Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lungResearch article Published on 2021-12-032022-10-05 Journal: Cell [Category] 비임상, [키워드] anamnestic anamnestic antibody antibody B cells BAL Blood boost Bronchoalveolar lavage COVID-19 declined Delta dependent on Efficacy immune response immunized lower airway lower airways lung mRNA vaccine mRNA-1273 mRNA-1273 vaccine mucosal immunity nasal swabs Neutralizing titer nonhuman primates protection Rapid remained responses rhesus macaque RNA SARS-CoV-2 sgRNA sustained T cell response T cells vaccination virus was reduced [DOI] 10.1016/j.cell.2021.12.002 [Article Type] Research article
[Clinical, radiological, and histopathological features of pulmonary post-COVID syndrome : A form of autoimmune-mediated interstitial lung disease?][폐 포스트 코로나 증후군의 임상적, 방사선학적, 조직병리학적 특징 : 자가면역 매개 간질성 폐질환의 한 형태?]Review Published on 2021-12-012022-09-11 Journal: Der Pathologe [Category] SARS, 치료기술, [키워드] alveolar fibrin Analysis Antigen autoantibodies autoantibody Autoimmune BAL biopsy Bronchoalveolar lavage clinical evaluation collagen Combination Computed tomography connective tissue connective tissue disease COVID-19 CTD develop Diagnosis disease English enrolled evaluate feature FIBRIN fibrosis healthy histopathological histopathological feature Histopathology Hospitalization ILD interstitial interstitial pneumonia lavage long-COVID lung lung involvement lymphocytosis median age MOST Most patients nuclear observé Organizing pneumonia oxygen Patient patients performed persistence pilot study Pulmonary function tests pulse radiological radiological feature reported SARS-CoV‑2 serology severe COVID-19 similarity Symptom syndrome transbronchial Volume while [DOI] 10.1007/s00292-021-01024-6 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection in an Adolescent With X-linked AgammaglobulinemiaX-연관 무감마글로불린혈증이 있는 청소년의 SARS-CoV-2 감염Case Reports Published on 2021-12-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute infection Adolescent agammaglobulinemia Bronchoalveolar lavage change chest scan Course COVID-19 disease erythrocyte sedimentation erythrocyte sedimentation rate febrile Fever fevers high resolution high resolution CT infected with SARS-CoV-2 Mild Mild disease Multiple Nasopharyngeal swab nasopharyngeal swabs raised Remdesivir resolved respiratory respiratory symptoms RT-PCR SARS-CoV-2 sedimentation rate X-linked X-linked agammaglobulinemia [DOI] 10.1097/INF.0000000000003360 PMC 바로가기 [Article Type] Case Reports
Case Reports: Bronchial Mucosal Vasculature Is Also Involved in the Acute Vascular Distress Syndrome of COVID-19Medicine Published on 2021-11-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addressed AVDS BAL bronchial Bronchoalveolar lavage bronchovideoscopy Case report contributes coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pandemic description dry cough Dyspnoea Fever Ground glass opacity highlight induce intrapulmonary Intrapulmonary shunt knowledge mucosa NBI (narrow band imaging) patients patients hospitalized performed Pharyngeal swab Pneumonia pulmonary blood flow repeated RT-PCR SARS-CoV-2 Shunt Symptom target Thoracic two patients Vascular vasculature vessel vessels viral disease [DOI] 10.3389/fmed.2021.710992 PMC 바로가기 [Article Type] Medicine
Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models비활성화된 SARS-CoV-2 백신 접종으로 인한 항체 약화는 붉은털 원숭이 폐렴 모델에서 항체 강화 면역병리학 없이 감염에 대한 보호를 제공합니다Letter Published on 2021-11-212022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] absence acute phase acute respiratory syndrome acute respiratory syndrome coronavirus ADE alveolar anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response Antibody-dependent enhancement bronchioles Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell cellular immunity clinical trial control group coronavirus Coronaviruses elevated epithelial Evidence evidence of humans IL-33 IL-8 immunology immunopathology inactivated Inactivated Vaccines Infection initial MCP-1 MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mild mild to moderate moderate Mucus murine neutralizing antibody NHP no evidence of observation offer passive transfer Pneumonia polyclonal antibodies polyclonal antibody postvaccination preclinical studies preclinical study pulmonary immunopathology reported respiratory Respiratory disease respiratory diseases respiratory syndrome coronavirus rhesus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus subneutralizing antibodies supported transfer Typical vaccination Vaccine virus virus infection [DOI] 10.1080/22221751.2021.2002670 PMC 바로가기 [Article Type] Letter
Bronchoscopic suspect of Herpesvirus infection in critically ill COVID-19 patients: two case reports and brief literature review.Case Report Published on 2021-11-042024-09-04 Journal: Acta bio-medica : Atenei Parmensis [Category] 대상포진, [키워드] Bronchoalveolar lavage COVID-19 Critically ill patient fiberoptic bronchoscopy herpesvirus ICU Pneumonia [DOI] 10.23750/abm.v92iS1.12425 PMC 바로가기 [Article Type] Case Report
1347. Comparison Between SARS-Cov-2, non-SARS-Cov-2 Coronavirus, Influenza and RSV Infections Among Solid Organ Transplant RecipientsPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Bronchoalveolar lavage Characteristics clinical coronavirus defined development evaluated figure Fischer’s exact test ICU ICU admission incidence Infection Influenza log rank test Lower respiratory tract mechanical ventilation Mortality multicenter Nasopharyngeal swab outcome pandemic PCR positive performed pulmonary infiltrate recipient reported respiratory syncytial virus respiratory virus Result retrospective cohort study RSV RSV infection SARS-CoV-2 Secondary infection shown significantly Solid solid organ transplant statistical analysis statistically statistically significant study period Transplant without symptoms [DOI] 10.1093/ofid/ofab466.1539 PMC 바로가기 [Article Type] Poster Abstracts
Peritoneal Administration of a Subunit Vaccine Encapsulated in a Nanodelivery System Not Only Augments Systemic Responses against SARS-CoV-2 but Also Stimulates Responses in the Respiratory Tract나노 전달 시스템에 캡슐화 된 서브 유닛 백신의 복막 투여 SARS-COV-2에 대한 체계적인 반응을 강화 할뿐만 아니라 호흡기에서의 반응을 자극합니다.Article Published on 2021-11-022022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] activated addition adjuvant delivery particles administration Antibody Response Bronchoalveolar lavage chitosan circulating COVID-19 pandemic COVID-19 vaccine demonstrated disease elicited global health Health herd immunity IgA IgG immune responses Immunity immunization immunized mice immunogenicity investigated lung homogenate lung homogenates mass vaccination mice mucosal mucosal immunity neutralizing capacity Particle peritoneal immunization receiving respiratory respiratory tract response SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2-infected patients SARS-CoV-2-specific IgG SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses spike glycoprotein spike-specific T cell Spread stimulate stimulated subunit Subunit vaccine System systemic T cell tract vaccination vaccine candidate [DOI] 10.3390/v13112202 PMC 바로가기 [Article Type] Article
Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia혈액 섬유 세포는 COVID-19 폐렴의 중증도 및 예후와 관련이 있습니다.Clinical Trial Published on 2021-11-012022-08-31 Journal: American journal of physiology. Lung cellular and [Category] MERS, SARS, 바이오마커, 임상, [키워드] BAL Blood Bronchoalveolar lavage CCL2 CD34 CD45 Cell circulating collagen Complete Computed tomography Concentration Control coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia CXCL12 death determine died FGF2 fibrocyte flow cytometry growth growth factor healthy controls Hospitalized hospitalized patients ICU ICU patient ICU Patients Increased increased risk individual intensive care intensive care unit lung Lung CT Lung diseases median median age Patient patients hospitalized Pneumonia poor prognosis Predictive Prognosis quantified severity and prognosis subgroup of patient survivor TGF-β1 the patient transforming growth factor were measured [DOI] 10.1152/ajplung.00105.2021 PMC 바로가기 [Article Type] Clinical Trial
Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit—A Monocentric Retrospective Observational StudyArticle Published on 2021-10-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] analysed Analysis approach aspergillosis Aspergillus BAL Bronchoalveolar lavage Bronchoalveolar lavage (BAL) Characteristics complication of COVID-19 Consensus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19-associated pulmonary aspergillosis (CAPA) criteria Culture defined diagnosed Diagnosis diagnostic evaluate Factor galactomannan (GM) greater ICU incidence increasingly intensive care intensive care unit (ICU) invasive pulmonary aspergillosis (IPA) occurred pandemic Patient PCR performed pulmonary radiological reported retrospective Risk factors second wave significantly higher [DOI] 10.3390/pathogens10111370 PMC 바로가기 [Article Type] Article