An Ensemble Matrix Completion Model for Predicting Potential Drugs Against SARS-CoV-2Microbiology Published on 2021-07-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against approved drug association associations baseline catastrophic Classifier Clinical treatment clinical trial collected completion Computational drug Computational drug repurposing coronavirus disease COVID-19 database dataset disease drug Effect evaluated facilitate matrix matrix completion Model negative sample observation outbreak persistence Potential provide Regulatory SARS-CoV-2 subsequent Vaccine virus virus-drug association prediction viruses weighted voting ensemble model [DOI] 10.3389/fmicb.2021.694534 PMC 바로가기 [Article Type] Microbiology
Potential Mechanisms of Action of Chinese Patent Medicines for COVID-19: A ReviewPharmacology Published on 2021-07-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action acute respiratory syndrome Anti-inflammatory Antiviral benefit caused China Chinese Chinese patent medicine Clinical efficacy Clinical treatment contagious coronavirus Coronavirus disease 2019 COVID-19 CPM Critical case early stage Epidemic immunoregulation IMPROVE information involved Local Lung injury mechanism Medicine Mild moderate National Health Commission observation organ outbreak Patent pathogenic Pneumonia Potential regulated review SARS-CoV-2 signaling pathways targets TCM therapeutic efficacy Traditional Chinese medicine Treatment [DOI] 10.3389/fphar.2021.668407 PMC 바로가기 [Article Type] Pharmacology
A Comprehensive Review of COVID-19 Virology, Vaccines, Variants, and TherapeuticsCOVID-19 바이러스학, 백신, 변이체 및 치료제에 대한 종합적인 검토Review Published on 2021-07-092022-09-11 Journal: Current medical science [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral therapy basic sciences Care causative pathogen caused Characteristics Clinical treatment Comprehensive coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death demonstrated driving drug Health Health care highlight immunological mechanism Impact increase in Infection infective information leads management management guidelines mutant strain Mutation pandemic professional provided researcher respiratory review SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Strains the vaccine the vaccines Therapeutics Treatment Vaccine Vaccines variant variant strains variants Virology virus [DOI] 10.1007/s11596-021-2395-1 PMC 바로가기 [Article Type] Review
The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2Neuroscience Published on 2021-07-022022-10-31 Journal: Frontiers in Neuroscience [Category] COVID-19, [키워드] acute respiratory syndrome Affect caused Central nervous system clinical symptom Clinical treatment coronavirus Coronavirus disease 2019 COVID-19 deaths Gastrointestinal gastrointestinal system gastrointestinal tract gut microbiota gut- brain axis infected with SARS-CoV-2 Initially MOST nervous system neuroinvasion neurological neurological manifestation Neurological symptom other organs Pandemics pathophysiological mechanism Patient Respiratory system role SARS-CoV-2 SARS-COV-2 infection Symptom System thought Treatment strategies [DOI] 10.3389/fnins.2021.694446 PMC 바로가기 [Article Type] Neuroscience
Complicated pulmonary human coronavirus-NL63 infection after a second allogeneic hematopoietic stem cell transplantation for acute B-lymphocytic leukemia A case report4800 Published on 2021-06-252022-10-30 Journal: Medicine [Category] Coronavirus, MERS, [키워드] acute B-lymphocytic leukemia administration allo-HSCT Allogeneic allogeneic HSCT Alter antiviral therapy body temperature Case report Chest CT Clinical treatment complications Computed tomography coronavirus cough cytokine level death diagnosed Diagnosis diagnostic value DNA and RNA early infection early stage effective exhibited ground-glass opacity HCoV-NL63 high-throughput sequencing of infectious pathogen macrogenome Host HSCT Human human coronavirus NL63 Immunocompromised infecting pathogen Infection Inflammatory leukemia metagenomic Mortality Neutrophil-to-lymphocyte ratio Next-generation sequencing NGS NLR oxygen saturation pathogen Patient post-second allogeneic hematopoietic stem cell transplantation pulmonary lobule returned Sequencing serological test Stem cell transplantation suggested the disease the patient therapy Treatment Treatment outcome underlying disease Viral pneumonia virus [DOI] 10.1097/MD.0000000000026446 PMC 바로가기 [Article Type] 4800
NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative DiseasesReview Published on 2021-06-112022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] ACE Activation acute respiratory syndrome Affect ALS Alzheimer’s disease amplify caused Central nervous system Clinical treatment CNS contagious coronavirus Coronavirus disease 2019 COVID-19 determine disease evaluate explain induce Infectious disease Inflammation Inflammatory Interaction manuscript microglia neurodegenerative Neurodegenerative disease Neuroinflammation nicotinamide adenine dinucleotide NOX2 occur oxidative stress Parkinson’s disease pathogen performed phosphate provided reactive oxygen specy receptor respiratory tract resulting ROS SARS-CoV-2 SARS-COV-2 infection spike Treatment Viral protein [DOI] 10.3390/medicina57060604 PMC 바로가기 [Article Type] Review
International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 CountriesResearch Published on 2021-06-112022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] 95% CI abnormality age analyzed approach available data bimodal C-reactive protein cardiac Cardiac arrhythmia Characteristics characterization checked children clinical Clinical data clinical feature Clinical features Clinical treatment Coagulation Cohort cohort study collected common complement Complication country COVID-19 D-dimer demonstrated Disease activity Disease surveillance distribution EHR elevated Elevation epidemiological female ferritin fibrinogen finding France Germany Health Health care system hospital Hospitalization Hospitalized Importance Infection Infection prevention Inflammation information initial International Laboratory laboratory abnormality Laboratory test male marker mean value measure medication medications MONITOR objective participant Patient pediatric Pediatric patient Pediatric patients Point positive procalcitonin proportion Record Relevance Respiratory failure Result retrospective cohort study SARS-CoV-2 SARS-CoV-2 infections setting Singapore Spain tested treated trend Variability Viral pneumonia with COVID-19 Youth [DOI] 10.1001/jamanetworkopen.2021.12596 PMC 바로가기 [Article Type] Research
Effects of respiratory training on pulmonary function, bad mood, and quality of life in patients with COVID-19 A protocol for systematic review and meta-analysisCOVID-19 환자의 폐 기능, 나쁜 기분 및 삶의 질에 대한 호흡기 훈련의 영향 체계적인 검토 및 메타 분석을위한 프로토콜4400 Published on 2021-06-112022-08-31 Journal: Medicine [Category] COVID-19, MERS, meta-analysis, [키워드] carried Clinical treatment clinical trials computer conducted conferences Controlled coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 data extraction database Effect Ethical approval Ethics evaluate the effect Evidence Evidence-based medicine IMPROVE life limit Lung function mental health Meta-analysis OSF Patient patients with COVID-19 peer-reviewed present protocol Pulmonary function Quality of life Registration registration number required researcher respiratory respiratory training searched social media social media platforms submitted systematic review was performed was used Web of Science [DOI] 10.1097/MD.0000000000026154 PMC 바로가기 [Article Type] 4400
Liver injury in COVID-19: clinical features and treatment managementCovid-19의 간 손상 : 임상 특징 및 치료 관리Review Published on 2021-06-092022-09-10 Journal: Virology Journal [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Clinical characteristics clinical feature Clinical treatment coronavirus Coronavirus-2 country COVID-19 Injury Liver injury Lung disease management Pathogenesis patients respiratory SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Severe case severe cases spread to Treatment [DOI] 10.1186/s12985-021-01593-1 PMC 바로가기 [Article Type] Review
Antibody Responses and the Effects of Clinical Drugs in COVID-19 PatientsCOVID-19 환자에서 항체 반응과 임상 약물의 효과Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Affiliated Hospital Anti-RBD IgG anti-viral drug Anti-viral drugs antibody Antibody titer Arbidol Bilirubin Chloroquine clinical Clinical treatment collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed direct bilirubin disease drug Effect ELISA Epidemic epidemic disease glucocorticoid Host humoral Humoral response humoral responses hydroxybutyrate dehydrogenase IgG and IgM IgM antibodies Infection Inflammatory responses laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lymphocyte Patient peripheral lymphocyte plasma plasma sample plasma samples Protein Protein subunit RBD Receptor binding domain reduced response Ritonavir SARS-CoV-2 SARS-CoV-2 nucleic acid serum severe symptom severe symptoms significantly Specific specific antibodies specific antibody Spike protein subunit suggested Sun Yat-sen therapy total bilirubin university while α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/fimmu.2021.580989 PMC 바로가기 [Article Type] Immunology