BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-ReactivityBCEPS: 향상된 면역원성과 교차 반응성으로 선형 B 세포 에피토프를 예측하는 웹 서버Article Published on 2021-10-142022-09-11 Journal: Cells [Category] MERS, SARS, 치료기술, 치료제, [키워드] Accessibility Accuracy antibody antigen-specific antibody antigens B cell epitope B cell epitopes B cells best conformational cross-reactive antibodies cross-reactive antibody dataset detect ectodomain ectodomains enhanced epitope Epitopes flexibility hydrophilicity identify IEDB Immune Epitope Database immunogenic immunogenicity independent linear linear B machine learning machine learning model membrane protein Membrane proteins MHC II molecules N-glycosylation site Neutralizing antibodies peptide-based vaccines predicted prediction Protein protein structures reached retrieved SARS-CoV-2 SARS-CoV-2 spike protein server specific antibodies spike Spike protein structures Support support vector machine the SARS-CoV-2 Web web server [DOI] 10.3390/cells10102744 PMC 바로가기 [Article Type] Article
Long-Term SARS-CoV-2 Specific Immunity Is Affected by the Severity of Initial COVID-19 and Patient AgeArticle Published on 2021-10-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affecting age caused Cohort convalescent coronavirus coronavirus disease COVID-19 COVID-19 severity demonstrated effective Factor humoral immune response Humoral immunity immune response Immunity immunosuppressed patient initial management membrane protein memory response pandemic Patient patients persistence Protein SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity severity Specific spike Spike protein T cell T cell responses virus virus-neutralizing antibodies was determined [DOI] 10.3390/jcm10194606 PMC 바로가기 [Article Type] Article
The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathwaysCandida glabrata UPC2A 전사 인자는 항진균제 약물 내성 경로의 글로벌 조절 인자입니다.Research Article Published on 2021-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition analogy antifungal drug resistance approach approaches ATP-binding cassette transporter azole azole drug azole drugs binding binding site Biosynthesis biosynthetic biosynthetic pathway Candida caspofungin Cdr1 component components compounds defined demonstrated described drug drug treatment drugs enzyme Enzymes ERG ergosterol Evidence expression expression of gene fluconazole form Frequency functional gene encoding Genes genes encoding genomic Impact induce interfere intrinsic involved lead Lipid lipids master regulator membrane membrane protein Membrane proteins membrane transporter membranes modulate mutant Mutation network overlap overproduction pathogenic yeast pathway Perspective producing Protein protein-encoding gene Proteins regulate regulated Regulatory regulatory network required resistant mutant Saccharomyces cerevisiae Sterol susceptibility synthesis target target gene Target genes targets therapy transcription factor transcriptional Transcriptomic analyses transcriptomic analysis translational Transport Treatment wild-type [DOI] 10.1371/journal.pgen.1009582 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19Article Published on 2021-09-292022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Anti-viral Antibody Response antigenicity binding compose coronavirus D614 variant develop Effectiveness elevated elicit elicited evaluated exhibited host cell host immune system Humoral response immune immune response immunogenic potential immunology Infection insertion Like M protein membrane membrane protein moderate N-glycosylation pandemic patients with COVID-19 patients with SARS-CoV-2 post-translational modification powerful tool Proteins reduced responses SARS-CoV-2 SARS-CoV-2 variant Scientific community serological response severe disease Severe patient transmembrane protein unique Vaccine Viral protein Virology with COVID-19 [DOI] 10.1016/j.isci.2021.103185 PMC 바로가기 [Article Type] Article
Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silicoShort Communications Published on 2021-09-202022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome analysed Analysing coronavirus function globe in silico Interaction less M protein membrane protein mutant Mutation N protein N-M protein interactions nucleocapsid protein predicted Protein proteomics reported Research Salt Bridge SARS-CoV-2 SARS-CoV-2 nucleocapsid sensitivity significant difference supplementary material temperature the SARS-CoV-2 variant virion wild type [DOI] 10.1186/s43141-021-00233-z PMC 바로가기 [Article Type] Short Communications
The SARS-CoV-2 spike protein is vulnerable to moderate electric fieldsArticle Published on 2021-09-132022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor B.1.1.7 B.1.351 bind binding biochemical Brazil Cell change Computational biophysics conformational change COVID-19 develop docking exhibit help high affinity host cell host receptor IMPROVE In-vitro Infection prevention long-lasting magnitude MD simulation membrane protein moderate MOST mutant Mutation observé occur P.1 physical Physical sciences Prevent Probability Protein Proteins RBD RBM receptor Receptor binding domain receptor binding motif required responsible SARS-CoV-2 SARS-CoV-2 spike protein South Africa spike structural flexibility tested the RBD the S protein the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein therapy undergo Vaccine variants of concern viral infectivity virus virus entry VoC [DOI] 10.1038/s41467-021-25478-7 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVAArticle Published on 2021-09-012022-10-27 Journal: African Journal of Infectious Diseases [Category] COVID-19, [키워드] Sausseria lappa administration animal model Cellular immune response cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immunomodulator Indonesia lung marker material membrane protein mice Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivityResearch Article Published on 2021-08-212023-06-15 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 COVID-19, Coronavirus disease 2019 DMEM, Dulbecco's modified Eagle's medium ERGIC, ER-Golgi intermediate compartment FBS, fetal bovine serum in vitro reconstitution Infectious disease membrane enzyme membrane protein posttranslational modification (PTM) protein palmitoylation PTM, posttranslational modification SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Spike protein Viral protein zDHHC enzyme [DOI] 10.1016/j.jbc.2021.101112 PMC 바로가기 [Article Type] Research Article
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes동종 세포주 내 ACE2 단백질 발현은 이질적이며 별개의 전사체와 연관됩니다.Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 ACE2 expression ACE2 gene ACE2 protein angiotensin angiotensin-converting enzyme 2 antibodies application approach Cell cell line cells cellular cellular receptor daughter cells detectable enrichment enzyme Epigenetic expression fixed Gene regulation heterogeneity heterogeneous HUH7 cells identify initiated membrane protein Membrane proteins mRNA abundance mRNA level multiple cell line multiple cell lines pathway promoter protein level proximal Regulation Renin renin-angiotensin system RNA-Seq SARS-CoV-2 SARS-CoV-2 virus single cells specificity subset Support the SARS-CoV-2 virus transcript transcription factor Transcriptome transcriptomes transcripts [DOI] 10.1038/s41598-021-95308-9 PMC 바로가기 [Article Type] Article