Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine ModelReview Published on 2020-11-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome animal animal model betacoronaviruses bovine cause Coronaviral coronavirus CoV CoVs disease dissimilarity Endemic Focusing gastrointestinal disease Gastrointestinal infection Health Host human CoVs knowledge Model Naturally OC43 one health pandemic of COVID-19 respiratory infection review SARS-CoV-2 similarity suggested virus [DOI] 10.3390/pathogens9120991 PMC 바로가기 [Article Type] Review
Immunoinformatic Analysis of SARS-CoV-2 Nucleocapsid Protein and Identification of COVID-19 Vaccine TargetsSARS-CoV-2 뉴클레오캡시드 단백질의 면역정보학적 분석 및 코로나19 백신 표적 식별Immunology Published on 2020-10-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] Alpha Amino acid amino acids B cell B cells betacoronaviruses conserved Coronavirus disease 2019 COVID-19 Critical cross-reactive cross-reactivity determinant disease domain dominant effective epitope Epitopes facilitate focus generate homolog host immune system human coronaviruses identification identify immune response immune responses immunological infect information knowledge Major MHC I MHC II alleles modulate MOST N protein nucleocapsid nucleocapsid protein other coronavirus other coronaviruses predicted PROTECT Region resulting SARS-CoV-2 SARS-CoV-2 N protein sequence sequences severe acute respiratory syndrome coronavirus 2 spike glycoprotein T cell T cell epitope T cell epitopes T cell response T cells target the SARS-CoV-2 Vaccination strategies Vaccine Vaccine design Vaccine development virus [DOI] 10.3389/fimmu.2020.587615 PMC 바로가기 [Article Type] Immunology
The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2Genome Replication and Regulation of Viral Gene Expression Published on 2020-09-162022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome affecting Alpha Amino acid antiviral drug Betacoronavirus betacoronaviruses boost can be used complex coronavirus CoV CoVs Critical decrease displaying domains enzymatic activity enzyme evaluated example Exoribonuclease Frequency Genetic genetics genome replication guanine-N7-methyltransferase In vitro assay MERS-CoV MHV Middle East MONITOR mouse hepatitis virus mRNA mutant mutants Mutation nidovirus nonstructural protein nsp14 Nsps observation occurred phenotype Phenotypes progeny promote Proofreading purified replicase replicate Replication replication fidelity replicative reported respiratory syndrome coronavirus reverse genetics RNA genome RNA synthesis SARS-CoV SARS-CoV-2 sequence identity single mutant subunit Support thought viral RNA synthesis viruses while [DOI] 10.1128/JVI.01246-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
The Challenges of Vaccine Development against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine VectorReviews Published on 2020-09-042022-10-30 Journal: Molecular Biology [Category] COVID-19, [키워드] ADE Administered Amino acid Antibody-dependent enhancement antigenic Antiviral approach betacoronaviruses caused Cell-mediated immune responses challenge Combination conformational changes conservative antigenic determinants coronavirus COVID-19 Dependent determinant development effective elicit enhancement expressing glycosylation help humoral Immunity inactivated induce Infection intranasally MERS-CoV mucosal mucosal immune murine respirovirus new SARS-CoV-2 provide respiratory pathogen respiratory tract risk S-protein Safe SARS-CoV-1 SARS-CoV-2 Sendai virus stimulate targeting the spike protein the vaccine Trial Vaccine vaccine vector vector viral infection Viral protein viral vectors virion [DOI] 10.1134/S0026893320060151 PMC 바로가기 [Article Type] Reviews
Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1Research Published on 2020-08-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] addition Affect Amino acid amino acid residue Analysis Asymptomatic betacoronaviruses C-terminal changes changes in China COVID-19 Deletion Effects experiment expression Gene Expression Genome genome sequence genomic genomic region geographical areas GISAID database global pandemic I-TASSER in viral in vitro indicate innate immune system Interaction interferon-alpha involved MAFFT mechanism MERS-CoV Mutagenesis non-structural protein non-structural proteins nsp1 nucleotide ORF1a ORF1ab overlapping pathogenic Patient pauci-symptomatic polyproteins previous study Protein reduction Regulation Replication reported respiratory responsible Result SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequences SARS-CoV-2 viral strain subjects viral adaptation viral pathogenicity viral replication viral strain was performed Wuhan [DOI] 10.1186/s12967-020-02507-5 PMC 바로가기 [Article Type] Research
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first lookBioinformatics Published on 2020-08-012022-10-29 Journal: RNA (New York, N.Y.) [Category] COVID-19, SARS, [키워드] 3′ UTR 5′ UTR Antiviral betacoronaviruses Complete conservation conserved COVID-19 outbreak curated diagnostic diagnostics element genome region genome regions genome sequence genomic region majority ncRNA predict Region regions reported Rfam RNA RNA genome RNA secondary structure RNA sequence SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 strains secondary structure sequence spreads structurome target the SARS-CoV-2 the SARS-CoV-2 genome the SARS-CoV-2 virus viral genome [DOI] 10.1261/rna.076141.120 PMC 바로가기 [Article Type] Bioinformatics
Epidemiology of paediatric Middle East respiratory syndrome coronavirus and implications for the control of coronavirus virus disease 2019Original Article Published on 2020-07-302022-10-31 Journal: Journal of paediatrics and child health [Category] COVID-19, MERS, [키워드] 95% confidence interval acute respiratory syndrome Asymptomatic asymptomatic infections Betacoronavirus betacoronaviruses children clinical feature communicable diseases coronavirus COVID‐19 COVID‐19 dataset death emerging hospitalisation implication Infection less Middle East Middle East respiratory syndrome Coronavirus occur Odds ratio proportion reported required respiratory syndrome coronavirus Result risk risk factor SARS‐CoV‐2 Saudi Arabia significantly higher significantly lower Surveillance Transmission Virus Disease [DOI] 10.1111/jpc.15014 PMC 바로가기 [Article Type] Original Article
Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 PandemicReview Published on 2020-06-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Betacoronavirus betacoronaviruses bioinformatic analysis caused coronavirus coronavirus disease COVID-19 diagnostic systems drug fatality feature Genome sequencing genomic genomic information Genomics highly pathogenic information MERS MERS-CoV Middle East Molecular epidemiology morbidity outbreak Outbreaks pandemic Pathogenesis Phylogenetic analysis SARS-CoV SARS-CoV-2 Strains syndrome Transmission vaccine candidates [DOI] 10.3390/ijms21124546 PMC 바로가기 [Article Type] Review
Genomic Sequencing and Analysis of Eight Camel-Derived Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Isolates in Saudi ArabiaArticle Published on 2020-06-032022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 2019-nCoV 3D structure Analysis Antibody binding appear B cell betacoronaviruses bioinformatics cause Clustering Complete contribute coronavirus Dromedary camel effective vaccine eight epitope evolutionary relationship exhibited Genome Gulf homology Host Human humans isolate MERS-CoV MERS-CoV genome Middle East Neutralizing antibodies occurred outbreak Phylogenetic analysis predict Region respiratory respiratory syndrome coronavirus SARS-CoV Saudi Arabia selected sequence sequenced severe respiratory illness spike glycoprotein Spike protein strain Strains Vaccine design virus [DOI] 10.3390/v12060611 PMC 바로가기 [Article Type] Article
Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?천산갑은 2019년 신종 코로나바이러스(SARS-CoV-2)의 중간 숙주입니까?Research Article Published on 2020-05-142022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Fulltext, Medicine and Health Sciences, MERS, SARS, 조류인플루엔자, [키워드] 2019 novel coronavirus addition Analysis bat coronavirus bat coronaviruses bats betacoronaviruses black market caused city Complete confirmed case conservation coronavirus Coronaviruses COVID-19 Determining Diseases Epidemiological study facilitate Genome help Host Human humans IMPROVE intermediate hosts Laboratory molecular natural history Novel coronavirus outbreak pandemic pangolin pangolins Phylogenetic analysis precursor Prevention and control recent reduce risk SARS-CoV-2 sick Spectrum suggested Support Surveillance the SARS-CoV-2 two group two groups virus Virus Disease wild animal wild animals wildlife Wuhan Wuhan, China [DOI] 10.1371/journal.ppat.1008421 PMC 바로가기 [Article Type] Research Article