infection Infectious disease linear mAb monoclonal antibodies monoclonal antibody Neonatal Neutralizing Neutralizing antibodies PEDV peptide polyclonal polyclonal antibodies Protein purified reactivity receptor recognize Recombinant protein Region required residue Result S protein S1 protein Spike protein the spike protein Vaccine design virion virus vomiting was used weight loss were used western blot [DOI] 10.1186/s12985-020-01305-1 PMC 바로가기 [Article Type] Research
Analysis of the Genome Sequence and Prediction of B-Cell Epitopes of the Envelope Protein of Middle East Respiratory Syndrome-CoronavirusArticle Published on 2018-07-012022-10-29 Journal: IEEE/ACM transactions on computational biology and [Category] Coronavirus, MERS, [키워드] 3D structure amino acids sequence analyzed B cell epitope B-cell epitope bioinformatics China conserved database death E protein effective envelope epitope genome sequence highly antigenic Host Human identify IMPROVE Infection lack linear B-cell epitope MERS MERS-CoV Middle East NCBI nucleotide outbreak Pandemics Patient PDB predict predicted prediction Protein PyMol respiratory Sequence analysis significantly South Korea strain triggered Vaccine development was performed were used X-ray [DOI] 10.1109/TCBB.2017.2702588 PMC 바로가기 [Article Type] Article
Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article