Ex vivo
[용어속성] Term
A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
Clinical Trial
[키워드] alveolar damage
Analysis
ARDS
attenuate
Bacterial
caused
Combination
contribute
COVID-19
Dexamethasone
Diffuse alveolar damage
disease
distress
dominant
driver
dysregulated
escaped
Evidence
Ex vivo
function
functional
immune activation
Immune-mediated
immunology
Immunotherapy
Infectious disease
Innate immunity
intrinsically
life-threatening
Local
Lung injury
neutrophil
neutrophil activation
Neutrophil extracellular traps
neutrophil response
Neutrophils
pandemic
parenchymal
Pathogenesis
patients with COVID-19
Pneumonia
priming
question
Respiratory failure
reveal
SARS-COV-2 infection
severe COVID-19
single-cell
syndrome
therapy
unique
Vascular
[DOI] 10.1172/jci.insight.152291 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1172/jci.insight.152291 PMC 바로가기 [Article Type] Clinical Trial
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination
Immunology
[키워드] Activation
adaptive
adenoviral vector vaccine
adenovirus vector vaccine
age
antibody
Antibody titer
association
AZD1222
B cell
CD14
CD27
CD3
CD56
CD86
Cell
ChAdOx1 nCoV-19
collected
connection
correlated
CpG
Critical
cytokine production
double-negative B cell
enrolled
Ex vivo
expression
first vaccination
FIVE
flow cytometry
granzyme B
IFN-γ
IGD
imiquimod
Immune cell
immune response
Immunity
immunosenescence
information
Innate
innate immune
innate immune activation
innate immune response
Innate immunity
LPS
marker
memory B cell
monocyte
naïve
naïve B cell
natural killer
neutralization
Neutralizing antibodies
neutralizing antibody
NK cell
Older
pattern recognition receptor
Production
response
responses
Result
SARS-CoV-2 vaccines
SARS-CoV2
serum
significantly higher
stimulated
subject
sVNT
TLR
TLR agonist
TLR stimulation
TLR9
Toll-like receptor
vaccination
vaccinee
Virus neutralization
were measured
[DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm Syndrome
Article
[키워드] accompanied
Activation
approach
Blood
caused
CD107a
CD8 T cell
Cell
clinical feature
Coronavirus disease 2019
COVID-19
cytokine levels
Cytokine storm
Cytokine storm syndrome
cytolysis
cytotoxicity
death
degranulation
disease
dominant-negative
elevated
erythroleukemia
etiologies
Ex vivo
expression
feature
gene mutations
genetic defect
genetic evaluation
genetic mutations
genetics
hemophagocytic lymphohistiocytosis
heterozygous
HLH
homozygous
hyperinflammation
hypomorphic
Hypothesis
immune response
immune system
implicated
implication
in vitro
infancy
Laboratory
lentiviral
macrophage activation syndrome
Missense mutation
monoallelic
mutant
Mutation
natural killer
natural killer cell
NK cell
NK cell function
resulting
secondary
Severe case
severe COVID-19
sHLH
significantly
stimulated
storm
STXBP2
syndrome
system failure
target cell
transduced
triggered
viral infection
were measured
while
wild-type
[DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease
Article
[키워드] activated
administration
Affect
airway
airway epithelial cell
airway epithelium
anthelminthic
applied
Asthma
asthmatic
Calu-3
cells
chronic obstructive
circumvent
CLCA1
clearance
comparable
Compound
COVID-19
delivery
disease
drugs
Effect
effective
encapsulation
Ex vivo
examined
explained
fibrosis
glycol
human airway epithelial
hydrospheres
in vitro
in vivo
Inflammatory
inflammatory airway disease
Influenza
inhibit
inhibited
inhibitory effect
intratracheal instillation
Local
mice
Nanospheres
niclosamide
pro-inflammatory
problems
proinflammatory
pulmonary disease
repurposing
respiratory syncytial virus
SARS-CoV-2
secretion
Side effects
TMEM16A
TMEM16F
Trachea
tracheas
Treatment
viral respiratory infections
were assessed
while
[DOI] 10.3390/ijms23031085 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms23031085 PMC 바로가기 [Article Type] Article
Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19
Article
[키워드] absence
accumulated
anti-RBD
anti-receptor-binding domain
antibody
biodistribution study
can be used
candidate
Cell
Characteristics
chicken
coronavirus disease
COVID-19
effective
Egg
evaluate
Ex vivo
exceeded
feasibility
Health
IgY anti-RBD spike SARS-CoV-2
immunization
in vitro
in vivo
International
intranasal
mice
Mortality
neutralize
other organs
Passive
passive immunization
Preclinical
preclinical data
preclinical evaluation
preclinical studies
Prophylactic
radiolabeled
radiolabeled IgY
RBD
resulting
safety profile
SARS-CoV-2
spike
the SARS-CoV-2
Treatment
virus
yolk
[DOI] 10.3390/vaccines10010128 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/vaccines10010128 PMC 바로가기 [Article Type] Article
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread
siRNA로 게놈 SARS-CoV-2 RNA를 표적화하면 바이러스 복제 및 확산을 효율적으로 억제할 수 있습니다.
AcademicSubjects/SCI00010
[키워드] 3′ end
active against
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus-2
antiviral efficacy
approach
cell entry
conserved
conserved region
Coronavirus-2
COVID-19
discontinuous transcription
effective
Ex vivo
Frame
genomic
genomic RNA
gRNA
human lung
inhibited
Open reading frame
open reading frame 1
ORF1
Prevent
Prophylactic
Region
replicate
Replication
respiratory
RNA
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 RNA
sequence
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
sgRNA
sgRNAs
siRNA
siRNAs
Spread
target
targeting
therapy
transcript
Transcription
transcripts
translational
unique
Verifying
Viral
viral replication
Viral RNA
viral transcript
viral transcripts
virus-induced cell death
[DOI] 10.1093/nar/gkab1248 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
[DOI] 10.1093/nar/gkab1248 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
Research Article
[키워드] abrogated
Anti-inflammatory therapy
anti-inflammatory treatment
autocrine
Bacterial
Bacterial infection
bacterial superinfection
bacterial superinfections
caused
CD11b
CD163
CD66b
CD86
Cell
cellular
characterized
classical
Clusters
complicate
Course
COVID-19
COVID-19 patient
COVID-19 patients
Critically ill
CRP
CXCR1
CXCR2
CXCR4
cytokine
cytokine levels
cytokine signaling
Dexamethasone
disease severity
driven by
dysregulated
dysregulation
elevated
Ex vivo
exacerbate
exhibited
expression
function
functional
HLA-DR
host response
host-response
hypercytokinemia
Hyperinflammatory
ICU
IFN-γ
IL-4
IL-6 level
Immune cell
immune cells
immune response
IMPROVE
increased mortality
induce
Inflammatory marker
inflammatory mediator
Inflammatory mediators
innate immune function
Innate immunity
low expression
monocyte
Monocytes
MPO
myeloid cell
NET
neutrophil
paracrine
paralysis
patients
phenotype
phenotypic
plasma
provide
receiving
reduced
reduction
reduction in
reflected
response
ROS production
SARS-CoV-2
SARS-CoV-2 pathogenesis
subsequent
suppressed
surface receptor
Symptom
synergistic
systemic inflammation
the disease
TNF-α
treated
utility
[DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Effect of mRNA Delivery Modality and Formulation on Cutaneous mRNA Distribution and Downstream eGFP Expression
Article
[키워드] biodistribution
Cell
Cutaneous
delivery
distribution
Effect
Efficiency
eGFP
Ex vivo
expressing
expression
facilitate
fluorescent
Formulation
fractional laser ablation
immunohistochemistry
injection
intradermal injection
investigated
Jet injection
knowledge
microneedle injection
Microscopy
modality
mRNA
mRNA delivery
mRNA-based
Protein
protein expression
responsible
semi-quantitative
therapeutic
transcribed
Visualization
was used
[DOI] 10.3390/pharmaceutics14010151 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/pharmaceutics14010151 PMC 바로가기 [Article Type] Article
C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19
C5a 및 C5aR1은 aHUS에서 COVID-19에 이르는 임상 기관에서 미세혈관 혈소판 응집의 주요 동인입니다
Article
[키워드] Activation
acute respiratory syndrome
added
aggregation
Alternative pathway
antithrombogenic
Atypical
Bacterial infection
Bacterial infections
binding
blockade
C5a
C5aR1
C5b-9
caused
CCX168
Cell
chronic inflammatory diseases
clinical entity
clinical implications
Comorbidities
Comorbidity
complement
complement system
coronavirus
COVID-19
Critical
demonstrated
develop
driver
dysfunction
dysregulation
Effect
endothelial
endothelial cells
Endothelial dysfunction
Endothelium
Ex vivo
Exocytosis
Genetic
hemolytic uremic syndrome
highlight
human serum
Hyperactivation
Infection
Inflammatory diseases
Microvascular thrombosis
normal human serum
P-selectin
pathogenic mechanisms
Patient
patients treated
Platelet
platelet adhesion
prothrombotic
RalA
rare disease
Registered
selectin
serum
severe acute respiratory syndrome Coronavirus
severe COVID-19
severely ill patients
suffered
thrombosis
Thrombus
thrombus formation
translate
Trial
triggered
uremic syndrome
viral infections
von Willebrand factor
[DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article
[DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article