Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro ) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidatesBrief Report Published on 2020-04-092022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 100% conserved 2019-nCoV 3C-like protease 3CL 3CL pro Antiviral binding candidate cleavage site conserved Coronaviral coronavirus COVID-19 drug Drug repurpose effective enzyme Enzymes fatigue HCV hepatitis C virus identity inhibitory action involved ledipasvir molecular Molecular modelling New coronavirus ortholog performed polyprotein prediction protease residue reveal SARS SARS-CoV SARS-CoV-2 sequence Side effects specific inhibitor specificity the SARS-CoV-2 velpatasvir Virtual screening [DOI] 10.12688/f1000research.22457.2 PMC 바로가기 [Article Type] Brief Report
Lithium and coronaviral infections. A scoping review.Brief Report Published on 2020-04-032022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV Antiviral antiviral activity Apoptosis approach Chloroquine Community Coronaviral Coronaviridae coronavirus coronavirus disease COVID-19 disorder glycogen synthase kinase 3-beta GSK-3β identify in vitro study Infection infections lithium lithium carbonate lithium orotate Novel coronavirus rapid response Research SARS-CoV-2 shown Spread the SARS-CoV-2 treat Wuhan [DOI] 10.12688/f1000research.22299.2 PMC 바로가기 [Article Type] Brief Report
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and PerspectiveReview Published on 2020-03-152022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV analyzed causative pathogen China Chinese clinical evidence Compound Coronaviral coronavirus 2 Coronavirus pneumonia COVID-19 patient current drug Epidemiology experiment greater homology Infection introduced lethal disease mechanism Medicine non-specific outbreak Pathogenesis patients with SARS Pneumonia receiving respiratory review SARS-CoV SARS-CoV-2 SARS-CoV-2 infected patient Spread supportive care Symptom TCM the patient the SARS-CoV-2 therapeutic effect Therapies Traditional traditional Chinese medicine (TCM) Treatment Vaccine [DOI] 10.7150/ijbs.45538 PMC 바로가기 [Article Type] Review
Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) InfectivityEditorial Published on 2020-02-192022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect affected affecting cause China computational tool Coronaviral coronavirus country COVID-19 death disorder Epidemic evaluated health emergency Infection infections Infectivity intrinsic laboratory-confirmed LIGHT membrane protein MERS MERS-CoV Middle East Model New coronavirus nucleocapsid protein outbreak predisposition protein intrinsic disorder respiratory syndrome coronavirus rigidity SARS-CoV Shed shell shell disorder Spread the WHO Transmissibility Transmission Viral proteins virulence WHO World Health Organization Wuhan-2019-nCoV [DOI] 10.3390/biom10020331 PMC 바로가기 [Article Type] Editorial
Discovery and Characterization of Novel RNA Viruses in Aquatic North American Wild BirdsArticle Published on 2019-08-212022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] Ana Analysis avian viruses Bird calicivirus characterization Co-infection collected Complete Coronaviral coronavirus distributions Genome Host indicated knowledge métapneumovirus North novel Novel viruses RNA RNA virus sequenced suggested Swab viral epidemiology Viral reservoir virus virus discovery was determined [DOI] 10.3390/v11090768 PMC 바로가기 [Article Type] Article
Coronavirus envelope protein: current knowledgeReview Published on 2019-05-272022-10-28 Journal: Virology Journal [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] acute respiratory syndrome assembly budding Coronaviral coronavirus CoV CoV protein CoVs Critical cross demonstrated effective envelope protein function Good high mortality rate highlighting host cell Human human CoV humans infect infecting Infection Interaction involved knowledge mammal mechanism membrane protein MERS Molecular biology motif outbreak Pathogenesis Protein Proteins recent Research SARS-CoV E shown syndrome Topology Transmission vaccine candidates viral life cycle Viral protein viroporin [DOI] 10.1186/s12985-019-1182-0 PMC 바로가기 [Article Type] Review
From SARS to MERS, Thrusting Coronaviruses into the SpotlightReview Published on 2019-01-142022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] acute respiratory syndrome animal model animal models caused contributing to Coronaviral coronavirus Coronaviruses CoV CoVs develop Diseases Epidemiology Host host receptor human populations humans International mechanism MERS MERS-CoV Middle East mortality rate outbreak pathogen Pathogenesis pathogenic pathogenicity prevention and treatment provide Research respiratory pathogen respiratory syndrome coronavirus respiratory tract infection S proteins SARS-CoV Spike proteins the spike protein Treatment viruses zoonotic CoV [DOI] 10.3390/v11010059 PMC 바로가기 [Article Type] Review
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labelingResearch Article Published on 2019-01-112022-10-31 Journal: eLife [Category] Coronavirus, MERS, [키워드] assist Biotin breadth build caused Cell common cold Complete complex complexes comprehensive analysis Contact Coronaviral coronavirus Coronaviruses Critical cytoplasm demonstrated Determination disease enzyme Factor Factors genetic code help Host host cell host cells host protein host proteins Human infect Infection infections Interaction involved kill knowledge membrane MERS microenvironment Mild molecular mouse nose and throat Other Pathways platform positive-sense RNA virus Protein proximal proximity labeling question replicase complex replication complex researcher RNA virus RTC scientist severe disease short-lived starting point Symptom target therapeutic intervention These viruses translation translation initiation Transport turn Vesicular Transport Viral proteins viral RNA synthesis virus virus infection virus particles Virus-host interaction waste disposal [DOI] 10.7554/eLife.42037 PMC 바로가기 [Article Type] Research Article
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese batsArticle Published on 2018-09-122022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Analysis animal model bat bats Brain carried changes China Chinese collected conserved Coronaviral coronavirus CoVs Cross-species transmission disease Europe genetic diversity Genome genomic identity Microscopy nucleotide Open reading frame ORFs outbreak pathogenic PCR amplification Perspective Protein provided RdRP reservoirs SARS Coronavirus SARS-CoV SARS-like coronavirus SL-CoV SL-CoVs virus Virus-like particle Zhejiang [DOI] 10.1038/s41426-018-0155-5 PMC 바로가기 [Article Type] Article
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral ActivityArticle Published on 2017-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activities activity approach block cells cellular combination treatment Compound Comprehensive Coronaviral Coronaviruses dominant effective feasible host cell Infection inhibit inhibition inhibitor IκBα Jak JAK2 mechanisms Mediated MERS-CoV NF-κB NF-κB activation p65 pathway Pathways Phosphorylation pro-inflammatory response Regulation Replication SARS-CoV target targeting TGEV Treatment viral infection Viral RNA virus [DOI] 10.1038/s41598-017-04203-9 PMC 바로가기 [Article Type] Article