Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection경도 높은 처리량 TCR 레퍼토리 프로파일링은 가벼운 COVID-19 감염 후 T 세포 기억 형성의 역학을 보여줍니다Short Report Published on 2021-01-052022-09-10 Journal: eLife [Category] 치료기술, [키워드] adaptive antibodies antiviral immune response caused CD4 CD8 changes in characteristic clonal expansion clone coronavirus COVID-19 COVID-19 infection COVID-19 patients cross-reactive cross-reactivity dataset Diversity donors fraction global pandemic Human immune memory immune response infected cell infected cells Infection killing longitudinal majority memory memory formation memory T memory T cell memory T cells Mild mild case motif Occurrence Participation Phenotypes RepSeq resulting reveal SARS-CoV-2 SARS-CoV-2 coronavirus Sequencing T cell T cells T-cell T-cell receptor T-cell Response TCR TCR sequence TCR sequences the SARS-CoV-2 virus-specific antibodies [DOI] 10.7554/eLife.63502 PMC 바로가기 [Article Type] Short Report
Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expressionResearch Article Published on 2021-01-052022-10-30 Journal: The Journal of General Virology [Category] COVID-19, SARS, [키워드] 40S 40S ribosomal subunit acute respiratory syndrome Amino acid antiviral drug assays attenuated vaccine Attenuated vaccines biochemical bioinformatics caused Characteristics conserved contributed coronavirus coronavirus disease COVID-19 Critical disease Efficiency experiment expression greater host gene expression Host gene expression inhibition infecting inhibited inhibiting inhibitor K164 killing lysine mechanism Modification nonstructural protein 1 pathogen Renilla luciferase reporter Research residue ribosomal subunit SARS-CoV SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 suppress Vaccine virus production [DOI] 10.1099/jgv.0.001513 PMC 바로가기 [Article Type] Research Article
Chinese Medicine in Fighting against Covid-19: Role and InspirationCovid-19와 싸우는 한의학: 역할과 영감Article Published on 2021-01-012022-08-31 Journal: Chinese journal of integrative medicine [Category] 변종, 신약개발, 치료제, [키워드] Artemisinin build caused Chinese Chinese medicine coronavirus COVID-19 current death demonstrated develop diagnosing driving drug drug candidate drug candidates Effect effective effective drug effective drugs Evidence Fighting herbal medicine Infection Innovation inspiration killing lead medical system Medicine mutant pandemic pathogen patients researcher resource role SARS-CoV-2 theory treasure Treatment Vaccine Vaccines virus [DOI] 10.1007/s11655-020-2860-x PMC 바로가기 [Article Type] Article
Aspergillosis Complicating Severe Coronavirus Disease심각한 코로나바이러스 질병을 복잡하게 만드는 아스페르길루스증Review Published on 2021-01-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] abnormality airway aspergillosis Aspergillus Case series case sery classic clearance Combined complications constellation coronavirus coronavirus disease COVID-19 Diagnosis disease epithelial Europe fungal infections fungi Immunocompromised Immunosuppression IMPROVE increasingly Influenza influenza infection invasive killing Lung disease neutropenia outcome outcomes Pathologies pathophysiology Patient Prospective pulmonary aspergillosis respiratory infections risk SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe viral pneumonia syndrome therapy Viral viral infection viral infections virus zoonoses [DOI] 10.3201/eid2701.202896 PMC 바로가기 [Article Type] Review
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine면역원성이 높고 효과적인 홍역 바이러스 기반 Th1 편향 코로나19 백신530 Published on 2020-12-222022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immunity addition analyzed antibody antiviral efficacy Arm backbone candidate caused CD4 CD8 Coronavirus-2 country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective effective immunity Effective vaccines effort experiments expressing full-length S protein functional immune response genomic position gravity hamster identify IgG antibody immune immune responses Immunity immunogenic immunopathology in vivo induce insertion killing measles measles vaccine platform measles virus mice modulated mouse mouse-adapted SARS-CoV-2 multifunctional Neutralizing Patient Protective public health respiratory response S protein S protein expression Safe SARS-CoV-2 SARS-CoV-2 spike glycoprotein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significance significantly lower situation solution spike glycoprotein Spread Support T cell T cell response T cell responses Th1 immune bias the SARS-CoV-2 Threats vaccination Vaccine vaccine candidate variant virus virus load yielding [DOI] 10.1073/pnas.2014468117 PMC 바로가기 [Article Type] 530
May the analysis of 1918 influenza pandemic give hints to imagine the possible magnitude of Corona Virus Disease-2019 (COVID-19)?Review Published on 2020-12-222022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] 1918 influenza Analysis antiviral therapy approach biologics Complete Corona coronavirus disease country COVID-19 COVID-19 pandemic diffusion Evidence Factor General population Host immune response include infected patients infecting Infection JAK-inhibitors killing knowledge magnitude measure monoclonal antibodies Neutral observé outcome pandemic Passive antibody administration press Result SARS-CoV-2 Spain Spanish Spanish influenza Spread treat Vaccines virus [DOI] 10.1186/s12967-020-02673-6 PMC 바로가기 [Article Type] Review
Race against death or starvation? COVID-19 and its impact on African populationsReview Published on 2020-12-162022-10-28 Journal: Public Health Reviews [Category] COVID-19, [키워드] Abstract Africa African Chinese conducted consequence coronavirus coronavirus disease country COVID-19 COVID-19 outbreak COVID-19 pandemic death dimensions disease economic impact Evidence exacerbate frontline healthcare worker GDP Google Scholar Government Health highest implementation instance killing Local management manifested measure mechanism Mortality National North pandemic Political crisis, Social impact Population race Region responsible Result resulting the disease turn virus was recorded Web of Science wrought Wuhan [DOI] 10.1186/s40985-020-00139-0 PMC 바로가기 [Article Type] Review
MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infectionPriority Research Paper Published on 2020-11-172022-10-28 Journal: Oncotarget [Category] COVID-19, [키워드] ACE2 ACE2 expression ACE2 mRNA Affect airway epithelial cells antiviral agent attenuate bronchial epithelial cells Cell cells cellular COVID-19 COVID-19 severity cytokine cytotoxicity Disease progression elevated expression G-CSF human cells IL-1α IL-6 immune response in some increase individual Inflammatory cytokine inflammatory cytokines IL-6 inhibit killing lentiviral lung cancer M-CSF MAPK MCP-1 MEK inhibitor natural NK cells NK-cell observed correlation pathway Patient Patients with cancer plasma Population pRB proliferative promote Protein pseudovirus pseudovirus infection reduce Regulation Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-S stimulate stimulated suppress suppressed TMPRSS2 TMPRSS2 protease TRAIL treated [DOI] 10.18632/oncotarget.27799 PMC 바로가기 [Article Type] Priority Research Paper
Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and controlSARS-CoV-2의 전파 역학에서 슈퍼전파 사건: 개입 및 통제의 기회Essay Published on 2020-11-122022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] acute respiratory syndrome coronavirus basic reproduction number can not Care coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic cruise ships disease empirical evidence Essay etiological agent event Evidence feature globe individuals infecting Influenza influenza) Intervention killing less long tail Long-term care occurred onward transmission opportunity outbreak pandemic Pathogens plants Prevalence recommendation respiratory SARS-CoV-2 Secondary infection secondary infections Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread superspreading event superspreading events targeted intervention targeted interventions Transmissibility Transmission Transmission dynamics virus [DOI] 10.1371/journal.pbio.3000897 PMC 바로가기 [Article Type] Essay
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibitionArticle Published on 2020-10-292022-10-06 Journal: Blood [Category] SARS, 진단, [키워드] activate Activation acute respiratory syndrome Alternative pathway animal antibody APC Atypical blocked C3c catastrophic cells clinical manifestation complement Complement pathway contagious coronavirus COVID-19 Direct disease end-organ end-organ damage endothelial damage Evidence explain Human Hypothesis in vitro inactivation Injury killing mechanism mice mitigate Myocardial infarction Prevent renal respiratory virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins Spike protein stroke subunit supernatant syndrome target cells the N protein the SARS-CoV-2 thrombosis Trigger upstream uremic syndrome [DOI] 10.1182/blood.2020008248 PMC 바로가기 [Article Type] Article