The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration ResearchK18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점Review Published on 2022-06-282022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development [DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review
Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infectionMVA 기반 백신의 비강내 접종은 IgA를 유도하고 SARS-CoV-2 감염으로부터 hACE2 마우스의 호흡기를 보호합니다Article Published on 2022-06-142022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome administration Antigen Beta Blood CD3 CD8 coronavirus coronavirus 2 coronavirus vaccine COVID-19 COVID-19 pandemic current effective expressing firefly luciferase hACE2 IFN-γ IgA IgG immune responses Immunity immunized Immunoglobulin immunoglobulin A Immunoglobulin G induce Infection Infectious virus intramuscular intramuscular vaccination intramuscularly intranasal intranasally K18-hACE2 less luciferase Luminescence lung Lungs mice modified vaccinia virus morbidity mucosal mucosal immunity nasal turbinate nasal turbinates neutralized Neutralizing antibodies neutralizing antibody omicron Prevent prevented priming PROTECT protective immune response pseudovirus pseudoviruses raise remained respiratory respiratory immunity respiratory tract S protein S proteins SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity T cells the S protein Transmission upper respiratory tract vaccination Vaccine vaccinia virus variants Viral while Wuhan [DOI] 10.1073/pnas.2202069119 PMC 바로가기 [Article Type] Article
Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccinationhACE2 마우스에서 SARS-CoV-2와 Streptococcus pneumoniae 간의 치명적인 시너지 효과와 예방 접종의 보호 효능Article Published on 2022-06-082022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 폐렴구균 감염증, [키워드] alveolar approach Bacteria Bacterial Bacterial infections Combined Complication COVID-19 death dose effective Efficacy GM-CSF hACE2 IFNs immunology incidence Increased Infection Infectious disease Influenza lethal lung Lung inflammation Macrophage mice Molecular pathology mouse Mouse models murine occurred pathogen pathology pneumococcal infection pneumococci Protective reduced respiratory infection SARS-CoV-2 secondary Streptococcus pneumoniae subsequent survival synergistic synergy therapeutic targeting Treatment vaccination viral respiratory infections [DOI] 10.1172/jci.insight.159422 PMC 바로가기 [Article Type] Article
Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine범사르베코바이러스 수지상세포 표적화 백신의 설계, 면역원성 및 효능Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Antigen antigens antiviral efficacy B-cell epitope B-cell epitopes BNT162b2 CD40 conserved Coronaviruses COVID-19 cross-neutralizing antibodies cross-neutralizing antibody cross-reactive demonstrated dendritic cells Efficacy elicited ENhance Epitopes framework functional hACE2 homologous immunization immunogenic immunogenicity in vitro initiative K18-hACE2 transgenic mice Medicine MERS mice mRNA BNT162b2 vaccine Mutation Neutralizing antibodies nucleocapsid potency Pre-clinical model protein subunit vaccine recall Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S spike Subunit vaccine supported surface receptor survival T-cell Response T-cell responses Vaccine variants of concern Viral viral control VoC VOCs [DOI] 10.1016/j.ebiom.2022.104062 PMC 바로가기 [Article Type] Article
Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing Mice인간 ACE2-발현 마우스에서 우려되는 SARS-CoV-2 변이체의 차별적 병인 발생Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing mice acute respiratory syndrome acute respiratory syndrome coronavirus Alpha B.1 B.1 lineage B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Brain caused chemokine chemokines circulating circulating variant Clinical sign concern contagious coronavirus COVID-19 cytokine Cytokines death evaluated exhibited hACE2 Human Infection Inflammation inoculated intranasally K18-hACE2 K18-hACE2 mice less lineages lung Lungs mice mouse-adapted SARS-CoV-2 omicron pandemic Pathogenesis pathogenesis of SARS-CoV-2 question Replication resulting SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity significantly significantly higher significantly lower significantly more survival rate the disease Transcription variant variants of concern virus virus titer [DOI] 10.3390/v14061139 PMC 바로가기 [Article Type] Article
Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice치명적인 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 ZF2001의 효과적인 보호Article Published on 2022-05-202022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, [키워드] aluminum approval China Delta delta variant Efficacy Epidemics hACE2 improvement K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice Lung histopathology mechanism neutralizing antibody omicron Prevent protection Protective protective effect protein subunit vaccine reduced required Research research and development SARS-CoV-2 SARS-CoV-2 Delta variant severe cases severe pneumonia Subunit vaccine survival rates the SARS-CoV-2 Vaccine Vaccine design variant virus was used ZF2001 ZF2001. [DOI] 10.1186/s12985-022-01818-x PMC 바로가기 [Article Type] Article
Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage저온 혈장을 사용한 SARS-CoV-2 유사 코로나바이러스, 유사형 SARS-CoV-2 및 기타 코로나바이러스의 효율적인 소독으로 스파이크 단백질 손상 유도Article Published on 2022-05-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 변종, [키워드] angiotensin atmospheric binding Cold Cold pressure plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dominant efficient Epidemic Evidence evidence of hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 inactivation induce other coronavirus other coronaviruses PEDV Peroxynitrite anion plasma provide pseudotyped SARS-CoV-2 Pseudotyped variants public health emergency pulse raised RBD reactive Receptor binding domain Recognition responsible SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 variant SARS-CoV-2 variants short-lived Short-lived reactive species. Spike protein strain transmission of SARS-CoV-2 variant Viral transmission [DOI] 10.1016/j.jhazmat.2022.128414 PMC 바로가기 [Article Type] Article
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant InfectionC57BL/6J 마우스는 심각한 SARS-CoV-2 베타 및 감마 변종 감염을 모델링하는 데 적합하지 않습니다.Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Alpha angiotensin Angiotensin converting enzyme-2 ARDS B.1.1.7 B.1.351 B.1.617.2 Beta body weight Body Weight Changes C57BL/6 CCR2 change changes clinical disease deficiency Delta entry of SARS-CoV-2 eosin Evidence evidence of examined expression Gamma H&E H&E staining hACE2 hACE2 receptor hematoxylin histology IHC IHC staining immune immune deficiency Immunocompromised immunocompromised mice immunohistochemistry indicated infect Infection lung Lung pathology mice modeling Mutation P.1 pathologic pathological change pathological changes Probability qPCR RAG2 receptor replicate required SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 shown staining survival These data three group three groups transgenic mice Transmissibility variant variants variants of concern variants of SARS-CoV-2 Viral antigen Viral protein viral titer virulence VoC VOCs weight loss were used [DOI] 10.3390/v14050966 PMC 바로가기 [Article Type] Article
Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice폐 실질 세포를 표적으로 하고 SARS-CoV-2-감수성 마우스를 개발하기 위한 AAV의 비침습적 투여Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 치료법, [키워드] AAV AAV2/8 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus administration Alveolar Type II angiotensin AT1 AT2 can be used Cell cells coronavirus develop enzyme expression gene delivery gene knockout Gene therapy hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 IFNAR immune immune function injected interferon receptor intratracheal administration intratracheal injection lung lung targeting. lung tissue lung tissues Lungs mice multiple lesion multiple lesions Non-invasive nucleocapsid protein parenchymal Protein pulmonary diseases receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling target technique Trachea transduced type I interferon viral titer virus [DOI] 10.1016/j.ymthe.2022.01.010 PMC 바로가기 [Article Type] Article