Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial기준 항체 및 항원 수준에 따른 COVID-19 입원 환자의 중화 단일클론항체에 대한 반응: 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] allergy Analysis analyzed Anti-spike antibodies antibody Antigen bamlanivimab baseline benefit clinical trial collected Combination Controlled COVID-19 death defined detectable discharge elevated end-organ evaluate evidenced favor futility Government greater hazard hazard ratios hospitalized patient hospitalized patients Hypothesis immune IMPROVE independent Infectious diseases Interaction Level limited sample size median median time monoclonal antibody mounted Multicenter trial NAb NAbs nasal neutralizing antibody not differ operation Organ failure outcome participant Patient patients with COVID-19 Placebo placebo group placebo-controlled placebo-controlled trial plasma Randomized receiving Remdesivir required response SARS-CoV-2 nucleocapsid Serious Adverse Events serious infections serostatus small sample size specimen speed subgroup subgroup analysis sustained the median therapy Trial Viral Viral RNA with COVID-19 [DOI] 10.7326/M21-3507 PMC 바로가기 [Article Type] Randomized Controlled Trial
Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in StockholmObservational Study Published on 2022-01-272022-10-04 Journal: European Journal of Epidemiology [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] addressed Admission Atrial fibrillation Characteristics co-morbid condition collider comorbid condition Complete Coverage COVID 19 COVID-19-related death deaths determinant diabete disease severity Epidemiology Factor hazard heart failure high risk High-resolution Hospitalization hypertension ICU ICU admission in-hospital patient increased risk infections Intensive intensive care ischemic heart disease Kidney failure majority Mortality obesity observation period Observed occurred Older overall mortality pandemic Patient Protective question raise risk risk factor Risk factors Scientific community Selection bias study period supplementary material were assessed [DOI] 10.1007/s10654-021-00840-7 PMC 바로가기 [Article Type] Observational Study
Early effectiveness of BNT162b2 Covid-19 vaccine in preventing SARS-CoV-2 infection in healthcare personnel in six Israeli hospitals (CoVEHPI)BNT162b2 코비드-19 백신이 이스라엘 6개 병원(CoVEHPI)의 의료진에서 SARS-CoV-2 감염을 예방하는 초기 효과Article Published on 2022-01-242022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] 95% CI adjusted Alpha Alpha variant BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 mRNA vaccine circulation conducted COVID-19 vaccination COVID-19 vaccine Cox proportional hazards model creating dose Effectiveness Endpoint enrolled Enrollment evaluate event first dose Fisher Fisher's exact test follow-up period hazard hcp healthcare personnel hospital Infection nasal National nine of BNT162b2 participant Participants PCR PCR-confirmed PCR-positive Pfizer predominant primary analysis proportional hazards model Prospective Study provided Questionnaires SARS-COV-2 infection Seroconversion serology specimens study participant Study participants Surveillance Symptom uninfected participant vaccination Vaccine variant [DOI] 10.1016/j.vaccine.2021.11.092 PMC 바로가기 [Article Type] Article
Managing Compound Hazards: Impact of COVID-19 and Cases of Adaptive Governance during the 2020 Kumamoto Flood in JapanArticle Published on 2022-01-212022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] adaptive adaptive governance affected approach complex Compound compound hazards country COVID-19 COVID-19 case COVID-19 pandemic effective effort evacuation flood generate Governance hazard hazards identify Impact increase in Japan Kumamoto Local managing mechanism organization overcome platform preventive measure problem questionnaire risk volunteerism while [DOI] 10.3390/ijerph19031188 PMC 바로가기 [Article Type] Article
A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19중증 COVID-19 환자의 회복기 혈장 치료를 위한 2상 단일 센터 공개 라벨 무작위 대조 시험Clinical Trial Published on 2022-01-192022-09-12 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] 95% confidence interval adverse effect Adverse reaction all-cause mortality ARDS benefit characterized clinical clinical benefit clinical trial clinical trials Controlled trial convalescent plasma Convalescent plasma therapy COVID-19 disease cytokine Cytokines enrolment Evidence FiO2 General Hospital hazard hyper-inflammation immunization immunological inclusion criteria India Infectious disease Infectious diseases Intervention Kolkata log-rank log-rank test Mantel-Haenszel mechanical ventilation Mild Mild ARDS moderate moderate ARDS Mortality neutralizing antibody not affect not significantly different on mechanical ventilation open label outcome Outcomes research p value PaO2 paO2/fiO2 passive immunization Patient patients patients hospitalized PCR Phase 2 plasma plasma therapy prespecified outcomes Primary outcome Primary outcomes proteome randomised randomised controlled trial Randomized Ratio recruited Registered registry reported response to therapy secondary outcome Secondary outcomes severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients single center Standard of care systemic hyper-inflammation the systemic hyper-inflammation therapy treat Treatment treatment arm Trial viral infection Viral RNA was done [DOI] 10.1038/s41467-022-28064-7 PMC 바로가기 [Article Type] Clinical Trial
What are the risk factors of hospital length of stay in the novel coronavirus pneumonia (COVID-19) patients? A survival analysis in southwest ChinaResearch Article Published on 2022-01-142022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% confidence interval Admission age Analysis applied China Clinical characteristics COVID-19 COVID-19 infection COVID-19 patient Critical demographic characteristics Diagnosis Epidemic epidemiological Factors Gender hazard healthcare healthcare worker hospital Hospitalized illness onset interquartile range Kaplan-Meier method laboratory-confirmed Local males median medical resource Medical resources mild symptoms Model Novel coronavirus Older Outbreaks Patient patients Pneumonia regions Reporting resource Result retrospective risk factor strongly related suggested survival System Treatment understanding with COVID-19 [DOI] 10.1371/journal.pone.0261216 PMC 바로가기 [Article Type] Research Article
Hospital outcomes of community-acquired COVID-19 versus influenza: Insights from the Swiss hospital-based surveillance of influenza and COVID-19Research Published on 2022-01-062022-10-31 Journal: Eurosurveillance [Category] COVID-19, SARS, [키워드] adjust adjusted Admission air-borne infections clinic cohort study competing confounders COVID-19 COVID-19 pandemic Cox regression died Epidemiology event Final hazard hazard ratio hospital ICU ICU admission In-hospital In-hospital death in-hospital mortality include Infection Influenza Influenza virus insight intensive care interquartile range male median Mortality outcome Patient patients with COVID-19 patients with influenza Probability Result retrospective RT-PCR Seasonal influenza secondary outcome Seven severe acute respiratory syndrome – SARS subdistribution Surveillance Switzerland the disease the patient viral infections Weighting with COVID-19 [DOI] 10.2807/1560-7917.ES.2022.27.1.2001848 PMC 바로가기 [Article Type] Research
Reduced risk of severe COVID-19 in more than 1.4 million elderly people aged 75 years and older vaccinated with mRNA-based vaccinesShort communication Published on 2022-01-012022-10-05 Journal: Vaccine [Category] SARS, 임상, [키워드] 95% confidence interval Adults age clinical trial COVID-19 COVID-19 hospitalization effective Effectiveness Epidemiology Follow-up hazard highlighting Hospitalization injection median mRNA vaccination mRNA-based vaccine Older Prevent public health Ratio reducing risk risk of COVID-19 risk reduction second dose severe COVID-19 Sex shown subject vaccination Vaccine [DOI] 10.1016/j.vaccine.2021.12.009 [Article Type] Short communication
Development of an Active Training Method for Belt ConveyorArticle Published on 2021-12-312022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] active training method concerning conducted Conducting Course COVID-19 pandemic develop development eight hazard human factor implementation methodology Occupational stress question receive Safe Stress training underground mining virus was selected work safety [DOI] 10.3390/ijerph19010437 PMC 바로가기 [Article Type] Article
Electromagnetic Exposure of Personnel Involved in Cardiac MRI Examinations in 1.5T, 3T and 7T ScannersArticle Published on 2021-12-222022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activity biomedical engineering calculated cardiac changes in convalescent COVID-19 defined distribution environmental engineering examination example exposure fraction hazard hypothesised increase magnetic resonance imaging majority medium movement-related vertigo MRI Probability profile radiology scanner significant increase significantly Static static magnetic field suggested Variability vertigo was recorded workers’ safety [DOI] 10.3390/ijerph19010076 PMC 바로가기 [Article Type] Article