cellular receptor – Page 6 – Communicable Diseases Research

Thromboembolic Complications of SARS-CoV-2 and Metabolic Derangements: Suggestions from Clinical Practice Evidence to Causative Agents

Review

Published on 2021-05-252022-10-30
Journal: Metabolites [Category] COVID-19,

Current Strategies of Antiviral Drug Discovery for COVID-19

Molecular Biosciences

Published on 2021-05-132022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] 3CL pro accessory proteins acute respiratory syndrome anti-coronavirus activity antibody anticipated antiviral agent antiviral drug antiviral drugs antiviral strategy approved artificial intelligence asymptomatic infection betacoronaviruses can be used catalytic site cause cellular receptor China circulating Clinical effect common cold conserved Coronaviridae coronavirus COVID-19 COVID-19 disease COVID-19 epidemic current deaths develop direct-acting antiviral disease drug Drug discovery drugs drugs targeting effort ENCODE engage enzyme etiological agent fatality Genome genomic sequence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Helicase High Throughput Screening highlight host-targeting antiviral identify immuno-regulator in viral in vitro in vivo include infections Infectious disease involved Jin membrane MERS MERS-CoV Mild monoclonal antibodies morbidity and mortality Neurological disease neutralizing antibody new treatment strategy non-structural protein outbreak pandemic pandemic disease Papain-like protease peptides phenotypic Prevent previous study protease public health RdRP recognize Region Remdesivir Replication reported respiratory syndrome coronavirus RNA virus RNA-dependent RNA polymerase SARS CoV SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe pneumonia severity shown similarity spike glycoprotein strain Strategy structural protein structural proteins Structure target the disease the epidemic the SARS-CoV-2 Transcription treating COVID-19 upper respiratory tract urgency US FDA viral entry viral infections viral infectious disease WHO World Health Organization
[DOI] 10.3389/fmolb.2021.671263 PMC 바로가기 [Article Type] Molecular Biosciences

Innate immune sensing of coronavirus and viral evasion strategies

Review Article

Published on 2021-05-062022-10-31
Journal: Experimental & Molecular Medicine [Category] COVID-19, SARS,

[키워드] activated acute respiratory syndrome animal hosts Antiviral antiviral immune responses approach caused cellular receptor components coronavirus Coronavirus infections coronavirus protein Coronaviruses COVID-19 Critical cytokine Defense evade function Health Host host immune responses host immunity Human illnesses immune evasion immune sensing immune system Improved Infection infections Innate innate immune response innate immune system interferons (IFNs Invasion Japan knowledge mechanism MERS Middle East Mortality Mutation Organisms pathogen patients Pattern recognition receptors positive-sense receptor respond response resulting RNA virus SARS-CoV-2 single-stranded suppress syndrome Therapeutic approach TLR pathway TLR7 TLR7 gene Transmission triggered understanding university virus viruses zoonotic
[DOI] 10.1038/s12276-021-00602-1 PMC 바로가기 [Article Type] Review Article

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article

Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms

피부 및 전신 메커니즘을 통해 통합된 Pernio(Chilblains), SARS-CoV-2 및 COVID 발가락

Review

Published on 2021-04-012022-09-11
Journal: Mayo Clinic proceedings [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting aldosterone angiotensin Angiotensin II angiotensin-converting enzyme 2 Cell cellular receptor characterized chilblain chilblains clinical coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 COVID-19 severity Cutaneous described Direct discrepancy disease Erythema explain explained feature fingers genetics IFN-I IFN-I response immune immune response immunohistochemistry increase in Infection involved Manifestations many case many cases mechanism Mild Mild disease occur Occurrence pandemic Pathogenesis pathway Patient pernio positive pro-inflammatory protease prothrombotic Renin renin-angiotensin-aldosterone system robust SARS-CoV-2 SARS-CoV-2 cell infection searched Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity Sex sex hormone Sex hormones SIGN skin biopsies skin biopsy susceptibility swelling systemic Toe transmembrane Trigger triggered type I interferon Vascular vasospasm viral cellular infection with COVID-19
[DOI] 10.1016/j.mayocp.2021.01.009 PMC 바로가기 [Article Type] Review

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

다학제적 접근 방식으로 SARS-CoV-2–ACE2 수용체 상호작용을 차단하는 후보로서 인간 ACE2 또는 SARS-CoV-2 스파이크 단백질에 결합하는 화합물 식별

Research Article

Published on 2021-03-302022-09-10
Journal: mBio [Category] SARS, 신약개발, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antiviral bind binding block blockade candidate causative agent cause caused cellular receptor Compound compounds coronavirus COVID-19 death demonstrated Diseases Dissociation constant dose-dependent drug Drug development Drug screening dual entry inhibitors enzyme evaluate Evans blue Human human ACE2 identify in vitro Infection Infectious disease inhibitor Interaction interfere Intervention library lifitegrast lumacaftor molecular docking Protein RBD RBD binders RBD-ACE2 receptor Receptor binding domain Registered repurposing respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium spike spike glycoprotein Spike protein SPR surface plasmon surface plasmon resonance targets the RBD the SARS-CoV-2 these compounds VERO-E6 virus was used
[DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Article

Published on 2021-03-252022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 beta-coronavirus bind binding binding affinity binding energy Biochemistry cellular cellular receptor complex Computational biology and bioinformatics Coronaviridae coronavirus coronavirus disease Coronavirus-2 COVID-19 Critical demonstrated drug expressed facilitate functional host cell host cell receptor in silico inhibit Interaction Lung epithelial cells management mechanism membranes Mutation occurred pandemic performed Protein–protein interaction receptor-binding motif responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein spike glycoprotein Spread the receptor-binding domain Treatment viral genome viral infection
[DOI] 10.1038/s41598-021-86380-2 PMC 바로가기 [Article Type] Article

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

Research

Published on 2021-03-252022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘,

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.

Research Article

Published on 2021-03-242022-08-13
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein
[DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article

Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed Peptides

ACE2 설계 펩티드에 의한 SARS-CoV-1/CoV-2 스파이크 단백질의 억제 메커니즘에 대한 조명

Article

Published on 2021-03-222022-09-11
Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제,

[키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinities binding affinity can be used cellular receptor comparable Contact coronavirus COVID-19 COVID-19 pandemic demonstrated domain domains Efficiency enzyme full-length Host host cells human ACE2 Interaction involved kinetic analysis LIGHT mechanism neutralization novel peptide peptides Previous studies previous study protocol responsible route SARS Coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike sequence shedding shown spike Spike protein Spike proteins surface protein the spike protein thermodynamic virus entry virus infection
[DOI] 10.1021/acs.jcim.0c01320 PMC 바로가기 [Article Type] Article