hospitalized COVID-19 patients – Page 6 – Communicable Diseases Research

Definition of the Immune Parameters Related to COVID-19 Severity

COVID-19 심각도와 관련된 면역 매개변수의 정의

Article

Published on 2022-03-182022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Admission allocation among others Analysis analyzed Blood blood cell blood cell count caused Cell changes in clinical decision Clinical management Cohort coronavirus COVID-19 COVID-19 outcome COVID-19 patients Critical Cutoff defined Definition described disease disease severity fluctuations for inclusion granulocyte groups highlight Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients immunological immunological changes intensive care intensive care unit admission Laboratory Laboratory test lymphocyte Medical resources Mild moderate non-survivor offer outcome oxygen oxygen support Oxygen therapy parameter Patient Peripheral blood peripheral blood cell peripheral blood cells predict Predictive proof recorded ROC Curve sensitivity separated severe acute respiratory syndrome Coronavirus severity Severity of disease Severity Score specificity survival survivor symptomatic the disease therapy Triage
[DOI] 10.3389/fimmu.2022.850846 PMC 바로가기 [Article Type] Article

Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab

중화 단일클론항체 밤라니비맙 치료 후 코로나19로 입원한 환자의 비인두 면봉 유전자 발현 패턴과 혈청 바이오마커 간의 관계

Randomized Controlled Trial

Published on 2022-03-182022-09-11
Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술,

[키워드] absence Analysis Analytes antibody formation Antibody Response approach bamlanivimab Biomarker biomarker signature Biomarkers Blood change changes in circulation clinical clinical trial Cohort collected connection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL10 CXCL11 detect disease Elecsys Gene Expression gene expression pattern groups healthy control healthy controls Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IFNγ IgA IgG titer IgG titers IgM IL-6 immune response immunoassay immunological implementation Infection Inflammatory inflammatory protein Inflammatory response interferon response Level Luminex MCP-3 MONITOR monoclonal antibody nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs Neutralizing not affect not significantly different observation observations Patient patient population patients patients hospitalized patients with COVID-19 peaked Peripheral blood Placebo presence or absence profile Protein Randomized receive reductions reductions in relationship remained repeated measure respiratory RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seroconversion serology serum serum biomarker Serum protein serum proteins serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarities single dose systemic disease therapeutic Treatment Treatment strategies utility viral-induced was performed was used were used while with COVID-19
[DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial

Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients

호중구 세포외 트랩의 혈장 표지자는 COVID-19 관련 ARDS 환자의 생존과 관련이 있지만 폐색전증과는 관련이 없습니다

Article

Published on 2022-03-172022-09-11
Journal: Frontiers in Immunology [Category] MERS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome Admission Analysis ARDS Biomarker circulating Clinical outcome clinical outcomes collected Comparisons complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression develop Embolism evaluate Extracellular hospital hospitalized COVID-19 patient hospitalized COVID-19 patients Hypothesis immunothrombosis life-threatening lung damage Mann-Whitney test marker microthrombus moderate disease myeloperoxidase NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps non-survivor Non-survivors Occurrence Patient patients patients hospitalized plasma Plasma levels Prevent pulmonary Pulmonary embolism recent respiratory distress Respiratory distress syndrome responsible restriction severe COVID-19 patients severe disease severe patients survival survivor syndrome therapeutic target total DNA TRAP were assessed with COVID-19 worsening
[DOI] 10.3389/fimmu.2022.851497 PMC 바로가기 [Article Type] Article

Specialized interferon action in COVID-19

코로나19에 특화된 인터페론 작용

Article

Published on 2022-03-152022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘, 진단,

[키워드] Activation Antiviral association C-reactive protein cell types circulating clinical marker clinical markers COVID-19 COVID-19 pathology CyTOF cytokine diagnostic disease severity Effect endothelial damage example Hospitalization hospitalized COVID-19 patients IFN IFN signaling IFNA2 IFNA6 IFNB1 IFNg IFNs Immune cell immune cell types immune cells immune marker Impact Implications interferon Kynurenine Kynurenine pathway lymphocyte lymphoid marker neutrophil pathology platelet activation poor prognosis Protective proteomics SARS-CoV-2 Seroconversion severe disease Signaling significant decrease subset the strongest therapeutic transcriptional response type I unique
[DOI] 10.1073/pnas.2116730119 PMC 바로가기 [Article Type] Article

Association of renalase with clinical outcomes in hospitalized patients with COVID-19

Research Article

Published on 2022-03-082022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS, SARS,

[키워드] 95% CI Admission age Anti-inflammatory Apoptosis Blood blood sample Cardiopulmonary Clinical data Clinical outcome collected Comorbidity COVID-19 COVID-19 disease COVID-19 patients CPR cytokine level death disease severity enrolled Future group Health hospital hospitalized COVID-19 hospitalized COVID-19 patients hospitalized patient hypoxia ICU admission IL-6 level increase in increased survival Inflammation initial intensive care intubation males Mortality outcome pathophysiological Patient reduced Research retrospective cohort study risk of death secondary secreted severe COVID-19 subject survival vasopressors were excluded were measured with COVID-19
[DOI] 10.1371/journal.pone.0264178 PMC 바로가기 [Article Type] Research Article

Plasma Biomarkers of Neuropathogenesis in Hospitalized Patients With COVID-19 and Those With Postacute Sequelae of SARS-CoV-2 Infection

입원한 COVID-19 환자 및 SARS-CoV-2 감염의 급성 후유증이 있는 환자의 신경병증 발생에 대한 혈장 바이오마커

Article

Published on 2022-03-072022-09-11
Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료법,

[키워드] Acidic Activation addition Antigen antigenemia antigenic antigenic stimulation Anxiety assessments association biochemical evidence Blood calculated CNS cognitive concentrations coronavirus correlated COVID-19 COVID-19 disease detectable detection develop diagnosis of COVID-19 dysfunction Encephalopathy enrolled Evidence evidence of exhibited groups healthy control Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infection initial Injury latent infection life light chain manifestation Measures Mild neurologic neuronal Neuropathogenesis Neuropsychiatric nucleocapsid antigen occur Older PASC pathogenic mechanism pathogenic mechanisms Patient patients patients hospitalized plasma plasma biomarker PNP presenting Protein recruited required respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 N Simoa Study participants subjects Symptom Symptoms symptoms onset These data were measured with COVID-19
[DOI] 10.1212/NXI.0000000000001151 PMC 바로가기 [Article Type] Article

Effectiveness of tocilizumab in the treatment of hospitalized adults COVID-19: A systematic review and meta-analysis

입원한 성인 COVID-19 치료에서 토실리주맙의 효과: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2022-03-042022-09-11
Journal: Medicine [Category] SARS, 임상, 진단,

[키워드] 30-Day mortality 95% CI 95% confidence interval Admission Analysis assigned clinical control groups Controlled controlled trials coronavirus coronavirus disease COVID-19 COVID-19 patients death determine discharge Effectiveness hazard ratio Health Health Organization Hospitalized hospitalized COVID-19 patients incidence Infection intensive care intensive care unit admission mechanical ventilation Meta-analysis meta-analysis model Mortality optimal dose outcome Patient performed random-effect Randomized controlled trial Randomized controlled trials Randomly receive reduced registry Relative risk required review risk searched Serious Adverse Event Serious Adverse Events significantly Spread systematic review Tocilizumab Treatment usual care usual care alone was used with COVID-19 World Health Organization
[DOI] 10.1097/MD.0000000000028967 PMC 바로가기 [Article Type] Meta-Analysis

Organ function biomarker abnormalities, associated factors and disease outcome among hospitalized patients with COVID-19

COVID-19를 가진 입원 환자의 장기 기능 바이오 마커 이상, 관련 요인 및 질병 결과

Research Article

Published on 2022-03-022022-09-10
Journal: Biomarkers in Medicine [Category] COVID19(2023년), Fulltext, SARS, 바이오마커,

[키워드] 95% CI Abnormalities Addis Ababa adjusted odds ratio Alanine Alanine transaminase alkaline phosphatase AOR aspartate Aspartate transaminase association Biomarker Biomarkers cardiac marker center co-morbidity conducted COVID-19 COVID-19 patient Critical critical patients determine disease disease severity elevated Ethiopia Factor hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients liver function tests magnitude male marker median age morbidity Mortality Organ failure organ function outcome P-value Patient phosphatase prospective cohort study renal function tests significantly study participant to define with COVID-19
[DOI] 10.2217/bmm-2021-0681 PMC 바로가기 [Article Type] Research Article

Combined Role of Troponin and Natriuretic Peptides Measurements in Patients With Covid-19 (from the Cardio-COVID-Italy Multicenter Study)

Research article

Published on 2022-03-012022-10-05
Journal: The American journal of cardiology [Category] SARS, 바이오마커,

[키워드] 95% confidence interval Acute heart failure Admission age available data Biomarker Chronic kidney disease Combined concerning consecutive patient coronary syndrome COVID-19 patients Cox regression analysis death defined Diagnosis died elevated evaluate follow-up period Gender greater hazard ratio higher risk hospitalized COVID-19 patients limit measurement median men multicenter study Natriuretic oxygen saturation Patient patients with COVID-19 peptide Predictive prognostic Prognostic value provided recruited remained risk stratification role troponin troponin level were excluded with COVID-19 worse prognosis
[DOI] 10.1016/j.amjcard.2021.11.054 [Article Type] Research article

Computed tomography findings and prognosis in older COVID-19 patients

Research

Published on 2022-03-012022-10-27
Journal: BMC Geriatrics [Category] COVID-19,

[키워드] 95%CI Affect age calculated Chest CT chest CT scan chronic condition Cluster Clusters Computed tomography confounders consolidation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT finding CT findings enrolled GGO hazard ratio hierarchical clustering hospitalized COVID-19 patients identify implication independent Mortality multicenter multivariable model Old Older older patient older patients Oldest patients Pleural pleural effusion Pneumonia Prevalence prevalent Prognosis prognostic Prognostic marker reflect Result risk of death SARS-CoV-2 severity stratified supplementary material the patient tomography Validity was performed X-ray computed
[DOI] 10.1186/s12877-022-02837-7 PMC 바로가기 [Article Type] Research