The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern경구 프로테아제 억제제(PF-07321332)는 우려되는 SARS-CoV-2 변종 감염으로부터 시리아 햄스터를 보호합니다Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] 3CLpro Air-liquid interface Alpha Alpha variant animals Anti-viral Antiviral Antiviral agents B.1.351 B.1.617.2 Beta clinical development clinical trials dosed epithelial cell epithelial cells Evidence evidence of golden hamster golden hamsters hamster in vitro activity Infection infection with SARS-CoV-2 inhibitor intranasal MPro PF-07321332 Pfizer prevented primary human airway Primary human airway epithelial cells protease Protease inhibitor PROTECT reduced Replication SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selective Syrian Golden hamsters target Transmission Treatment variant variants of concern Viral viral replication [DOI] 10.1038/s41467-022-28354-0 PMC 바로가기 [Article Type] Article
The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial CellsArticle Published on 2022-02-112022-10-31 Journal: Cells [Category] Coronavirus, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM17 Apical apical surface association Bacterial Caco-2 CD9 Cell—Cell junctions co-immunoprecipitation coronavirus cultured cell endocytic epithelial epithelial cell epithelial cells epithelium experiments expressed expression identify immunofluorescence microscopy intestinal junction kidney Localized mammary observation promote Protein protein complex Proteins receptor ACE2 target tight junction tissue tissues toxins transmembrane transmembrane protein upregulated virus [DOI] 10.3390/cells11040627 PMC 바로가기 [Article Type] Article
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection차등 인터페론-α 아형 유도 면역 시그니처는 SARS-CoV-2 감염 억제와 관련이 있습니다420 Published on 2022-02-072022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundance activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 additive effects Analysis analyzed Antiviral antiviral activity antiviral drug antiviral host response antiviral host responses antiviral response antiviral responses autoantibody Cell culture cellular Clinical treatment coronavirus Course defined disease downstream early administration Effect effector effector molecule epithelial cell epithelial cells Express functional hAEC help Host Human identify IFN-alpha IFN-I IFN-I signaling IFNs IFNα immune immune response immune responses immune signature Immune-mediated Immunity Immunotherapy Inborn error Inborn errors interferon Interferon-α interferons involved knowledge life-threatening negative regulation Pathologies Pathways pleiotropic primary human airway Primary human airway epithelial cells Prophylaxis Protective proteomic Remdesivir respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus signaling cascade Significance subtype Subtypes Support Therapeutic approach therapeutic potential transcriptional transcriptomic analysis Treatment Type type I IFNs type I interferons Viral Viral diseases viral infections virus viruses [DOI] 10.1073/pnas.2111600119 PMC 바로가기 [Article Type] 420
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cellsResearch Article Published on 2022-02-022022-10-30 Journal: Life Science Alliance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Analysis both viruses carried Cell cellular change changed changes in contribute Coronavirus infection COVID-19 patients disseminate distal driving Effect epithelial cell host cell host cell response human donor infected with SARS-CoV-2 Infection innate immune activation kidney Kidney injury MERS-CoV MERS-CoV infection mitochondrial modulation molecular mechanism Mortality pathology pathway Prevent protein quality control proteome proteomics proximal Quantitative renal renal epithelial cell SARS-CoV-2 SARS-COV-2 infection shared pathway tubular cell viral replication virus [DOI] 10.26508/lsa.202201371 PMC 바로가기 [Article Type] Research Article
HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV-2 Trapping and Antioxidant Therapy동시 SARS-CoV-2 트래핑 및 항산화 요법을 위한 HACE2-엑소좀 기반 나노 미끼Article Published on 2022-02-022022-09-11 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antioxidant Antiviral approach attenuate binding caused Cell cells concurrent Corona coronavirus COVID-19 COVID-19 pandemic cytokine release Cytokine release syndrome Cytokines death effective epithelial cell epithelial cells Exocytosis Exosome expression hACE2 Health Immune cell infiltration Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines kidney Kidney failure microenvironment nano-bait organ injury oxidative oxidative stress pandemic Pneumonia Polydopamine Protein binding resulting robust S protein Safe SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly Trapping Treatment Virus Disease [DOI] 10.1021/acsami.1c19541 PMC 바로가기 [Article Type] Article
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway culturesResearch Article Published on 2022-02-022022-10-30 Journal: Life Science Alliance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome administration air–liquid interface airway angiotensin-converting enzyme-2 apical surface binding Bioavailability blockade blocked Camostat mesylate Cell circulation cleavage clinical trial compounds coronavirus COVID-19 Culture cultures demonstrated develop effective enzalutamide epithelial cell evaluated experiment had no human airway Infection Local metabolised Prevent primary human airway Prophylaxis receptor restrict Safe SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection serine protease serine protease inhibitor Spike protein targeting therapeutic therapeutic strategy TMPRSS2 TMPRSS2 inhibitor topical transmembrane serine protease Treatment Viral transmission [DOI] 10.26508/lsa.202101116 PMC 바로가기 [Article Type] Research Article
All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling PathwayImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1 [DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology
Pharmacokinetic‐based failure of a detergent virucidal for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) nasal infections: A preclinical study and randomized controlled trialControlled Trial Published on 2022-01-312023-06-18 Journal: International forum of allergy & rhinology [Category] MERS, SARS, [키워드] epithelial cell irrigations Saline SARS‐CoV‐2 surfactants topical therapy for chronic rhinosinusitis virus [DOI] 10.1002/alr.22975 PMC 바로가기 [Article Type] Controlled Trial
The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 TreatmentReview Published on 2022-01-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] clinical development cofactor coronavirus COVID-19 epithelial cell expression gastrointestinal tract glycoprotein Influenza inhibiting other organs other respiratory virus physiological Prostate protease Protease inhibitor respiratory viruses SARS-CoV-2 SARS-CoV-2 entry substrate target TMPRSS2 TMPRSS2 inhibitor transmembrane Treatment viral infection [DOI] 10.3390/ijms23031351 PMC 바로가기 [Article Type] Review
What triggers inflammation in COVID-19?Insight Published on 2022-01-202022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] COVID-19 Cytokine storm epithelial cell Inflammation Macrophage pro-inflammatory molecules SARS-CoV-2 Spike protein TLR2 Trigger viruses [DOI] 10.7554/eLife.76231 PMC 바로가기 [Article Type] Insight