A COVID moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopyArticle Published on 2021-04-152022-10-30 Journal: Journal of Biomolecular Nmr [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral therapeutics assist binding complement Compound coronavirus coronavirus disease COVID COVID-19 drug design effective effort enzymatic activity etiological group information inhibitor inhibitors International Interpretation Ligand M pro MPro molecular dynamics NMR NMR spectroscopy nuclear performed protease protocol SARS-CoV-2 SARS-CoV-2 main protease STD supplementary material the SARS-CoV-2 therapeutic target These data transfer viral replication [DOI] 10.1007/s10858-021-00365-x PMC 바로가기 [Article Type] Article
NSP16 2′-O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments StrategiesReview Published on 2021-03-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 2′-O-MTase activate affecting Animal host binding conserved coronavirus deaths Degradation disease enzymatic activity eukaryotic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Host host immunity human coronavirus human coronaviruses humans infect infecting infections information life-threatening mechanism MERS-CoV mRNA mutant strain nonstructural protein 16 Novel coronavirus nsp10 prevention problem PROTECT Protein provide public health SARS-CoV SARS-CoV-2 Seven Strategy Therapeutic approach Treatment treatment strategy upper respiratory tract variety virus [DOI] 10.3390/v13040538 PMC 바로가기 [Article Type] Review
Inhibition of HECT E3 ligases as potential therapy for COVID-19COVID-19에 대한 잠재적 치료제로서의 HECT E3 리가제의 억제Article Published on 2021-03-242022-09-11 Journal: Cell Death & Disease [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료제, [키워드] activating Antiviral effect Biomarker Brassicaceae Cell clinical trial clinical trials compounds COVID-19 COVID-19 infected patient E3 ligase Ebola enzymatic activity family members germline identify implicated infected patients Infection inhibit inhibition inhibitor Interaction Medical genomics Mouse models NEDD4 overexpressed pandemic potential therapy Protein responsible RNA virus SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 spike Spike protein target the cell the SARS-CoV-2 therapeutic strategy Treatment variant variants Viral viruses VP40 WWP1 [DOI] 10.1038/s41419-021-03513-1 PMC 바로가기 [Article Type] Article
Catalytic amplification by transition-state molecular switches for direct and sensitive detection of SARS-CoV-2Research Article Published on 2021-03-172022-10-04 Journal: Science Advances [Category] SARS, 진단, 치료기술, 치료제, [키워드] activated amplification applied approach binding bypasse catalytic clinical samples complexes COVID-19 COVID-19 pandemic demonstrated diagnostics enzymatic activity fluorescence detection implementation molecular nucleic acid Patient PCR processed RNA SARS-CoV-2 swab samples target temperature turn Viral RNA [DOI] 10.1126/sciadv.abe5940 PMC 바로가기 [Article Type] Research Article
Therapeutic Potential of EGCG, a Green Tea Polyphenol, for Treatment of Coronavirus DiseasesCommunication Published on 2021-03-042022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 3CL addition Antiviral Bioavailability cleaved coronavirus coronavirus disease coronavirus diseases Coronaviruses COVID-19 demonstrated EGCG enzymatic activity epigallocatechin gallate Evidence green green tea inhibit interfere maturation polyphenol polyprotein Potential protease regulate Replication reported Research RNA-dependent RNA polymerase SARS-CoV-2 targets tea Treatment viral spike protein [DOI] 10.3390/life11030197 PMC 바로가기 [Article Type] Communication
Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury7-케토콜레스테롤에 의한 내피 손상에 대한 에르고티오네인의 효과Article Published on 2021-03-012022-09-11 Journal: Neuromolecular medicine [Category] 신약개발, [키워드] 7-Ketocholesterol addition animals Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects antioxidant Apoptosis Bacteria blood-brain barrier Blood–brain barrier Brain cardiovascular disease Cell cell viability cholesterol claudin claudin-5 CNS complications coronavirus COVID-19 COX2 cross Cyclooxygenase Cytokines Dementia diabetes diet Diseases dose-dependent Effect Eicosanoids Endothelial cell endothelial cells enzymatic activity Ergothioneine excitotoxicity Extracellular Free Free radicals fungi Human brain humans IL-1β IL-6 IL-8 increase in increases in Incubation induce Inflammation inhibitor management mRNA expression Mushrooms Necrosis neurodegenerative Neuroinflammation neurologic Neurovascular Neutralizing NF-kB nucleus nutraceutical oxidative stress Oxysterols Patient pro-inflammatory cytokines produced protective effect Proteins reduced significantly stroke thought tight junction Tight junction proteins TNF-α unlikely Vascular vascular dementia viability ZO-1 zonula zonula occludens [DOI] 10.1007/s12017-020-08620-4 PMC 바로가기 [Article Type] Article
Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection폴리뉴클레오티드-아데노신 뉴클레오시다아제인 사포린은 SARS-CoV-2 감염에 효과적인 치료제가 될 수 있습니다Article Published on 2021-03-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] 진단, 치료제, [키워드] (rRNA abasic site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine agent Apoptosis Cell characteristic conserved coronavirus Coronavirus 2019 COVID-19 drug efficacious therapeutic enzymatic activity eukaryotic cells focus Genomic DNA high stability Hyperactivation Immunotherapy induce Infection inhibitor N-glycosidase Nucleosidase Pathways polymerase Protein protein synthesis residue respiratory ribosomal RNA RNA rRNA saporin. SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signal transduction Stress stress response therapeutic therapeutic agents toxin Treatment type I [DOI] 10.1177/2472555220970911 PMC 바로가기 [Article Type] Article
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents잠재적인 항 SARS-CoV-2 제제로서의 3-키모트립신 유사 프로테아제(3CLPro) 억제제의 확인Article Published on 2021-01-202022-09-10 Journal: Communications Biology [Category] 신약개발, 치료제, [키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 boceprevir chymotrypsin Combination Coronavirus-2 develop drug drugs enzymatic activity enzyme enzyme activity exhibited FDA approved Drugs High-throughput screening homodimeric identification identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory activity inhibitory effect Ivermectin lack micafungin molecular molecular dynamics Molecular dynamics simulation morbidity ombitasvir outbreak paritaprevir protease public health Replication replication of SARS-CoV-2 respiratory SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral Screening selected severe acute respiratory syndrome Coronavirus simulation studies target targets the SARS-CoV-2 therapy tipranavir Viral was used [DOI] 10.1038/s42003-020-01577-x PMC 바로가기 [Article Type] Article
Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro시험관 내 SARS-CoV-2 바이러스 복제를 억제하는 강력한 활성을 가진 항말라리아 약물인 QuinacrineArticle Published on 2021-01-172022-09-10 Journal: Viruses [Category] 치료제, [키워드] acidic organelles activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anticancer antimalarial antiviral activities antiviral activity antiviral drugs Antiviral effect clinical study Concentration confocal microscopy copy numbers coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutaneous lupus erythematosus cytotoxicity determinate determined by Diseases drug effective electron enzymatic activity evaluate immunomodulator Infection inhibiting modulating MOIs molecule MTT Phospholipase A2 quinacrine raise real-time RT-PCR reduce Replication respiratory rheumatological RNA SARS CoV-2 SARS-CoV-2 SARS-CoV-2 virus shown Strong treated Vero E6 Vero E6 cell VERO E6 cells Viral viral cell viral copy numbers viral cytotoxicity viral DNA virus virus replication was determined were infected [DOI] 10.3390/v13010121 PMC 바로가기 [Article Type] Article
Microsecond MD Simulation and Multiple-Conformation Virtual Screening to Identify Potential Anti-COVID-19 Inhibitors Against SARS-CoV-2 Main ProteaseChemistry Published on 2021-01-132022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome Against Amino acid Analysis approach binding caused Chinese Compound conformational changes coronavirus COVID-19 Cys145 database docking ensemble sampling enzymatic activity enzyme experimental validation explained functional Gly143 Health His41 Human inhibiting viral replication inhibitor involved M pro MD simulation MD simulations mechanism Medicine molecular molecular dynamics natural products outbreak pandemic Potential protease protein stability provide raised residue SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease screened Screening Simulation TCM Traditional Treatment [DOI] 10.3389/fchem.2020.595273 PMC 바로가기 [Article Type] Chemistry