A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial파키스탄에서 경증에서 중등도의 COVID-19 환자에 대한 요오드 복합체의 효과를 평가하기 위한 4중 맹검 위약 대조 무작위 시험(I-COVID-PK): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 30-Day mortality Admission age alleviation alleviation of symptom approved Arm ARMS baseline blinded Blinding calculated Care care providers Chest chest scan Chronic illness clinic clinical Clinical improvement Clinical management co-morbidities co-morbidity comparator complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patient COVID-19 adult patients Disinfection dissemination doctor Effectiveness Efficacy element enrolled evaluate excluded four group four groups Gender groups HRCT Infection information initial initial symptom initial symptoms Intention investigator investigators Iodine IRB lung involvement management guidelines Mild mild to moderate mild to moderate disease Moderate COVID-19 moderate disease morbidities National Health Service National Health Services non-pregnant females number objective outcome Pakistan participant Participants Patient patients PCR Placebo placebo-controlled Polymer positive Primary outcomes protocol radiological radiological improvement randomised randomised controlled trial Randomised trial randomization Randomized receiving recruited recruitment Registered remained reported resolved RT-PCR Sample size SARS-CoV-2 RT-PCR secondary outcome severity severity of symptom shown Standard standard care status Study protocol supplementary material Symptom symptomatic syrup the patient time Trial Version Viral viral clearance website [DOI] 10.1186/s13063-021-05081-3 PMC 바로가기 [Article Type] Letter
Learning in peer teaching of patient relations and communication skills at the “Anamnesegruppen” Munich – proof-of-concept and lessons learnedArticle Published on 2021-01-282022-11-01 Journal: GMS Journal for Medical Education [Category] Coronavirus, [키워드] adaptation addition anamnesis groups Balint conducted confidentiality Corona Course COVID-19 digital teaching e-learning eight element evaluated feasibility Final four group group groups independent learning medical history Munich no significant difference not differ organized pandemic participant Patient patient interview peer-teaching positive preserved question recruited relationship medicine Research Stress student student teaching switching the patient [DOI] 10.3205/zma001400 PMC 바로가기 [Article Type] Article
Clinical characteristics of outpatients and inpatients with COVID-19 in Bushehr: a report from the south of IranShort Communication Published on 2021-01-252022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] analyzed aspartate Blood Bushehr Characteristics clinical Clinical features Computed tomography COVID-19 COVID-19 patient creatinine CRP elderly elderly patients enrolled erythrocyte sedimentation rate feature four group ground-glass opacity Hospitalization incidence increased risk Inpatient Inpatients Iran Laboratory laboratory markers lactate dehydrogenase Level material outpatients outpatients and inpatient Patient patients progression renal SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significant difference significantly higher underlying condition Urine with COVID-19 [DOI] 10.2217/fvl-2020-0231 PMC 바로가기 [Article Type] Short Communication
Socioeconomic disparity and the risk of contracting COVID-19 in South Korea: an NHIS-COVID-19 database cohort studyResearch Article Published on 2021-01-152022-10-28 Journal: BMC Public Health [Category] COVID-19, [키워드] affected age Analysis analyzed association Cohort cohort study collected control groups coronavirus disease COVID-19 COVID-19 patient database diagnosed Final four group group higher risk highest income individual infections Korean Lower lower risk lowest multivariable logistic regression no significant differences older population prevention of COVID-19 Result risk social class South South Korea statistically Strategy study participant supplementary material was used [DOI] 10.1186/s12889-021-10207-y PMC 바로가기 [Article Type] Research Article
COVID-19 in Russia: Clinical and Immunological Features of the First-Wave PatientsResearch Article Published on 2021-01-012022-10-28 Journal: Acta Naturae [Category] COVID-19, [키워드] Academy affected Analysis antibody Antigen antigens caused clinical Comorbidity comparable computed tomographic conformational coronavirus disease Correlation analysis country COVID-19 criterion deaths demonstrated diabetes diagnostic died distribution E. coli effort ELISA ELISA kit epitope Epitopes eukaryotic evaluated examined faster First wave FIVE four group functional global pandemic Ground-glass opacities group Health authority hypertension IgA IgA antibody IgG subclasse IgM immune response Immunoglobulin immunoglobulin A immunological IMPROVE inclusion criteria involved linear N-protein NTD occurrence rate on mechanical ventilation outbreak pandemic Patient positive PCR test produced RBD recombinant Region representing resource Russia S-protein SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2-specific antibody subclasses Science sensitivity sera Seroconversion seroconversion rate serological serological analysis of patients with COVID-19 seropositive severity of COVID-19 significantly specific antibodies syndrome the disease the patient the RBD fragment Viral pneumonia was performed was used [DOI] 10.32607/actanaturae.11374 PMC 바로가기 [Article Type] Research Article
A retrospective comparison of drugs against COVID-19Comparative Study Published on 2020-12-142022-10-04 Journal: Virus research [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제, [키워드] analyzed Antibody detection Arbidol combination therapy coronavirus disease 19 Corticosteroid Corticosteroids COVID-19 drug Drug repurposing Effect exhibited four group General population groups Hospital stay Hydroxychloroquine hydroxychloroquine group IgG level IgM indicated Lopinavir/ritonavir management monotherapy oseltamivir outcome pandemic patients treated reduced retrospective SARS-COV-2 infection serological significantly significantly higher significantly shorter threat [DOI] 10.1016/j.virusres.2020.198262 PMC 바로가기 [Article Type] Comparative Study
Detection of severe acute respiratory syndrome coronavirus 2 in nasopharynx according to clinical phenotype of affected patients환자의 임상적 표현형에 따른 비인두의 중증급성호흡기증후군 코로나바이러스 2 검출Article Published on 2020-12-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 치료기술, [키워드] activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted affected analysed asymptomatic individual Asymptomatic individuals asymptomatic patient asymptomatic patients characterized clinical phenotype conducted consecutive negative tests Contact tracing coronavirus coronavirus disease Coronavirus disease 2019 Critically ill critically ill patients detection disease disease control disease severity Duration emergency department first positive four group four groups Hospitalized in viral individual individuals Infectious disease Infectivity intensive care intensive care unit intensive care units interquartile range investigated Italian Italy measure median Mild disease multivariate analyses Multivariate analysis nasopharyngeal Nasopharyngeal swab nasopharynx negativity no difference Patient PCR tests positive individual positive individuals positive test result real-time RT-PCR real-time RT-PCR test respiratory RT-PCR test RT-PCR tests SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen standard error symptomatic patient Symptomatic patients symptomatic status test result tested university university hospital upper respiratory upper respiratory tract Viral viral shedding Virology with mild disease [DOI] 10.1016/j.cmi.2020.08.041 PMC 바로가기 [Article Type] Article
Specific dynamic variations in the peripheral blood lymphocyte subsets in COVID-19 and severe influenza A patients: a retrospective observational studyCOVID-19 및 중증 인플루엔자 A 환자의 말초 혈액 림프구 하위 집합의 특정 동적 변화: 후향적 관찰 연구Observational Study Published on 2020-12-012022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] (T cells Affect alteration Blood donors CD4 CD8 change Clinical significance Comorbidities contribute Coronavirus disease-19 (COVID-19) COVID-19 determine different time point different time points Disease progression early infection examined Flow cytometric analysis four group four groups healthy blood donors healthy controls healthy donor healthy donors hospital immune mechanism increased mortality Influenza influenza A leukocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Patient patients’ data performed Peripheral blood Prognosis Result retrospective severe COVID-19 Severe influenza A significantly lower Specific stages supplementary material T cell T cells T cells subsets the patient turn Variation [DOI] 10.1186/s12879-020-05637-9 PMC 바로가기 [Article Type] Observational Study
Temporal lung changes on thin-section CT in patients with COVID-19 pneumoniaArticle Published on 2020-11-122022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] Admission average change Characteristics Chest CT China consolidation COVID-19 patient COVID-19 patients discharge examined Follow-up four group Frequency GGO group highest hospital illness onset Infectious diseases Isolation lesion lowest lung lung abnormality median age occurred Patient patients patients with COVID-19 percentage Pneumonia prevalent ranged reduced Temporal Total viral infection [DOI] 10.1038/s41598-020-76776-x PMC 바로가기 [Article Type] Article
Hyperimmune anti-COVID-19 IVIG (C-IVIG) Therapy for Passive Immunization of Severe and Critically Ill COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-022022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 28-day mortality accompany acute lung injury adverse event airway All participant allergic anti-COVID19 IVIG Anti-viral Antibiotics assigned assisted ventilation autoimmune disorder blinded Blood oxygen saturation blood pressure C-IVIG Care Clinical efficacy Comparator group convalescent plasma COVID-19 COVID19 criteria Critically ill Critically ill patient CRP current disorder dosage Dyspnea excluded Follow-up four group group hemodynamic hemolytic anemia hospital hospital discharge Hospital stay hypersensitivity ICU IgA deficiency Ill immunization Immunoglobulin include infected individual Inflammation information inotropic agent Intervention intervention arm Isolation Karachi kidney Kidney failure lung infiltrate maintain Manifestations medication Meningitis MONITOR multiple organ dysfunction nasopharyngeal neutrophil lymphocyte ratio number objective observé oropharyngeal swabs outcome PaO parallel-group participant Passive passive immunization Patient patients positive SARS-CoV-2 PCR pregnant females Primary outcome protocol randomised randomised controlled randomised controlled trial randomization receive recruited Registered reported Respiratory failure respiratory rate Sample size sealed Septic shock shifting single dose standard care status Steroids Study protocol Support symptoms of COVID-19 therapy thromboembolic Total Treatment Trial university website were excluded with COVID-19 [DOI] 10.1186/s13063-020-04839-5 PMC 바로가기 [Article Type] Letter