NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterraneaNF-YB는 Planarian Schmidtea 지중해에서 정자 줄기 세포 자가 재생 및 증식을 조절합니다Research Article Published on 2016-06-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] balance carrier causative agent Cell cell population cell proliferation cells combating complex component conserved coordination developmental differentiation disease Disruption etiology Factor fecundity Gamete genetic information germ cell germ cells help homolog identification implication Implications infertility inhibited involved lead life maintenance male mechanism morbidity observation open organism Organisms parasite Pathogenesis Planarian proliferation Propagation reproductive required Schistosoma mansoni schistosome Schistosomiasis Sperm SSC STEM stem cell stem cells testes transcription factors Transmission tropical tropical disease Tumor tumorigenesis tumors [DOI] 10.1371/journal.pgen.1006109 PMC 바로가기 [Article Type] Research Article
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive보존된 DNA 반복은 게놈 아카이브에서 트리파노소마 브루세이 표면 항원의 다양한 레퍼토리 선택을 촉진합니다Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated addition African African trypanosomiasis antigenic variation archive assumption bloodstream catastrophic Cell cell cycle Chromosomal translocation Chromosomal translocations chromosome chronic condition conserved demonstrated DNA DNA sequence Donor event expression gene conversion genetic change Genome genomic homolog homology Host Hypothesis identify implicated induce infect Infection iteration mammalian manipulation natural infection observation observé outcome parasite pathogen Pathogens promote Protein proximal Recombination recombination event reduction in Region Repeat repertoire required selected Selection sequence silent species Support surface Surface glycoprotein switching synthetic tested the cell These data transcribed translocation Trypanosoma Trypanosoma brucei Trypanosome trypanosomiasis Variant Surface Glycoprotein VSG [DOI] 10.1371/journal.pgen.1005994 PMC 바로가기 [Article Type] Research Article
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L ActivationResearch Article Published on 2016-03-292022-10-29 Journal: mBio [Category] Coronavirus, [키워드] accessory protein activate Activation acute respiratory syndrome antiviral activity betacoronavirus calu-3 cells cell death characterized cleave contribute coronavirus Coronaviruses CoV Critical cytoplasmic dsRNA enzyme expressed expression level genes encoding Genome highly pathogenic homolog Host host antiviral response host innate immunity IFN IFN signaling in vivo model inactivation Infection Innate immunity interferon involved Like Lineage mechanism MERS MERS-CoV MERS-CoV infection Middle East murine mutant NLS NS2 NS4b nuclear localization signal nucleus offer other coronaviruses Pathogenesis pathway potential mechanism Prevent Protein provide Replication reported required respiratory respiratory syndrome coronavirus RNA RNase SARS-CoV single-stranded Spread ssRNA subsequent therapeutic intervention translational type I interferon viral double-stranded RNA viral pathogenesis viral replication virulence [DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article
Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia글리신과 엽산은 선천적 철모구성 빈혈의 모델을 개선합니다.Research Article Published on 2016-01-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 5-Ala 5-aminolevulinic acid addition Anemia anemic autosomal recessive biosynthetic pathway Blood blood cell Blood Transfusion Cell congenital congenital sideroblastic anemia derivative determine downstream effective exogenous glycine exogenously family member folate glycine glycine cleavage system Hem25 heme heme biosynthetic pathway heme synthesis hemoglobin homolog humans identify inherited anemia inherited anemias iron iron chelation knowledge metabolite Mitochondria mitochondrial mitochondrial glycine importer mitochondrial glycine importers mitochondrial glycine transporter mitochondrial glycine transporters Model molecular Mutation Patient precursors Protein red blood cell red blood cells required restore hemoglobin level restore hemoglobin levels Safe sideroblastic anemia Sideroblastic anemias SLC25 SLC25A38 synthesis the disease Tolerability Treatment Vitamin while yeast yeast cell yeast cells Ymc1 zebrafish [DOI] 10.1371/journal.pgen.1005783 PMC 바로가기 [Article Type] Research Article
PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase CPRO40은 MAP 키나제 모듈을 업스트림 활성제 단백질 키나제 C에 연결하는 세포벽 무결성 경로의 스캐폴드 단백질입니다.Research Article Published on 2014-09-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activator adapter adapters Affinity purification Alzheimer's disease approach ascomycete asexual development bind Cancer Cell cell differentiation Cell fusion cell wall characterized combating conserved Control deletion mutant deletion mutants determinant developmental developmental processe developmental processes disease domain ENCODE environmental cue environmental cues eukaryote eukaryotes eukaryotic Evidence experiment Extensive filamentous fungi fruiting bodies fungal fungi fungus Genetic growth homolog implicated integrity Interaction interaction partner involved kinase MAPK mass spectrometry mitogen mitogen-activated protein kinase module molecular MOST mutant mutated N-terminal Pathogenesis pathogenicity pathway Pathways Phosphorylation polar Protein protein kinase protein kinase C Regulation required scaffold protein Signal transduction Signaling Sordaria macrospora Stress stress response symbiosis the cell upstream vegetative growth wall yeast [DOI] 10.1371/journal.pgen.1004582 PMC 바로가기 [Article Type] Research Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters Complexes complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity타고난 면역에 대한 결과와 함께 전사 조절에서 RBF1 및 dCAP-D3의 공유 역할Research Article Published on 2012-04-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation affected Alter AMP AMPs antimicrobial peptide Author Bacteria Bacterial infection Bacterial pathogens Cell cell cycle cell cycle arrest cell cycle gene cell cycle genes chromatin chromatin condensation classic Cluster condensation Condensin consequence conserved decrease DNA Drosophila Drosophila melanogaster expression fat function Gene gene cluster gene clusters Genes homolog homologs human cell human cells identify immune response immune system in vivo induce Infection Innate innate immune genes Innate immunity Interaction mitosis mitotic Pathogens peptide pRB previous study promote Protein Proteins RBF1 Region regulate regulated Regulation repress retinoblastoma retinoblastoma protein role shown subset subunit suggested transcript Transcription Tumor tumor suppressor undergo unique [DOI] 10.1371/journal.pgen.1002618 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci6개의 1형 당뇨병 코호트에 대한 게놈 전체 메타 분석으로 여러 관련 유전자좌 식별Research Article Published on 2011-09-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADCY3 affected association Author C6orf120 CENPO chromosomal combined cohort contributing to controls dataset diabete diabetes disease DLL1 DNAJC27 DNMT3A domain EFR3B examined excess FAM120B Follow-up Gene gene network gene networks Genes Genetic genetic component genetic loci genetic screening Genome Genome-wide association studies Genome-wide association study genome-wide significance genotyped GWAS homolog hypotheses identify Impact independent intergenic region intronic region investigator investigators Linkage disequilibrium LMO7 LOC154449 loci meta-analyses Meta-analysis Multiple NCOA1 Pathogenesis PHF10 POMC Protein PSMB1 reached recent finding Region replicated risk risk for disease significantly SNP SNPs susceptibility T1D TBP the disease Type Type 1 diabetes variant variants WDR27 [DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article