SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodiesSARS-CoV-2-특이 기억 B 세포는 검출 가능한 중화 항체를 상실한 노인에서 지속될 수 있습니다Research Article Published on 2022-01-182022-09-10 Journal: The Journal of Clinical Investigation [Category] 변종, 진단, 치료기술, [키워드] activated Adaptive immunity affinity age antibody antigenic antigenic stimulation Asymptomatic asymptomatic infection B cell Care classical Cohort COVID-19 COVID-19 outbreak detectable domain ELISPOT enzyme Frequency functional defect highlight immune Immunity immunoglobulins immunology in some individual Inflammation majority MBC MBCs median age memory B cell memory B cells Mild NAb NAbs neutralize Neutralizing antibodies neutralizing antibody persist phenotype proportion RBD recall Receptor-binding domain reduced remained reserve S1 subunit SARS-COV-2 infection significantly spike Spike protein spike- survived variant viruses was selected [DOI] 10.1172/JCI152042 PMC 바로가기 [Article Type] Research Article
Humoral and cellular immunity in convalescent COVID-19 people with multiple sclerosis treated with ofatumumab오파투무맙으로 치료받은 다발성 경화증 환자의 회복기 COVID-19 환자의 체액 및 세포 면역Article Published on 2022-01-152022-09-11 Journal: Journal of neuroimmunology [Category] 임상, 진단, [키워드] Administered all subject all subjects antibodies Antibody Response Antibody testing CD19 CD19+ Cell cellular immunity Clinical outcome convalescent COVID-19 COVID-19 infection COVID-19 symptoms COVID-19 vaccination COVID-19 vaccinations dose ELISPOT four subject humoral IgG antibodies IgG antibody IgM IgM and IgG Immunity interferon interferon-γ lymphocyte mediated immunity Mild Multiple multiple sclerosis not performed Ofatumumab PCR performed Quotient reactive SARS-CoV-2 secreting single center subject T cell T-cell T-cell immunity Testing treated U/mL was performed was used while [DOI] 10.1016/j.jneuroim.2021.577788 PMC 바로가기 [Article Type] Article
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19β-NGF/TrkA 신호 전달 경로는 회복기 COVID-19에서 항핵단백질 IgG의 생산과 관련이 있습니다Immunology Published on 2022-01-142022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] β-NGF age analysed antibody antibody production Asymptomatic CD4 convalescent correlated COVID-19 Cytokines defined discrepancy ELISPOT expressed Factor First wave flow cytometry high variability Host IC50 IFN-γ IgG IgG level IL-1α Infection Inflammation mild SARS-CoV-2 infection molecular mechanism neutralising antibody pandemic pathway PBMC PCR-confirmed peptides positive positive correlation Production receptor Regulation reported Result SARS-CoV-2 SARS-COV-2 infection selected serum severe COVID-19 shown significantly specific antibody subject subjects T cell T cells titre undetectable virus-specific T cell Volunteer was determined were measured while [DOI] 10.3389/fimmu.2021.813300 PMC 바로가기 [Article Type] Immunology
Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection생존한 고령 환자들은 SARS-CoV-2 감염 후 수개월 동안 세포 및 체액 면역학적 기억이 보존됨을 보여줍니다Article Published on 2022-01-072022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-N antibodies anti-N antibody anti-N IgG anti-S anti-S IgG antibodies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determined by donors effective ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Fewer patient Fewer patients granzyme B had more heterogeneity hospital Humoral response IFN-γ IgG1 immune responses Immunity Immunological memory immunosenescence in some infected individuals Infection interferon interferon-γ life lymphocyte Lymphocytes memory memory B memory B cell memory B cells memory B lymphocytes memory T memory T lymphocytes Month Older pandemic Patient Peripheral blood positively correlated preserved producer cell quantified recovered patient reduce resolved respiratory respond response responses robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom show Specific specific antibodies specific immunity T lymphocyte T lymphocytes understanding Vaccination strategies virus were measured [DOI] 10.1093/gerona/glab206 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults젊은 스웨덴 성인에 대한 인구 기반 연구에서 SARS-CoV-2에 특이적인 B 및 T 세포 면역Clinical Trial Published on 2022-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age allergy assessment Asthma Asymptomatic asymptomatic infections Barn binding domain birth cohort body mass body mass index cellular immunity Characteristics Cohort conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease detectable disease Effects ELISA ELISPOT Factor Follow-up Health humoral humoral and cellular immunity IgA IgE IgG IgG titer IgG titers IgM Immunity IMPROVE indicate individual Infection memory B memory B cells memory response memory T memory T cells Mild mild to moderate mild to moderate disease milieu moderate disease participant population-based cohort positive public transport respiratory rhinitis risk Risk factors SARS-CoV-2 SARS-COV-2 infection seronegative seropositive seropositive subject Seropositivity severe acute respiratory syndrome Coronavirus Sex smoking specific IgM subject subjects subpopulation subset Swedish Symptom symptomatic and asymptomatic T cells T-cell T-cell immunity T-cell Response T-cell responses Transport vaccination whom young adults [DOI] 10.1016/j.jaci.2021.10.014 PMC 바로가기 [Article Type] Clinical Trial
Off-the-Shelf Partial HLA Matching SARS-CoV-2 Antigen Specific T Cell Therapy: A New Possibility for COVID-19 Treatment기성품 부분 HLA 매칭 SARS-CoV-2 항원 특이적 T 세포 요법: COVID-19 치료를 위한 새로운 가능성Immunology Published on 2021-12-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] adoptive transfer Antigen approach assays both groups CD4+ T cell CD56 CD8+ Cell Characteristics COVID-19 COVID-19 patient COVID-19 patients COVID19 Culture cytokine cytotoxicity determined by donors effector memory ELISPOT feature Final functional generate groups HLA HLA sharing hyperinflammation IL-2 Immunity immunophenotype in both group individual intracellular cytokine lymphopenia matching membrane mononuclear cell mononuclear cells New Nucleocapsid proteins Partial peptide Peripheral blood Peripheral blood mononuclear cells profiles rationale reduced respond Result SARS-CoV-2 SARS-CoV-2 antigen severe COVID-19 patient severe COVID-19 patients Specific specificity stimulated subset T cell T cell responses T cell therapy T cells transfer treat Treatment viral immunity virus specific T cells was determined [DOI] 10.3389/fimmu.2021.751869 PMC 바로가기 [Article Type] Immunology
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course AnalysisObservational Study Published on 2021-12-092022-10-04 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] addition Admission Analysis Bacterial sepsis Cell cellular circulating Clinical outcome clinical outcomes Cohort Course COVID patient Critically ill patient dyscrasia elevated ELISPOT enzyme-linked immunospot assay etiology Ex vivo exhibited expression functional healthy control HLA-DR hospitalized patient IFN-gamma immune immune response Immune suppression immunological Immunosuppression incidence Infection Inflammation Inflammatory marker initial less leukocyte MDSC mononuclear cell organ dysfunction patients physiologic derangement plasma biomarker reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient secondary bacterial infection Secondary infection secondary infections severe SARS-CoV-2 significantly higher subjects suffered suppressed time TNF-alpha [DOI] 10.3389/fimmu.2021.792448 PMC 바로가기 [Article Type] Observational Study
Comparison of the Development of SARS-Coronavirus-2-Specific Cellular Immunity, and Central Memory CD4+ T-Cell Responses Following Infection versus VaccinationArticle Published on 2021-12-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition assays BNT162b2 CD4+ CD4+ T-cell CD4+ T-cells cellular immunity central memory comparable coronavirus COVID-19 cytokine development effector memory elicited ELISPOT flow cytometric Frequency induce Infection Level marker memory Memory T-cells proportion response SARS-CoV-2 SARS-COV-2 infection severe disease significantly lower T-cell T-cell immune response T-cell Response vaccination [DOI] 10.3390/vaccines9121439 PMC 바로가기 [Article Type] Article
Performance of the T-SPOT Ⓡ.COVID test for detecting SARS-CoV-2-responsive T cellsSARS-CoV-2 반응성 T 세포 검출을 위한 T-SPOT Ⓡ.COVID 검사 성능Article Published on 2021-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] Activation Adaptive immune response anti-N IgG Blood common cold common cold coronavirus control group coronavirus COVID-19 cross-reactive detect Diagnosis ELISPOT evaluate IGRA Immunoglobulin Infection interferon interferon-gamma release assay less methodology NAAT nucleic acid nucleic acid amplification nucleic acid amplification test nucleocapsid participant Participants participants with SARS-CoV-2 Patient peptides performance performed reactive response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serology serology test seropositive T cell T cell response T cell responses T cells T-cell T-cells T-SPOT.COVID [DOI] 10.1016/j.ijid.2021.09.073 PMC 바로가기 [Article Type] Article
Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People고령자에서 BNT162b2 mRNA 백신 2회 접종 후 SARS-CoV-2에 대한 기능적 T-세포 반응 손상Comparative Study Published on 2021-11-162022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Adults Affect alteration analyzed antibody Antibody Response antibody response against Antibody titer baseline BNT162b2 vaccine CD4 CD8 Cell cellular collected coronavirus COVID-19 infection dose Efficiency ELISPOT flow cytometry Frequency functional greater high plasma level Humoral immunity IFNγ IgG IL-2 immune response Immunity Immunocompromised Impaired injection Long-term care median age memory response mRNA mRNA vaccination mRNA-based vaccines neutralizing antibody neutralizing antibody titers of BNT162b2 Older older people and ageing parameter participant Participants physiological postvaccination quantified response SARS – CoV – 2 SARS-CoV-2 Specific T-cell response subjects suggested T cell T cells T cells response T-cell T-cell responses TNFα vaccination Vaccine vaccine responses [DOI] 10.3389/fimmu.2021.778679 PMC 바로가기 [Article Type] Comparative Study