Inactivation of Coronaviruses during Sample Preparation for Proteomics ExperimentsProteomics 실험을 위한 샘플 준비 중 코로나바이러스의 비활성화Article Published on 2021-09-032022-09-11 Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘, [키워드] absence Analysis analyzed applied biosafety buffer Care cells coronavirus Coronaviruses Cytopathic effect diagnostics FIVE HCoV HCoV-229E HCoV-OC43 human coronaviruses inactivated inactivation lysis lysis buffer mass mass spectrometry performed preparation proteomics quantitative real-time PCR room temperature Safe Sample sample preparation SARS-CoV-2 SARS-CoV-2 research SDS temperature urea was performed were used while [DOI] 10.1021/acs.jproteome.1c00320 PMC 바로가기 [Article Type] Article
Comparison of approaches to quantify SARS-CoV-2 in wastewater using RT-qPCR: Results and implications from a collaborative inter-laboratory study in CanadaRT-qPCR을 사용하여 폐수에서 SARS-CoV-2를 정량화하는 접근 방식의 비교: 캐나다의 공동 실험실 간 연구의 결과 및 의미Comparative Study Published on 2021-09-012022-09-11 Journal: Journal of environmental sciences (China) [Category] SARS, 치료기술, [키워드] 229E Aliquots Analysis approach approaches Canada Chain Reaction comparable Concentration condition coronavirus COVID-19 COVID-19 pandemic detection Effectiveness eight estimate evaluate expected fraction greater HCoV HCoV-229E human coronavirus implication inactivated Laboratory polymerase chain polymerase chain reaction protocol provided Public public health Quality Quality assurance Quality control Quantitative remained reported Result reverse transcription reverse transcription quantitative polymerase chain reaction RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA Surrogates Surveillance tested Variability wastewater wastewater surveillance [DOI] 10.1016/j.jes.2021.01.029 PMC 바로가기 [Article Type] Comparative Study
Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 SeverityCOVID-19 심각도에 대한 인간 코로나바이러스 229E에 대한 기존 항체의 잠재적 보호Article Published on 2021-08-272022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 진단, 치료기술, [키워드] 229E 95% CI Analysis antibodies antibody association Asymptomatic broad spectrum carried cause causes clinical manifestation clinical manifestations clinical symptom COVID-19 cross-sectional cross-sectional study develop disease explain female HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HKU1 human coronavirus Humoral immunity Infection manifestation Mild mild clinical symptom mild clinical symptoms moderate NL63 OC43 Participants Potential presence of antibody Prevent protection protective effect regression analysis SARS-CoV-2 SARS-COV-2 infection seasonal coronavirus seasonal coronaviruses seropositive seroprotection severe manifestations of COVID-19 severity statistical analysis subgroup analysis the SARS-CoV-2 variable virus viruses [DOI] 10.3390/ijerph18179058 PMC 바로가기 [Article Type] Article
AHR signaling is induced by infection with coronavirusesArticle Published on 2021-08-262022-10-04 Journal: Nature Communications [Category] MERS, SARS, 치료제, [키워드] activate activated Activation AhR Analysis antagonist antiviral immunity antiviral response antiviral therapy Aryl hydrocarbon receptor association boost common cold contribute coronavirus Coronaviruses COVID-19 pandemic COVID-19 patients decrease Dengue epithelial cell evade evaluate expression Future HCoV-229E Host Human illnesses immune response in vitro in vivo increased expression Infection Infectious diseases life-threatening limit Lung epithelial cells Lung pathology lung tissue Medical research Mild pathology pharmacological promote Replication Respiratory failure respiratory tract restrict RNA viruses SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 replication severity Signaling single-cell RNA-seq suppressed targets transcriptional Viral load viral replication viral titer Zika [DOI] 10.1038/s41467-021-25412-x PMC 바로가기 [Article Type] Article
Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 VirusArticle Published on 2021-08-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 50% effective concentration activity addition Antiviral antiviral activity antiviral drug Antiviral effect Arbidol Cell China combating coronavirus Coronaviruses COVID-19 early stage EC50 EC50 value effective evaluated HCoV-229E HCoV-OC43 Health in vitro assays Including Infection inhibited log novel novel SARS-CoV-2 virus pandemic Plaque assay Prophylaxis replication of SARS-CoV-2 repurposing respiratory viral infections Russia Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 virus sensitivity shown significantly Spectrum suppressed treatment of influenza umifenovir VERO E6 cells virus viruses [DOI] 10.3390/v13081665 PMC 바로가기 [Article Type] Article
Epidemiological and co-infection characteristics of common human coronaviruses in Shanghai, 2015–2020: a retrospective observational studyResearch Article Published on 2021-08-182023-07-01 Journal: Emerging Microbes & Infections [Category] SARS, [키워드] Co-infection HCoV-229E HCoV-OC43 human coronavirus respiratory pathogen SARS-CoV-2 [DOI] 10.1080/22221751.2021.1965498 PMC 바로가기 [Article Type] Research Article
Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in AustraliaBrief Report Published on 2021-08-162022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] antibody Asymptomatic blood donor convalescent sera coronavirus COVID-19 pandemic detectable geometric mean titre HCoV-229E HCoV-NL63 healthy healthy adults immune response increasing age individual Infection median microneutralisation assay modulate neutralising antibody neutralising antibody titre not differ pathogenic coronaviruses plasma plasma samples Post-infection quantified R 2 reported response SARS-CoV-1 patients SARS-COV-2 infection Sex symptomatic tested the healthy titre utility was performed [DOI] 10.3390/v13081618 PMC 바로가기 [Article Type] Brief Report
Evolutionary trajectory of SARS-CoV-2 and emerging variantsSARS-COV-2 및 신흥 변종의 진화 궤적Review Published on 2021-08-132022-09-10 Journal: Virology Journal [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals coronavirus CoV CoVs Cross-species transmission demonstrated Endemic Evolution Factor HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs highlight highlighting HKU1 Human human coronavirus independent Infection MERS MERS-CoV Mutation mutations neutralization Novel coronavirus OC43 pathogenic pathogenicity Protein respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected Selection severe acute respiratory syndrome Coronavirus severe disease trajectory vaccine-mediated immunity variant variants variants of concern virus Virus evolution virus transmission VoC while [DOI] 10.1186/s12985-021-01633-w PMC 바로가기 [Article Type] Review
Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses교차 중화 항체 반응의 정량화를위한 모든 순환 인간 코로나 바이러스에 대한 코로나 바이러스 의사 타입Article Published on 2021-08-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 antibody antibody cross-reactivity Antibody neutralization best Betacoronavirus breadth can be used Cell cell line cells CHO cell CHO cells Clinical outcome condition coronavirus COVID-19 COVID-19 disease COVID-2019 cross-reactivity disease Disease progression Effect Endemic envelope Haemagglutinin HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HEK293T HKU1 HUH7 cells Human human coronavirus Immunity immunopathology lentiviral MERS MERS-CoV natural infection neutralization Neutralizing NL63 Novel coronavirus novel coronavirus SARS-CoV-2 OC43 pre-existing immunity produced progression Protein Proteins provide pseudotype pseudotype virus pseudotype viruses Pseudotyped virus Research question response Safe SARS-CoV-1 SARS-CoV-2 seasonal coronavirus serological Seropositivity Seven surface proteins target cell target cells the SARS-CoV-2 titre TMPRSS2 TMPRSS2 expression transduced transfected with understanding vaccination viruses [DOI] 10.3390/v13081579 PMC 바로가기 [Article Type] Article
Assessment of Antiviral Coatings for High-Touch Surfaces by Using Human Coronaviruses HCoV-229E and SARS-CoV-2Methods Published on 2021-07-212022-10-28 Journal: Applied and Environmental Microbiology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Ammonium Antiviral antiviral activity antiviral coating Antiviral effect approach assessment benefit coated coating conditions coronavirus coronavirus disease COVID-19 criteria criterion demonstrated Effect Efficacy evaluate Evidence experiments HCoV-229E Human human coronavirus human coronavirus 229E Influenza virus less mitigate offer pandemic reactive oxygen specy repeated Respiratory droplets respiratory virus responsible risk risk of transmission robust SARS-CoV-2 SARS-CoV-2 transmission surface survival Transmission transmitted viral log reduction virus viruses [DOI] 10.1128/AEM.01098-21 PMC 바로가기 [Article Type] Methods