CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot StudyRandomized Controlled Trial Published on 2022-06-012022-10-04 Journal: Critical Care Medicine [Category] 임상, [키워드] 1:1 95% CI adjusted Adsorption adverse event age Antibiotics Berlin C-reactive protein clinical concentrations control group Controlled COVID-19 COVID-19 patient COVID-19 patients cytokine dose Effect Endpoint enrolled excluded Gender greater groups hazard ratio Hemodialysis ICU IMPROVE inflammatory markers interleukin-6 interquartile range IQR junction measurement median membrane Monmouth Mortality mortality rate Multiple one patient Patient pilot study primary endpoint Prospective Randomized receive reduction Registered registry rescue Resolution secondary Secondary endpoints Shock Standard of care Standard therapy study inclusion the primary endpoint treatment group university hospital variable Withdrawal [DOI] 10.1097/CCM.0000000000005493 PMC 바로가기 [Article Type] Randomized Controlled Trial
Anakinra treatment efficacy in reduction of inflammatory biomarkers in COVID-19 patients: A meta-analysisCOVID-19 환자에서 염증성 바이오마커 감소에 대한 아나킨라 치료 효능: 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute-phase reactant Admission Anakinra analyzed anti-inflammatory agent C-reactive protein C-reactive protein (CRP Care Cochrane Central concentrations conducted COVID-19 COVID-19 patients CRP CRP value CRP values D-dimer database dimer Efficacy elevated ferritin Follow-up hematological Inflammatory Inflammatory biomarker inflammatory biomarkers interleukin interleukin-1 Laboratory males Manger marker mean difference mean value Meta-analysis notable Patient Protein reduce mortality reduced reduction review SARS-CoV-2 serum Serum ferritin SMD statistically the mean Treatment treatment of COVID-19 patients trials Web of Science [DOI] 10.1002/jcla.24434 PMC 바로가기 [Article Type] Meta-Analysis
Humoral response to SARS-CoV-2 vaccines in people living with HIVHIV 감염자의 SARS-CoV-2 백신에 대한 체액 반응Article Published on 2022-06-012022-09-12 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjusted Analysis anti-SARS-CoV-2 antibody anti-SARS-CoV-2-antibody antibody antibody concentration Antibody Response association CD4 CD4 cell comparative statistics Concentration concentrations COVID-19 COVID-19 vaccine COVID-19 vaccines cumulative electronic patient file Factor female Generalized Germany HIV humoral immune response Humoral response identify IQR Linear model logit magnitude males median mRNA vaccine Munich PLWH quartiles robust SARS-CoV-2 SARS-CoV-2 vaccine significantly subjects threshold vaccination variable were used with HIV [DOI] 10.1007/s15010-021-01721-7 PMC 바로가기 [Article Type] Article
Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS methodFavipiravir(SARS-CoV-2) 분해 불순물: LC/LC-MS 방법을 사용하여 완성된 고체 제형의 분해 메커니즘 식별 및 경로Article Published on 2022-06-012022-09-11 Journal: Biomedical chromatography : BMC [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile Analysis analyte approved buffer column temperature Compound concentrations condition country Degradation degradation impurities, favipiravir, LC/LC-MS, related substances, SARS-CoV-2, stability indicating. dosage Emergency use Favipiravir flow rate Forced harmonization HPLC identification injection International Conference LC-MS limit linear linearity mechanism Mobile molecular pathway performed physical Precision Quality control quantification reaction recovery study Research research and development robust SARS-CoV-2 SARS-CoV-2 patients separation stability Standard deviation stationary stationary phase stress conditions supported tablets temperature treat Volume water [DOI] 10.1002/bmc.5363 PMC 바로가기 [Article Type] Article
Differences in SARS-CoV-2-Specific Antibody Responses After the First, Second, and Third Doses of BNT162b2 in Naïve and Previously Infected Individuals: A 1-Year Observational Study in Healthcare ProfessionalsBNT162b2 1차, 2차, 3차 접종 후 SARS-CoV-2 특이 항체 반응의 차이Observational Study Published on 2022-05-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료법, [키워드] addition age Analysis Anti-nucleocapsid antibodies anti-nucleocapsid antibody anti-S anti-S antibody anti-S antibody dynamics Anti-spike antibody concentration BMI BNT162b2 BNT162b2 vaccine booster Concentration concentrations COVID-19 Critical determine difference different time point dose doses effective vaccine Effective vaccines first dose hcp healthcare Healthcare professional healthcare professionals humoral immune response humoral immune responses immune responses increase in individual infected individual infected individuals Infection median median value naïve naïve individual naïve individuals of BNT162b2 omicron predictor professional Protective response Safe SARS-CoV-2 second second dose sera Sex significant difference significant differences significantly Spread statistically steadily decreased systemic adverse event systemic adverse events vaccination vaccination schedule Vaccine variant variants of SARS-CoV-2 were used [DOI] 10.3389/fimmu.2022.876533 PMC 바로가기 [Article Type] Observational Study
Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In VivoMolnupiravir 및 활성 형태인 EIDD-1931, 시험관 내 및 생체 내 엔테로바이러스 감염에 대한 강력한 항바이러스 활성을 나타냄Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] 치료제, [키워드] active form activity administration Analysis Antiviral antiviral drug approved aseptic meningitis children Concentration concentrations COVID-19 death disease drug candidate EIDD-1931 EIDD-2801 Encephalitis enterovirus expression foot form hand Health authority indicated Infant Infants Infection infections mechanism Meningitis mice molnupiravir myocarditis plasma drug potent progeny reduce reducing reported show significantly state Treatment treatment of COVID-19 United Kingdom various tissue various tissues Viral load Viral protein virus [DOI] 10.3390/v14061142 PMC 바로가기 [Article Type] Article
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine stormFamotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.Article Published on 2022-05-162022-09-11 Journal: Molecular Medicine [Category] 유전자 메커니즘, [키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR [DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment잠재적인 COVID-19 치료제로서 생쥐에서 흡입된 이버멕틴의 약동학 및 안전성Article Published on 2022-05-102022-09-11 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] administration analyzed Antiviral antiviral efficacy BALB/c mice BALF binding Bronchoalveolar lavage fluid clinically collected Concentration concentrations COVID-19 Critical drug Dry Dry powder aerosol Formulation healthy histological in vitro in vitro experiment Inhalable ivermectin inhalation Inhaled intratracheal administration investigated Ivermectin kidney Lactose less limit limitation liver Local low dose lung Lungs mice Mild overcome pharmacokinetic pharmacokinetics plasma Protein Protein binding resolved respiratory tract Safety SARS-CoV-2 spleen spray Spray drying therapeutic Toxicity Treatment viral pathology was used [DOI] 10.1016/j.ijpharm.2022.121688 PMC 바로가기 [Article Type] Article
Possible therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19: A pilot randomized, double-blind, clinical trialResearch article Published on 2022-05-012022-10-05 Journal: Journal of trace elements in medicine and biology [Category] 임상, [키워드] biochemical parameter Boron Boron citrate clinical trial Combination Concentration concentrations cough COVID-19 COVID-19 patients diagnosis of COVID-19 double-blind erythrocyte sedimentation rate fatigue four group group groups hemoglobin High-sensitivity C-reactive protein IMPROVE interleukin-1β Lymphocyte count medications myalgia O2 Saturation Oleoylethanolamide Patient patients with COVID-19 Placebo Platelet post-intervention PPAR-α Randomized recruited reduction in respiratory rate Result SARS-CoV-2 serum interleukin-6 levels serum lactate Shortness of breath significant decrease significant difference significant increases in significantly symptoms of COVID-19 therapeutic effect Therapies Treatment were assessed White blood cell [DOI] 10.1016/j.jtemb.2022.126945 [Article Type] Research article