Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters프로테오솜 보조제가 첨가된 SARS-CoV-2 스파이크 단백질 기반 백신을 사용한 비강내 면역은 마우스와 햄스터에서 면역원성과 효능이 있습니다.Article Published on 2022-06-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Antigen B.1.351 B.1.617.2 Beta binding Blood body weight Body weight loss cellular Delta disease evaluated Formulation hamster help IgA titers IgG immune responses immunization immunogenic intranasal Lungs mice mucosal mucosal surface Neutralizing activity offer pandemic persistence prefusion Prevent profile protective immune response Protein protein subunit vaccine reduce reducing reference strain resistin robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine serum antibodies serum antibody spike Spike protein Subunit vaccine the SARS-CoV-2 Vaccine variants variants of concern Viral viral entry Viral load viral spike protein weight loss [DOI] 10.1038/s41598-022-13819-5 PMC 바로가기 [Article Type] Article
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2전신 중화 항체와 국소 면역 반응은 SARS-CoV-2의 통제에 중요합니다Article Published on 2022-06-102022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration approved Brain cell-mediated immune response complex Control Correlate of protection COVID-19 COVID-19 vaccines Critical dissemination DNA Efficacy elicited heterologous vaccine humoral humoral responses immune response immunization immunogenic intramuscular intranasal Local lung mucosal mucosal immunity nanovaccine Neutralizing Parenteral Plasmid prevented Protective reduced response SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serum systemic T-cell immune response transgenic mice used to evaluate Vaccine viral burden viral replication [DOI] 10.3390/v14061262 PMC 바로가기 [Article Type] Article
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Research Published on 2022-06-022022-10-05 Journal: Nature biotechnology [Category] Coronavirus, 진단, [키워드] administration Alzheimer’s disease amyloid precursor protein approved Cell cell types Central nervous system CNS conjugate Efficacy evaluated hepatocyte intranasal intravitreal knockdown liver lung non-human primate organs physiological Region resulting RNA RNA interference rodent Safe siRNA siRNAs specificity sustained target gene therapeutic Therapeutics tissue [DOI] 10.1038/s41587-022-01334-x [Article Type] Research
ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccinationChAdOx1-S 아데노바이러스 벡터백신을 비강내 투여하여 근육주사에 비해 점막면역력이 우수함Article Published on 2022-06-012022-09-12 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adenoviral vector adenoviral vector vaccine Administered Antibody titer applied approved BALB/c mice breakthrough infections CD8 T cell Cellular immune response ChAdOx1-S Complete COVID-19 COVID-19 pandemic elicit elicited exhibiting expressing form full-length humoral IgA IgG antibody Immunity immunization immunized immunized mice induce intramuscular intramuscular vaccination intramuscularly intranasal intranasally lung mice mucosa mucosal mucosal immunity neutralized neutralizing capacity percentage phenotype Prevent Protein robust SARS-CoV-2 sera spike the disease the Spike tissue vaccination Vaccine vaccine vectors. vectors virus entry [DOI] 10.1002/eji.202249823 PMC 바로가기 [Article Type] Article
Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19COVID-19에 대한 비강내 예방으로서 광범위한 변이 활성을 갖는 계란 유래 항-SARS-CoV-2 면역글로불린 Y(IgY)Clinical Trial Published on 2022-06-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 2019 novel coronavirus 2019-nCoV activity Administered Against Alpha anti-SARS-CoV-2 Antiviral approval approvals B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding capture chicken immunoglobulin clinical clinical trial clinical trial body Clinical use contagiousness Convalescent patients COVID-19 cross-reactivity Delta demonstrated develop Diseases distribution double-blind effective Emergency use authorization enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of greater healthy human tissue human tissues IgY Immunity immunized Immunoglobulin immunoglobulin Y index Infectious diseases intranasal intranasally multiple dose multiple doses nasal drop nasal drops nasal mucosa neutralization titer no evidence of Novel coronavirus omicron Phase 1 phase 1 study Placebo placebo-controlled Prevalence Prophylaxis raised Randomized RATs RBD Receptor-binding domain reduce reduced risk Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral sensitivity sera Spike protein the receptor-binding domain the SARS-CoV-2 Tolerability Transmission Trial Vaccine Vaccine hesitancy variants variants of concern variety Viral virus [DOI] 10.3389/fimmu.2022.899617 PMC 바로가기 [Article Type] Clinical Trial
Prolonged viral shedding identified from external splints and intranasal packings in immediately cured COVID-19 patients with nasal fractures: A retrospective study코 골절로 즉시 치료된 COVID-19 환자의 외부 부목과 비강 내 패킹에서 확인된 장기간의 바이러스 배출: 후향적 연구Article Published on 2022-06-012022-09-11 Journal: Journal of stomatology, oral and maxillofacial sur [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval age association Asymptomatic Cohort COVID COVID-19 COVID-19 patient COVID-19 patients cured Fracture Gender Hospital stay humans Infection intranasal level 1 Linear regression model Multiple multiple linear regression models nasal Nasal fracture Odds ratio operative Other outcome parameter Patient patients Pearson Prolonged prolonged viral shedding Re-infection reached repair retrospective cohort study Retrospective study Sample size SARS-CoV-2 separated severity statistical significance surgical surgical site symptomatic Transmission trauma treated Treatment variable viral shedding [DOI] 10.1016/j.jormas.2022.04.003 PMC 바로가기 [Article Type] Article
The paradigm shift in treatment from Covid-19 to oncology with mRNA vaccinesReview article Published on 2022-06-012022-10-05 Journal: Cancer treatment reviews [Category] COVID19(2023년), SARS, 치료법, [키워드] addition administration Antigen approach Cancer Cancer vaccine circumvent clinical study Combination coronavirus disease COVID-19 Efficacy Ex vivo Immunosuppression indications intranasal intravenous Isolation literature medication mRNA mRNA platform mRNA vaccine mRNA vaccines oncology optimization overcome patients platform Research reveal RNA therapeutic therapy treat Treatment Vaccine Vaccine design Vaccines [DOI] 10.1016/j.ctrv.2022.102405 [Article Type] Review article
Safety and Efficacy of Combined Intramuscular/Intranasal RAZI-COV PARS Vaccine Candidate Against SARS-CoV-2: A Preclinical Study in Several Animal ModelsSARS-CoV-2에 대한 결합된 근육내/비강내 RAZI-COV PARS 백신 후보의 안전성 및 효능: 여러 동물 모델에서의 전임상 연구Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence adjuvant administration Against Amino acid animal approval BALB/c mice blood chemistry candidate candidate vaccine Cellular immune response changes in clearance Combined control group COVID-19 different dose dose Efficacy Efficacy and safety evaluated hamster hamsters heterologous prime-boost High dose humoral IgA antibody immune immune response Immunity induce interval intramuscular intranasal intranasally Iran lung Lung pathology Lungs mice middle Model Modification monomeric mucosal N-terminal domain Neutralizing antibodies New NTD organs parameters Pathological examination pfu Placebo Preclinical Protective RAZI-COV PARS RBD regimens repeated robust Safety SARS-CoV-2 SARS-CoV-2 preclinical study SARS-CoV-2 spike protein significantly specific IgG antibody Spike protein Spread stimulated subunits tested the vaccine trimer vaccination Vaccine vaccine candidate viral infection virus virus load was performed [DOI] 10.3389/fimmu.2022.836745 PMC 바로가기 [Article Type] Article
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants재조합 RBD 백신의 비강내 투여는 오미크론이 포함된 SARS-CoV-2 변이체에 대한 장기 면역을 유도합니다Article Published on 2022-05-172022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration booster Cell coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 deficiency demonstrated Economy effective vaccine Emergency global health Health IgG antibody immune response immune responses Immunity immunization induce intramuscularly intranasal Local long-lasting lung lymph nodes memory T cell memory T cells mice Migration mucosal mutant strain Neutralizing omicron Omicron variants outbreak persistence proliferation protective immunity RBD required respiratory robust SARS-CoV-2 SARS-CoV-2 variant secretory IgA sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Strong suggested systemically T cells T-cell threat Vaccine vaccine candidate Vaccines variant variants waning immunity wild-type [DOI] 10.1038/s41392-022-01002-1 PMC 바로가기 [Article Type] Article