New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral TargetsReview Published on 2020-10-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] antiviral therapies biological function candidate caused Contact coronavirus COVID-19 Critical disease disease pathogenesis ectasomes effective strategy Evidence Exosomes Extracellular extracellular vehicles extracellular vesicle facilitate functional generate highlight implication Infection insight Interaction lncRNA membrane-bound miRNA Mobility molecular multicellular organisms New non-coding RNA Novel coronavirus potential therapeutic target promote provide recent Research RNA SARS-CoV SARS-CoV-2 secreted Support target viral pathogenicity virus virus propagation [DOI] 10.3390/pathogens9110876 PMC 바로가기 [Article Type] Review
SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach인간 숙주 세포 noncoding-RNA 기계와 SARS-CoV 감염 누화: 인-실리코 접근Article Published on 2020-10-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] antiviral defense mechanism antiviral drug antiviral drugs approach Bioinformatics analysis caused Cell computational analysis coronavirus CoV infection COVID-19 defense mechanisms defined develop drug Efficacy engage Gene Expression Genome globe host cells human disease human host human host cell human host cells humans in-silico Infection Interaction investigated involved lncRNA Long MicroRNAs miRNA miRNAs mortality rate noncoding RNA Noncoding RNA, miRNA, lncRNA Noncoding RNAs Novel coronavirus outbreak Pathogenesis pathway Pathways post-transcriptionally potential therapeutic targets Proteins public health regulate Regulatory RNA SARS-CoV SARS-CoV infection shown signaling pathway TGF-beta TGF-beta signaling therapy transcribed transcript transcripts translated Vaccine virus [DOI] 10.1016/j.biopha.2020.110548 PMC 바로가기 [Article Type] Article
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article
Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infectionResearch Article Published on 2019-11-042022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] acting Acute inflammation Analysis binding biological process Cell cell line differentially expressed element epithelial expression of gene gastroenteritis Genes identification Infection Inflammation inflammation response inflammatory process Inflammatory response intestinal intestinal epithelial cell involved leukemia lncRNA lncRNA binding proteins lncRNAs Long long non-coding RNA Messenger RNA microRNA miRNA miRNAs mRNAs Necrosis Next-generation sequencing NGS NLRs NOD-like receptor noncoding RNA p65 Pathways Phosphorylation PML profile Protein Proteins reduction Result RIG-I-like receptor RLRs TGEV TLRs TNF Toll-like receptor transcription factor transmissible gastroenteritis virus virus infection was used [DOI] 10.1186/s12864-019-6156-5 PMC 바로가기 [Article Type] Research Article
Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cellsResearch Article Published on 2019-07-082022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Actin activate activated Analysis Antigen binding block Cell cellular change DCs dendritic cell dendritic cells disease-causing down-regulated ENhance explain functional Gene Expression Gene ontology Host IBV immune immune function inactivated indicated induce Infection Infectious Bronchitis Virus innate response Interaction leukocyte lncRNA long non-coding RNA Lymphocytes MAPK maturation mechanism Microarray microRNA miRNA miRNAs mRNA mRNAs neutralising non-coding RNA oxidative phosphorylation pathogenic mechanism pathway Pathway analysis performed presenting Protein provide recent regulate Research respond responsible Result significantly suggested supplementary material T cells target gene transcription factor transendothelial migration up-regulated viruses [DOI] 10.1186/s12864-019-5940-6 PMC 바로가기 [Article Type] Research Article
Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infectionResearch Article Published on 2019-04-112022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Antiviral strategies Biomarkers cause characterized contagious coronavirus Degradation diarrhea differentially expressed expression data facilitate functional enrichment Glycolysis High throughput sequencing histidine identifying Infection infection process Infectious disease Interaction Interaction network intestinal intestinal wall investigated involved late stage lncRNA long non-coding RNA Long non-coding RNA (lncRNA) metabolism miRNAs mRNA Necrosis Neonatal pathway Porcine deltacoronavirus Porcine deltacoronavirus infection qRT-PCR validation reported Research Result Sequencing significant effect small intestine Stage supplementary material villus viral replication virulence vomiting [DOI] 10.1186/s12917-019-1862-4 PMC 바로가기 [Article Type] Research Article
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs살모넬라 감염 시 핵 RNA 분해 감소는 항균 비암호화 RNA를 상향 조절한다.Article Published on 2018-07-022024-08-22 Journal: The EMBO Journal [Category] 살모넬라증, [키워드] innate immune response lncRNA nuclear exosome. nuclear RNA degradation Salmonella infection
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy게놈 전체 관련 연구에서 lncRna가 나병의 병리학적 염증 반응에 대한 위험 인자로 확인됨Research Article Published on 2017-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] 95% CI Affect Analysis association Brazil chromosome clinically Combined dataset disease eQTL etiologies evaluated Evidence evidence of example excessive inflammatory response experimental evidence Factor Genetic genetic control genetic factors Genetic variant Genome Genome-wide association study genomic GWAS GWAS meta-analysis Host IBD identify independent Inflammatory bowel disease inflammatory disorders Inflammatory response initial leprosy lncRNA loci locus mechanism nerve nerve damage occur offspring overlap Patient peripheral nerve reaction Reactions replicated Replication responses risk risk factor Risk factors separated SNP SNPs Support susceptibility undergo [DOI] 10.1371/journal.pgen.1006637 PMC 바로가기 [Article Type] Research Article
Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infectionResearch Paper Published on 2016-11-152023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] expression profile HBV infection Hepatocellular carcinoma lncRNA male [DOI] 10.18632/oncotarget.12732 PMC 바로가기 [Article Type] Research Paper
Comprehensive analysis of long non-coding RNA expression profiles in hepatitis B virus-related hepatocellular carcinomaResearch Paper Published on 2016-07-052023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] expression profile Hepatitis B virus Hepatocellular carcinoma lncRNA [DOI] 10.18632/oncotarget.9880 PMC 바로가기 [Article Type] Research Paper