Rational optimization of a human neutralizing antibody of SARS-CoV-2
SARS-CoV-2의 인간 중화 항체의 합리적인 최적화
Article
[키워드] ACE2
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
antibody
Antigen
binding affinities
binding affinity
caused
contribute
coronavirus
coronavirus disease
COVID-19
COVID-19 patients
develop
disrupting
domain
drug
effective
enzyme
Epidemic
heavy chain
higher affinity
host cells
hydrogen
Interaction
molecular dynamics
Molecular dynamics simulation
molecular dynamics simulations
mutant
mutants
Mutation
N501Y
Neutralizing activity
Neutralizing antibodies
neutralizing antibody
paratope residue
polar interactions
provide
RBD
RBD domain
Receptor-binding domain
S protein
SARS-CoV-2
SARS-CoV-2 cell
SARS-CoV-2 infected patients
SARS-CoV-2 S protein
SARS-CoV-2 variant
scanning
Scanning mutageneses.
single B cell
single B cells
the RBD
the receptor-binding domain
therapy
[DOI] 10.1016/j.compbiomed.2021.104550 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.compbiomed.2021.104550 PMC 바로가기 [Article Type] Article