Hemorrhagic and thrombotic manifestations in the central nervous system in COVID-19: A large observational study in the Brazilian Amazon with a complete autopsy seriesCOVID-19의 중추 신경계에서 출혈 및 혈전 증상 : 완전한 부검 시리즈를 가진 브라질 아마존의 대규모 관찰 연구Observational Study Published on 2021-09-102022-09-10 Journal: PLoS ONE [Category] 변종, 임상, [키워드] 95% CI absence Affect Analysis antibiotic Anticoagulant association Autopsies Autopsy Brain Brazil broad spectrum Central nervous system clinical clinical manifestations clinician CNS Comorbidities Comorbidity Complete conditions confidence interval Corticosteroid COVID-19 described diabete diabetes different clinical manifestations discharge drug events gross examination had no hemorrhage hemorrhages Hemorrhagic hemorrhagic lesion hemorrhagic lesions hemorrhaging higher risk imperative indicate individual Infection Intervention involved laboratory characteristics Lungs manifestation Manifestations Microscopy nervous system neurological neurological manifestations outcome pathology Patient patients with COVID-19 perivascular positive Prevent protocol radiologic radiological finding Rapid test Relative risk risk Risk assessment RT-PCR SARS-CoV-2 serological statistical statistical significance subarachnoid hemorrhage the disease thrombotic Thrombotic events to define treat two groups variant virus [DOI] 10.1371/journal.pone.0255950 PMC 바로가기 [Article Type] Observational Study
Characterization of epidemiological distribution and outcome of COVID-19 in patients with hereditary hemorrhagic telangiectasia: a nationwide retrospective multi-centre study during first wave in Italy유전성 출혈성 모세혈관확장증 환자에서 COVID-19의 역학적 분포 및 결과의 특성화: 이탈리아의 첫 번째 물결 동안 전국적인 후향적 다기관 연구Multicenter Study Published on 2021-09-082022-09-12 Journal: Orphanet Journal of Rare Diseases [Category] SARS, 진단, [키워드] addressed adverse outcome Affect Analysis approach bleeding characterization characterized clinical condition clinical feature Clinical features co-morbidity collected Complication concerning coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 in patient COVID-19 infection cross-sectional design disease disorders distribution Epidemic epidemiological estimates evidenced Factor First wave foci Frequency General population geographical distribution Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia Hospital admission Infection infection risk intensive care Italian Italy laboratory confirmation lombardy management manifestation morbidities objective outcome outcomes overlapping pandemic PANDEMICS 2020 Patient patients Personal protective equipment Protective questionnaire rare diseases reported Result retrospective risk risk factor Risk factors SARS-COV-2 infection secondary to severe COVID-19 susceptibility telangiectasia Vascular visceral was recorded [DOI] 10.1186/s13023-021-02000-2 PMC 바로가기 [Article Type] Multicenter Study
Spontaneous massive hemothorax as a complication of necrotizing pneumonia in a patient with severe acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndrome: a case reportCase Report Published on 2021-09-032022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Admission ARDS bleeding bleeding event Case report Causative caused Combination Complication coronavirus coronavirus disease COVID-19 Deterioration develop discharged elevated extracorporeal membrane oxygenation fibrinous pneumonia Hemorrhagic Hemothorax histopathological examination hospital Hospital admission Inflammatory marker initial lung Lung function Mild Necrosis Necrotizing pneumonia Patient prone positioning Protective pulmonary hemorrhage rehabilitation shifting Shock Spontaneous supplementary material Support syndrome the patient tissue Ventilation [DOI] 10.1186/s13256-021-03032-9 PMC 바로가기 [Article Type] Case Report
Association of ABO and Rh blood groups with obstetric outcomes in SARS-CoV-2 infected pregnancies: A prospective study with a multivariate analysisObservational Study Published on 2021-09-012022-10-05 Journal: European journal of obstetrics, gynecology, and re [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval ABO ABO blood group adjusted odds ratio age Analysis analyzed association Blood Blood Group Cohort collected complications coronavirus COVID-19 difference disease susceptibility distribution Emergency evaluate group groups hemorrhage Hemorrhagic hemorrhagic events lower risk Maternal maternal age Maternal morbidity membrane morbidity mother Neonatal Mortality Obstetric outcome Patient performed pregnancies Pregnancy pregnant women Premature Prospective Prospective Study Rh+ rupture SARS-CoV-2 Spanish Stillbirth symptomatic tested women [DOI] 10.1016/j.ejogrb.2021.07.008 PMC 바로가기 [Article Type] Observational Study
Neuropathology and Inflammatory Cell Characterization in 10 Autoptic COVID-19 BrainsArticle Published on 2021-08-312022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] addition Affect age Brain brain autopsy cause changes characterization Comorbidities COVID-19 COVID-19 patients described Encephalopathy feature Hemorrhagic highlighting hypoxic Infection Inflammation Injury knowledge Laboratory safety lesion macrophages microvascular injury nervous system neurological manifestations Neurological symptoms neuronal Neuropathology Patient perivascular inflammation Post-mortem SARS-CoV-2 SARS-COV-2 infection Support surviving patient T cell Vascular [DOI] 10.3390/cells10092262 PMC 바로가기 [Article Type] Article
Multi-Organ Histopathological Changes in a Mouse Hepatitis Virus Model of COVID-19Article Published on 2021-08-272022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] alveolar animal model Asymptomatic Blood blood vessels Brain bronchiolar capillary cause Cell change changes characterized cortical COVID-19 COVID-19 pandemic Cytokine storm death distal edema epithelial hemorrhage Hemorrhagic Hepatitis Human humans hyaline membrane formation infect Infection infiltration inoculated interstitial interstitial tissue intra-alveolar liver macrophages mechanism mice Mild Model moderate mononuclear cell mouse mouse hepatitis virus-1 multiorgan histopathology Necrosis necrotic necrotic debris Neuron nuclei organ system oxidative stress pathophysiologic peribronchiolar perivascular Pneumonia precipitated red blood cells renal reported representing Respiratory illness responsible Safe SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection Septic shock severe lung inflammation severe symptom therapeutic interventions thrombosis thrombotic event Tubular Necrosis uninfected vascular congestion vascular defect vessels virus was used weight loss widespread [DOI] 10.3390/v13091703 PMC 바로가기 [Article Type] Article
An immunoinformatics study: designing multivalent T-cell epitope vaccine against canine circovirusResearch Published on 2021-08-182022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] adjuvant Algorithm Amino acid ANN Antigen artificial canine Canine circovirus CAP cause conducted Dog leukocyte antigen epitope epitope vaccine Epitopes Escherichia coli expressed expression gastroenteritis Genome Hemorrhagic immune response immunoinformatics In silico cloning In silico methods in vitro in vivo experiments infections leukocyte linker molecular docking molecular dynamic simulations Molecular dynamics simulation Open reading frame opposite ORFs pathogen peptide-based vaccine performed Protein Result Screening selected selected epitope stability T-cell the vaccine Transcription vaccine construct Vaccine designing Vasculitis were used [DOI] 10.1186/s43141-021-00220-4 PMC 바로가기 [Article Type] Research
Critical illness-associated cerebral microbleeds for patients with severe COVID-19: etiologic hypotheses중증 COVID-19 환자의 중병 관련 뇌 미세 출혈: 병인 가설Article Published on 2021-08-012022-09-11 Journal: Journal of Neurology [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Atypical blood-brain barrier Brain brain MRI Concentration control patient COVID-19 COVID-19 infections COVID-19 outbreak creatinine Critical Critical illness D-dimers described dialysis dysfunction Endotracheal intubation extracorporeal membrane oxygenation Hemorrhagic hypothese Hypothesis Hypoxemia ICU intensive care unit intensive care units introduced kidney Kidney failure manifestation mechanism microangiopathy Microhemorrhages. MRI neurologic Patient patients respiratory distress Respiratory distress syndrome Respiratory failure secondary to Severe COVID-19 Infection severe COVID-19 infections severe COVID-19 patients syndrome tendency tested thrombotic thrombotic event toxin university uremic was performed White matter with COVID-19 [DOI] 10.1007/s00415-020-10313-8 PMC 바로가기 [Article Type] Article
Acute symptomatic seizures and COVID-19: Hospital-based studyObservational Study Published on 2021-08-012022-10-05 Journal: Epilepsy research [Category] SARS, 임상, [키워드] Aswan Blood Brain C-reactive protein cerebrovascular Cerebrovascular stroke CNS Coagulation complete blood picture Computed tomography COVID COVID-19 COVID-19 infection diagnosed Encephalitis epilepsy explain Frequency functions Hemorrhagic hospital laboratory investigation liver magnetic resonance imaging majority material MRI Occurrence pathology pathophysiological mechanisms Patient patients patients with COVID-19 renal Seizure Seizures serum stroke suffered symptomatic university with COVID-19 [DOI] 10.1016/j.eplepsyres.2021.106650 PMC 바로가기 [Article Type] Observational Study
Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case ReportCase Report Published on 2021-07-302022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] aquired association AstraZeneca caused ChAdOx1 ChAdOx1 nCoV-19 coagulation disorder Complication complications country COVID vaccination COVID-19 infections Efficacy Europe Hemorrhagic immune Immune thrombocytopenia Infectious diseases ITP ITP associated with AstraZeneca Covid vaccination ITP associated with Covid vaccination less life-threatening management media mRNA novel performed platelet pathology / inherited prothrombotic report reported secondary secondary ITP shown Side effect symptomatic thrombocytopenia thrombotic vaccination Vaccinations Vaccine [DOI] 10.1055/s-0041-1731774 PMC 바로가기 [Article Type] Case Report