Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired PneumoniaCOVID-19 관련 폐렴 및 지역사회 획득 폐렴의 림프구 하위집단 및 사이토카인 분석Research Article Published on 2021-06-122022-09-12 Journal: Journal of Immunology Research [Category] MERS, SARS, 진단, [키워드] 2019 novel coronavirus addition calculated caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical outcome community-acquired pneumonia COVID-19 COVID-19 diagnosis COVID-19 patient cytokine Cytokines disease severity identify IFN independent independent predictor independent predictors Logistic regression lymphocyte lymphocyte subpopulation Lymphocyte subset Lymphocyte subsets lymphopenia Novel coronavirus outbreak Patient patients patients with COVID-19 Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes predict predictor Result SARS-CoV-2 SARS-COV-2 infection severity significantly subset the disease TNF- α [DOI] 10.1155/2021/6657894 PMC 바로가기 [Article Type] Research Article
Relationship between lymphocyte subsets values and C-reactive protein in COVID-19 patients코로나19 환자의 림프구 하위 집합 값과 C 반응성 단백질 간의 관계Article Published on 2021-05-012022-09-11 Journal: Cytometry. Part A : the journal of the Internation [Category] SARS, 바이오마커, [키워드] absolute value absolute values age approach association Blood cells blood sample C-reactive protein Calabria CD16 CD16+ CD19 CD19+ CD3+ CD3+CD4+ CD3+CD8+ CD4+ CD56 CD56+ circulating collected containment measures correlated COVID-19 COVID-19 patient COVID-19 positive patient CRP Department Efficacy enrolled females Infectious disease Infectious diseases Inflammation Italy lymphocyte Lymphocyte subset males median value men negative correlation operator operators Patient patients with COVID-19 positive patients predict protocol ranged relationship response to therapy Sample SARS-CoV-2 specimen strength subset T cell T cells the median Therapeutic treatment therapy Treatment Univariate analysis virus spread WBC White blood cell White blood cells [DOI] 10.1002/cyto.a.24327 PMC 바로가기 [Article Type] Article
The Significance of Phenotyping and Quantification of Plasma Extracellular Vesicles Levels Using High-Sensitivity Flow Cytometry during COVID-19 TreatmentCOVID-19 치료 중 고감도 유세포 분석을 사용한 혈장 세포외 소포 수준의 표현형 및 정량화의 중요성Brief Report Published on 2021-04-272022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD14+ CD146 CD147 CD19 CD19+ CD4+ CD63 CD8+ cell type cell types centrifugation clinical manifestation Concentration Coronavirus infection COVID-19 demonstrated diagnostics differential centrifugation dissemination Effectiveness EVs Exosomes extracellular vesicle Extracellular vesicles Flow flow cytometry high-sensitivity flow cytometry immunostaining Infection Level marker mechanism New Pathogenesis patients with moderate Phenotyping phenotyping extracellular vesicles plasma plasma extracellular vesicles Plasma level Plasma levels progression Quantitative analysis SARS-CoV-2 Severe infection severity Significance significantly increased therapy transfer Vesicle vesicles [DOI] 10.3390/v13050767 PMC 바로가기 [Article Type] Brief Report
Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical OutcomeCellular and Infection Microbiology Published on 2021-04-152022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] absence Activation Admission AUC value CD19 CD3 CD38 CD4 CD8 Cell cells clinical Clinical outcome correlation Course COVID-19 COVID-19 pandemic COVID-19 patients disease disease severity examined Exhaustion expression First wave group help highest HLA-DR hospital hospitalised immune Immune cell immune cells exhaustion immune marker immune parameter immunologic predictors Increased increased expression lymphocyte Lymphocyte subset lymphopenia marker MOST multivariate logistic regression no significant difference observation outcome paralysis parameter Patient patients patients with COVID-19 PD1 Potential biomarker predictor profile proportion relationship risk factor SARS-CoV-2 severe group severity significant decrease significant increase significantly significantly higher significantly increased Slovakia Spread Survivors T-cells the disease [DOI] 10.3389/fcimb.2021.646688 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells내피 전구체의 다차원 단백질체 접근은 CD19 세포로 제한된 KDR의 발현을 보여줍니다Clinical Trial Published on 2021-04-012022-08-31 Journal: Stem cell reviews and reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] absence Abstract approach artificial heart B-lymphocyte B-lymphocytes Bioprosthetic total artificial heart Blood C-kit cadherin candidate cardiovascular disease cardiovascular diseases CD133 CD14 CD19 CD34 CD45 Cell cell population cells cellular circulating circulation classic complementary Cord blood COVID-19 COVID-19 severity Critical critical COVID-19 patient cytometric Cytometry demonstrated described Elimination endothelial Endothelial progenitor cell Endothelial progenitor cells Endothelial progenitors evaluate events expresse expressed expressing expression Flow flow cytometry healthy imaging immature induce involved KDR lead Lineage Lymphocytes marker moderate monocyte Monocytes multidimensional one patient Patient performed Peripheral blood phenotype Population positive cell progenitor progenitor cell progenitor cells proteomic quantified redistribution Restricted Single Cell STEM stem cell stem cells subpopulation subset Subtypes vasculogenesis VE-cadherin VEGFR-2/KDR. [DOI] 10.1007/s12015-020-10062-1 PMC 바로가기 [Article Type] Clinical Trial
Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding PeriodsArticle Published on 2021-03-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Blood CD19 CD4 CD8 Cell change clinically Cohort collected comparable Course COVID-19 COVID-19 case COVID-19 patient determine disease disease severity downregulated downregulation evaluate evaluated expressed HCs healthy control heterogeneity Immune cell Immune profile immune response immune signature immune system mononuclear cell NK cell patients PBMCs Period peripheral profile Prognosis recruited remained reported RNA severe disease shedding submitted subsequent the disease upregulated upregulation viral RNA clearance viral RNA-shedding while [DOI] 10.3390/v13030514 PMC 바로가기 [Article Type] Article
Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain림프구 하위 집합은 스페인의 많은 입원 COVID-19 환자의 사망률을 조기에 예측합니다Article Published on 2021-03-012022-08-31 Journal: Clinical and experimental immunology [Category] MERS, SARS, 바이오마커, [키워드] 95% CI 95% confidence interval A significant reduction added Admission age analysed Analysis Blood CD16 CD19 CD3 CD4 CD56 CD8 Cell Chain Reaction China clinical feature co-morbidities co-morbidity consecutive patient COVID-19 COVID-19 patient COVID-19 patients death Deceased demographic died electronic medical records flow cytometry Follow-up Frequency Hospital admission hospitalized COVID-19 patient In-hospital death in-hospital mortality independent independent of information Logistic regression analysis lymphocyte lymphocyte subpopulation Lymphocyte subsets Lymphocytes lymphopenia marker medical records Mild morbidities Mortality multivariate multivariate logistic regression analysis natural killer Older organization Patient peripheral Peripheral blood polymerase chain polymerase chain reaction predict Prognosis Prognostic factor Prognostic factors Registered risk SARS-CoV-2-infected patient SARS-CoV-2-infected patients significantly higher significantly increased Spain Spanish statistical analysis subset survivor T cell T cells tested was performed [DOI] 10.1111/cei.13547 PMC 바로가기 [Article Type] Article
Immune reactivity during COVID-19: Implications for treatmentCOVID-19 동안의 면역 반응성: 치료에 대한 시사점Review Published on 2021-03-012022-09-11 Journal: Immunology letters [Category] MERS, SARS, 바이오마커, 신약개발, 임상, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome affected Antigen appear ARDS best C reactive protein cardiovascular comorbidities cardiovascular comorbidity CD19 cells characterized clinical Clinical symptoms clinical trial clinical trials Coagulopathy contribute convalescent plasma Corticosteroids cough COVID-19 COVID-19 patients Critical CRP Cytokine storm D-dimer disease drug therapy dysregulation Eosinopenia expression fatigue Fever focus helping hematological hematological parameter HLA-DR Host immune response human leukocyte antigen IL-6 IL-6 receptor immune immune dysregulation immune reactivity immune response Immunoglobulin immunological immunological reactivity immunosenescence Immunotherapy in-hospital mortality include Inflammatory response Intravenous immunoglobulin intubation IVIG Laboratory laboratory findings laboratory indexes. lead leukocyte Lymphocytes lymphopenia Macrophage macrophage activation syndrome Mild natural killer occur pathogenic mechanism pathogenic mechanisms Patient patients with COVID-19 predict procalcitonin prognostic biomarker Prognostic biomarkers Prognostic value receptor antagonist reduced reduction respiratory distress Respiratory distress syndrome SARS-CoV-2 severe COVID-19 severity severity of illness symptoms of COVID-19 syndrome T cell T cell response target Therapeutic strategies therapy Tocilizumab trajectory Treatment [DOI] 10.1016/j.imlet.2021.01.001 PMC 바로가기 [Article Type] Review
Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis임상 단계가 다른 COVID-19 환자의 혈액 세포, 림프구 하위 집합 및 사이토카인의 차이점: 네트워크 메타 분석Meta-Analysis Published on 2021-02-082022-08-31 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, meta-analysis, [키워드] 95% CI Analysis Blood blood cell Blood cells CD19 CD3 CD4 CD8 Cell Clinical stages conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients cytokine Cytokines database determine difference elevated Guidance IL-10 IL-1β IL-6 immune Immune suppression Inflammatory inflammatory parameter Injury lymphocyte Lymphocyte subset Lymphocyte subsets mean difference Meta-analysis mild patients network Network meta-analysis neutrophil Patient patients performed Platelet progression Result searched severe and critical patients severity significantly significantly lower Spread Stata supplementary material susceptible cell the disease the mean Treatment WBC were used white White blood cell worsening [DOI] 10.1186/s12879-021-05847-9 PMC 바로가기 [Article Type] Meta-Analysis
Influence of delaying ocrelizumab dosing in multiple sclerosis due to COVID-19 pandemics on clinical and laboratory effectivenessCOVID-19 대유행으로 인한 다발성 경화증에서 ocrelizumab 투여 지연이 임상 및 실험실 효과에 미치는 영향Article Published on 2021-02-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] MERS, 진단, [키워드] age B cell B cells CD19 clinical consequence COVID COVID-19 Cytometry database Delay disability disease EDSS Effect Effectiveness evaluate Flow independent influence Laboratory Linear regression analysis lockdown lymphocyte multiple sclerosis multivariable Ocrelizumab Pandemics Patient phenotype progression repopulation. searched Sex shown status therapy Treatment [DOI] 10.1016/j.msard.2020.102704 PMC 바로가기 [Article Type] Article