The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article
Biogenesis and architecture of arterivirus replication organellesArticle Published on 2016-04-092022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] analysed arteritis arterivirus biogenesis cell line comparable coronavirus Coronaviruses Correlative light-electron microscopy described electron tomography endoplasmic reticulum membranes equine eukaryotic Express expressed expression groups hepatitis C virus homogenous host cell membrane induce infected cells Infection knowledge membrane curvature Membrane remodelling modulating Nidovirale Nidovirales nidoviruses NSP2 Nsp3 organelle picornavirus polyprotein Protein question Regulatory Replication replication complex replication structures RNA RNA synthesis Structure subset Support thought Three-dimensional electron microscopy Topology transmembrane protein Vesicle viral infection viral RNA synthesis virus viruses [DOI] 10.1016/j.virusres.2016.04.001 PMC 바로가기 [Article Type] Article
Only One Isoform of Drosophila melanogaster CTP Synthase Forms the CytoophidiumDrosophila melanogaster CTP Synthase의 단 하나의 Isoform이 Cytoophidium을 형성합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ATP ATP synthase Author Bacteria biogenesis biological processe biological processes block Cell cell types cells conserved cytoplasm demonstrated different disrupt disrupting dissect distribution DNA and RNA domain Drosophila Drosophila melanogaster ectopic expression embryos energy metabolism enzyme example expression expression profiles form growth human cells identify independent induce isoform locus metabolism Mitochondria mutants Mutation nucleotide nucleotides nucleus organism overexpression provide shown Structure subcellular distribution subcellular structure Synthase synthase gene transcript while yeast [DOI] 10.1371/journal.pgen.1003256 PMC 바로가기 [Article Type] Research Article
Biogenesis and Dynamics of the Coronavirus Replicative StructuresReview Published on 2012-11-212022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association biogenesis cellular membrane complexes coronavirus cytoplasmic detected Dynamics humans Infection infectious agent interior involved knowledge live cell imaging membrane membrane anchoring membrane rearrangements membranes nonstructural protein protein-protein interactions Proteins provided recent replication complex replicative RNA RNA synthesis RNA virus Structure structures Vesicle viral RNA synthesis [DOI] 10.3390/v4113245 PMC 바로가기 [Article Type] Review