Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins병원체와 바이러스 효과 단백질에 의한 세포외 ISG15 신호 조절Article Published on 2020-06-162024-08-19 Journal: Cell Reports [Category] 살모넬라증, [키워드] ERVE Nairovirus vOTU foot and mouth disease virus Lbpro influenza B NS1 interferon-α/β interferon-γ ISG15 LFA-1 SARS-CoV-2/COVID-19 PLpro TLRs [DOI] 10.1016/j.celrep.2020.107772 PMC 바로가기 [Article Type] Article
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19Review Published on 2020-05-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome affecting antiviral therapy clinical trial Consensus coronavirus coronavirus disease coronavirus epidemics Coronavirus infections COVID-19 COVID-19 therapy cysteine proteases drugs DUBs enzyme evaluated expressed function host cell host’s immune response immune response IMPROVE in vitro Infection inhibitor innate immune response intrinsic ISG15 majority Modification multifunctional opportunity outbreak pandemic Papain-like protease Pathogenesis pathway patient survival Pleiotropic effects PLP PLP inhibitors polypeptides Prevent protease Protein Proteins regulate Regulatory required responsible SARS SARS-CoV2 second Spread stability target proteins therapeutic strategy treat Treatment ubiquitin Viral pneumonia viral replication [DOI] 10.3390/ijms21103492 PMC 바로가기 [Article Type] Review
ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus ReplicationArticle Published on 2017-09-122023-06-12 Journal: Journal of Virology [Category] E형 간염, Fulltext, [키워드] Hepatitis E virus (HEV) immunomodulation ISG15 Type I IFN signaling [DOI] 10.1128/JVI.00621-17 PMC 바로가기
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variantsResearch Article Published on 2017-05-182022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Antiviral Antiviral agents antiviral drug antiviral strategy applied approach binding blocked catalytic catalytic activity cellular cleaving complicate component Critical develop domain DUB Ebola effective enzyme Enzymes expression Health Hemorrhagic fever virus high affinity Host humans identify infect infected patient Infection prevention inhibit inhibited inhibitor inhibitors innate immune responses interferon ISG15 magnitude MERS-CoV MERS-CoV infection Middle East molecular interaction mRNA outbreak Outbreaks Papain-like protease pathogenic virus pathogenicity plants polyprotein potent progeny PROTECT Protein Protein design provide reduced Replication replicative respiratory syndrome coronavirus responsible selective similarity specificity stimulated suppress targets therapeutic therapy transgenic Treatment variant variety viral pathogen viral replicase polyprotein viral replication virus viruses while Zika virus [DOI] 10.1371/journal.ppat.1006372 PMC 바로가기 [Article Type] Research Article
Interferon-stimulated gene 15 in hepatitis B-related liver diseasesArticle Published on 2016-10-182023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] ISG15 polymorphism HBV infection ISG15 ISGlation liver diseases Pathology Section [DOI] 10.18632/oncotarget.11955 PMC 바로가기
Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Induces Gene Expression of Anti-viral Proteins and Inhibits Neuraminidase ActivityArticle Published on 2015-05-012023-06-25 Journal: Phytotherapy research : PTR [Category] 신종인플루엔자, [키워드] ISG15 MX2 neuraminidase PKR RNASEL Yu Ping Feng San [DOI] 10.1002/ptr.5290
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity결핍성 미코박테리아 질환에 대한 멘델리안 감수성: IFN-γ 면역의 선천적 결함의 유전적, 면역학적 및 임상적 특징Article Published on 2014-12-042024-08-19 Journal: Seminars in immunology [Category] 살모넬라증, [키워드] BCG IFN-γ IL-12 ISG15 mycobacteriosis Primary Immunodeficiency Tuberculosis [DOI] 10.1016/j.smim.2014.09.008 PMC 바로가기 [Article Type] Article
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseResearch Article Published on 2014-05-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 3D structure abrogated activate activated activity acute respiratory syndrome amino acid residue B-cell Basis binding cleaving complex coronavirus distal domain DUB ENCODE enzyme function Genome help higher affinity highlight Host host cell hydrolysis identify in viral inhibited innate immune response interact Interaction interferon involved ISG15 mechanism MERS Middle East molecular mutant mutated NFκB nuclear Papain-like protease Pathogenesis PLPro polyprotein post-translational modification Protease activity Protein Proteins provide reduced required residue residues respiratory reveal SARS virus SARS-CoV short circuit signaling molecule signaling pathway significantly similar study specificity stimulated substrate substrates thumb unique viral replication virus was determined X-ray [DOI] 10.1371/journal.ppat.1004113 PMC 바로가기 [Article Type] Research Article