Comparison Between China and Brazil in the Two Waves of COVID-19 Prevention and ControlCOVID-19 예방 및 통제의 두 가지 물결에서 중국과 브라질의 비교Article Published on 2022-06-012022-09-11 Journal: Journal of Epidemiology and Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] Brazil China conditions confirmed case confirmed cases Containment Containment measure Containment strategy Control cooperation country COVID-19 COVID-19 case COVID-19 cases cumulative cumulative death rate death case death rate effective Effectiveness Epidemic evaluate Factors Fighting indicate Intervention long-lasting measure Meteorological factor Mitigation Mitigation strategy much higher Multiple mutant strain Mutant strains National Perspective Policy Policy evaluation. premise prevention Prevention and control provide reached situation spread of COVID-19 the epidemic vaccination Wave [DOI] 10.1007/s44197-022-00036-6 PMC 바로가기 [Article Type] Article
Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study코로나 이후 증상 치료를 위한 관점 식품 보충제로서의 발효 카리카 파파야 및 모린다 시트리폴리아: 무작위 위약 대조 임상 실험실 연구Randomized Controlled Trial Published on 2022-05-252022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] added addition alleviate Anti-inflammatory effects antioxidant antioxidant activity ATP Carica papaya clinical clinical laboratory clinical symptom Clinical symptoms computer tomography COVID-19 disease cytokine Cytokines delta variant disease Electrocardiography expression fermented food supplements food IL-17A IL-6 IL-8 immune Laboratory leukocyte long-lasting mechanisms metabolite microbiota Moderate COVID-19 modulating Morinda citrifolia Nitrate nitrates nitrates/nitrites nitric oxide nitrite nitrites omicron oral-nasal-pharyngeal microbiota participant Patient per day performed phagocyte phagocytosis physical physical endurance placebo group placebo-controlled polymorphonuclear leukocyte post-COVID symptoms pro-inflammatory cytokines questionnaire Randomized significantly single-center Symptoms the placebo group Treatment protocol tropical variant virus were assessed [DOI] 10.3390/nu14112203 PMC 바로가기 [Article Type] Randomized Controlled Trial
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants재조합 RBD 백신의 비강내 투여는 오미크론이 포함된 SARS-CoV-2 변이체에 대한 장기 면역을 유도합니다Article Published on 2022-05-172022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration booster Cell coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 deficiency demonstrated Economy effective vaccine Emergency global health Health IgG antibody immune response immune responses Immunity immunization induce intramuscularly intranasal Local long-lasting lung lymph nodes memory T cell memory T cells mice Migration mucosal mutant strain Neutralizing omicron Omicron variants outbreak persistence proliferation protective immunity RBD required respiratory robust SARS-CoV-2 SARS-CoV-2 variant secretory IgA sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Strong suggested systemically T cells T-cell threat Vaccine vaccine candidate Vaccines variant variants waning immunity wild-type [DOI] 10.1038/s41392-022-01002-1 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease스파이크 및 뉴클레오캡시드 단백질을 발현하는 재조합 ACAM2000 백시니아 바이러스를 사용한 단일 면역은 SARS-CoV-2 유발 임상 질병으로부터 햄스터를 보호합니다Article Published on 2022-05-112022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] ACAM2000 Antibody titer Antigen antigens Breakthrough infection candidate clinical Combination competent Continuous COVID-19 COVID-19 vaccine COVID-19 vaccines deleted demonstrated described develop E3L Efficacy ENhance expected expressed expressing hamster hamsters highlight host range human cells immune responses Immunity immunization immunogenic Increasing induce Infection initial innate immune responses intramuscular investigated K3L long-lasting lymphocyte N protein Neutralizing antibody titer neutrophil Neutrophil-to-lymphocyte ratio nucleocapsid nucleocapsid antigen nucleocapsid antigens nucleocapsid protein Nucleocapsid proteins ortholog platform poxvirus Protective Protein recombinant recombinant COVID-19 vaccine Recovery time reduced reduced viral loads replaced SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants shorter recovery time shown significantly spike spike and nucleocapsid proteins the SARS-CoV-2 the Spike the vaccine Vaccine vaccine candidate vaccinia vaccinia virus variants Viral virus virus replication weight loss were expressed [DOI] 10.1128/jvi.00389-22 PMC 바로가기 [Article Type] Article
Multisensory mental representation in covid-19 patients and the possibility of long-lasting gustatory and olfactory dysfunction in the CNS코로나19 환자의 다감각적 정신 표현과 CNS에서 오래 지속되는 미각 및 후각 기능 장애의 가능성Article Published on 2022-05-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] activate Alter Brain cause chemosensory CNS COVID-19 COVID-19 adult patient COVID-19 infection COVID-19 negative COVID-19 patient COVID-19 patients dysfunction dysgeusia Gustatory Hyposmia Italian long-lasting Mental mental image neurological manifestation odor olfactory olfactory dysfunction Patient Psychological reduced reported responsible significantly significantly lower status [DOI] 10.1038/s41598-022-11119-6 PMC 바로가기 [Article Type] Article
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review
Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection단일 용량 복제 폭스바이러스 벡터 기반 RBD 백신은 SARS-CoV-2 감염에 대한 강력한 체액 및 T 세포 면역 반응을 유도합니다.Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration animal models Antigen approach breath complementary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cynomolgus macaques Dose escalation Efficacy evaluate the effect Express humoral immune immune response immune responses immunogenicity induce long-lasting mice Neutralizing antibodies outbreak pandemic poxvirus protective immunity RBD Receptor binding domain Replication respiratory response robust Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single dose Single-dose Support T cell T cell responses temperature Vaccine vaccine candidate vaccine platform Vaccines vaccinia virus vector [DOI] 10.1016/j.ymthe.2021.10.008 PMC 바로가기 [Article Type] Clinical Trial
Recombinant subunits of SARS-CoV-2 spike protein as vaccine candidates to elicit neutralizing antibodies중화 항체를 유도하기 위한 백신 후보로서의 SARS-CoV-2 스파이크 단백질의 재조합 소단위Article Published on 2022-05-012022-09-12 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody anti-spike antibody antibody Antibody titer checked Combination COVID-19 COVID-19 patient Critical effective Efficiency elicit evaluated fusion peptide in silico in vitro in vivo experiments Infection injected injection Live virus long-lasting mice neutralization neutralize Neutralizing neutralizing antibody neutralizing antibody responses produced Protein Proteins RBD recombinant Recombinant protein recombinant proteins reported robust S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus serum serum samples shown Spike protein stimulate subunit Subunit vaccine target the SARS-CoV-2 vaccination against COVID-19 Vaccine vaccine candidate Vaccine design VNT was increased were measured were used [DOI] 10.1002/jcla.24328 PMC 바로가기 [Article Type] Article
A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article