Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19Research Article Published on 2021-11-152022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute lung injury administration alveolar-capillary barrier caused Cell cell death cells cellular contribute COVID-19 cytokine disease distress dose dysfunction effective Evidence extracellular vesicle Health immune modulation impairing Inflammation Injury lung Lung inflammation mesenchymal stem cell Particle Pathogenesis pathology pro-inflammatory pro-inflammatory cytokine pulmonary epithelial cell RBD Receptor binding domain reduce reduced response SARS-CoV-2 secretion Signaling surface protein the SARS-CoV-2 therapeutic potential translation Treatment [DOI] 10.1371/journal.pone.0259732 PMC 바로가기 [Article Type] Research Article
Blood Nanoparticles – Influence on Extracellular Vesicle Isolation and CharacterizationPharmacology Published on 2021-11-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulate Affect aggregates Analysis Autoimmune Biomarker Biomarkers Blood blood nanoparticles blood plasma Cancer cardiovascular diseases Cell cell types Characteristics characterization characterization methods Concentration contaminant Contaminants Degradation disease downstream downstream analysis EVs extracellular vesicle Extracellular vesicles help Impact IMPROVE include influence Interpretation isolate Isolation isolation methods lipoprotein miRNAs molecular molecular component nanoparticle neurodegenerative organ outcome Particle physiological Protein Proteins released reliability reproducibility secreted tissues unique virus [DOI] 10.3389/fphar.2021.773844 PMC 바로가기 [Article Type] Pharmacology
COVID-19 and biomarkers of thrombosis: focus on von Willebrand factor and extracellular vesiclesCOVID-19 및 혈전증 바이오마커: 폰 빌레브란트 인자 및 세포외 소포체에 초점Review Published on 2021-11-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 바이오마커, [키워드] acute phase Affect approach Biomarker Biomarkers cause caused COVID-19 diagnostic duration of illness extracellular vesicle Extracellular vesicles Factor Health Infection life management morbidity and mortality organ organ system pandemic pathophysiology Quality of life responsible SARS-CoV-2 virus the SARS-CoV-2 virus thrombosis von Willebrand factor while [DOI] 10.1007/s11239-021-02544-x PMC 바로가기 [Article Type] Review
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactionsArticle Published on 2021-10-192022-10-29 Journal: Nature Communications [Category] COVID-19, [키워드] aggregate aggregates association Cell cells cellular Contact contribute determinant disease dissemination ENhance exchange extracellular space extracellular vesicle glycoprotein Interaction interactions intercellular Mechanisms of disease neurodegeneration neurodegenerative pathogenic pathway Protein Protein misfolding Proteins raise released SARS-CoV-2 spike secreted transfer Transmission vesicular stomatitis virus viral glycoprotein viral infection viral ligand [DOI] 10.1038/s41467-021-25855-2 PMC 바로가기 [Article Type] Article
Role of Extracellular Vesicles in Cell Death and Inflammation세포 사멸 및 염증에서 세포외 소포의 역할Review Published on 2021-10-052022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] apoptotic bodies apoptotic extracellular vesicles Cell cell death conditions death effector EVs Exosomes extracellular vesicle Extracellular vesicles focus immune immune response immune responses Infection Inflammation Intercellular communication leads Lung inflammation lung inflammatory disorders mediators Microvesicles modulating pathology pathophysiological role SARS-CoV-2 Sepsis tissue damage upregulation Vesicle [DOI] 10.3390/cells10102663 PMC 바로가기 [Article Type] Review
Mesenchymal Stem Cells in the Treatment of COVID-19, a Promising FutureReview Published on 2021-09-292022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acute respiratory distress Affect affected alterations ambient ARDS cardiac function cause Cell therapy cell types clinical trial COVID-19 COVID-19 patient culture media develop Diseases embryonic extracellular vesicle Factor Future genetic manipulation in vivo Inflammation Inflammatory response Intravenous injection lung Manifestations mesenchymal stem cell Mesenchymal stem cells MSC MSCs paracrine pluripotent stem cells renal Safe secretion Secretome STEM stem cell supernatant syndrome tested the disease therapeutic these cell Thromboembolism tissue tissue regeneration Treatment [DOI] 10.3390/cells10102588 PMC 바로가기 [Article Type] Review
Biology and Pathogenesis of SARS-CoV-2: Understandings for Therapeutic Developments against COVID-19Review Published on 2021-09-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alphacoronavirus Analysis animal models antiviral drugs antivirals Biology caused Characteristics Complete Coronavirus disease 2019 Coronaviruses COVID-19 development EVs extracellular vesicle FIVE Genetic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs host-pathogen interaction host-virus interaction Human immune-evasion knowledge MERS-CoV Nidovirale Pathogenesis pathophysiology positive Research RNA virus SARS-CoV SARS-CoV-2 single-stranded the Coronaviridae the disease understanding Vaccine Vaccines virus [DOI] 10.3390/pathogens10091218 PMC 바로가기 [Article Type] Review
Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with RemdesivirArticle Published on 2021-09-162022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] activity anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug biogenesis calpeptin calu-3 cells clinical study Combination coronavirus disease COVID-19 cysteine cytotoxicity demonstrated dose-dependent inhibition drug Effect EVs exhibited expression extracellular vesicle Extracellular vesicles half-maximal inhibitory concentration Health IC50 Impact infected cell inhibited inhibitor inhibitors monotherapy pandemic pathway proteinase release mechanism Remdesivir SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral replication screened Screening significantly small molecule inhibitor therapeutic efficacy validation Vero E6 cell VERO-E6 virion virus [DOI] 10.3390/biomedicines9091230 PMC 바로가기 [Article Type] Article
Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocolCovid-19에 대한 치료 중재로서의 중간 엽 기질 세포 : 살아있는 체계적인 검토 및 메타 분석 프로토콜Protocol Published on 2021-09-152022-08-31 Journal: Systematic Reviews [Category] COVID-19, meta-analysis, SARS, [키워드] activated acute respiratory distress syndrome adverse event adverse events ARDS benefit Case series characterization Clinical outcome clinical study Community concerning conditioned media Controlled controlled trials Coronavirus disease 2019 COVID-19 CRD data extraction database determine Efficacy Evidence Exosomes extracellular vesicle Extracellular vesicles global pandemic Health Health policy immune response immune responses immunomodulatory information Isolation Laboratory lack life-threatening Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells meta-analyses Meta-analysis Microvesicles Mild MSC MSCs non-randomized outcomes pandemic Patient patient population performed Pneumonia populations protocol random-effect random-effects Random-effects meta-analysis Randomized real time SARS-CoV-2 SARS-COV-2 infection secreted Secretome Sepsis severe acute respiratory syndrome coronavirus 2 stromal cells subsequent supplementary material systematic literature search systematic review therapeutic intervention tissue repair treat trials [DOI] 10.1186/s13643-021-01803-5 PMC 바로가기 [Article Type] Protocol
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2SARS-CoV-2에 대한 중간엽 줄기세포의 세포외 소포에서 Micrornas의 잠재적 치료 효과Article Published on 2021-09-122022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter anti-SARS-CoV-2 anti-viral response binding cellular physiology complementary components conserved coronavirus COVID-19 Cytokine storm Cytopathic effect cytopathic effects differentiation Effect EVs expressed expression extracellular vesicle Extracellular vesicles FIVE human gene human genes immune response immune responses infected cell infected cells Infection inhibiting membrane-bound mesenchymal stem cell micro-RNA microenvironment miR-181a-5p miR-23a-3p miRNA miRNAs mRNAs mutated myriad nucleic acids peptides Potential Proinflammatory response proliferation Proteins Region regulate released rescue respiratory RNAs SARS-CoV-2 SARS-CoV-2 virus sequence severe acute respiratory syndrome Coronavirus STEM suppression tested therapeutic agent therapeutic agents UTR variant variety Vesicle vesicles Viral viral gene viral genome viral infection viral replication [DOI] 10.3390/cells10092393 PMC 바로가기 [Article Type] Article