Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations선택적 식물의 파이토케미컬은 SARS-CoV-2에 대한 유망한 잠재력을 가지고 있습니다: 분자 도킹, MD 시뮬레이션 및 양자 계산을 통한 조사 및 확증Research Article Published on 2020-10-132022-09-10 Journal: BioMed Research International [Category] 치료제, [키워드] acute respiratory syndrome Analysis analyzed association Beta Beta coronaviruses binding binding affinity Care caused Compound compounds Coronaviridae Coronavirus-2 docked glycoside Helicase in viral in vitro in vivo Infection inhibitor investigation MERS methyltransferase Middle East Middle East respiratory syndrome molecular molecular dynamics molecular dynamics simulations Nidovirale Nidovirales nonstructural protein nonstructural proteins nsp13 pandemic Pathogenesis performed pharmacological phytochemical plant positive Potential Protein protocols quantum reactivity reported respiratory Rhamnetin Ribonucleic acid SARS-CoV-2 screened Sesquiterpene Severe acute respiratory syndrome single-stranded subject syndrome these compound these compounds these viruses treat Vaccine Viral viral pathogenesis virus viruses Wuhan Wuhan, China [DOI] 10.1155/2020/6237160 PMC 바로가기 [Article Type] Research Article
Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum ComputationsResearch Article Published on 2020-10-132022-10-27 Journal: BioMed Research International [Category] [키워드] acute respiratory syndrome Analysis analyzed association Beta coronaviruses binding binding affinity Care caused Compound compounds Coronaviridae Coronavirus-2 docked glycoside Helicase in viral in vitro in vivo Infection inhibitor investigation MERS methyltransferase Middle East molecular Nidovirale nonstructural protein nsp13 pandemic Pathogenesis performed pharmacological phytochemical plant positive Potential Protein protocols quantum reactivity reported Rhamnetin SARS-CoV-2 screened Sesquiterpene single-stranded subject syndrome these compound treat Vaccine virus viruses Wuhan, China [DOI] 10.1155/2020/6237160 PMC 바로가기 [Article Type] Research Article
Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum ComputationsResearch Article Published on 2020-10-132022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis analyzed association Beta coronaviruses binding binding affinity Care caused Compound compounds Coronaviridae Coronavirus-2 docked glycoside Helicase in viral in vitro in vivo Infection inhibitor investigation MERS methyltransferase Middle East molecular Nidovirale nonstructural protein nsp13 pandemic Pathogenesis performed pharmacological phytochemical plant positive Potential Protein protocols quantum reactivity reported Rhamnetin SARS-CoV-2 screened Sesquiterpene single-stranded subject syndrome these compound treat Vaccine virus viruses Wuhan, China [DOI] 10.1155/2020/6237160 PMC 바로가기 [Article Type] Research Article
Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2′-O-ribose methyltransferase of SARS-CoV-2 coronavirusResearch Article Published on 2020-10-042023-07-01 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, [키워드] inhibitor KDKE motif methyltransferase Molecular dynamics simulation nsp16 SARS-CoV-2 Virtual screening [DOI] 10.1080/07391102.2020.1828172 PMC 바로가기 [Article Type] Research Article
Structural insight into the recognition of S -adenosyl-L-homocysteine and sinefungin in SARS-CoV-2 Nsp16/Nsp10 RNA cap 2′-O-MethyltransferaseResearch Article Published on 2020-10-012022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract acute respiratory syndrome antiviral drug approaches atomic binding binding affinity binding mechanism caused Cell clinically complex coronavirus coronavirus disease COVID-19 effective enzyme Free energy calculation group H-bond inhibitor Innate immunity MD simulations mechanisms methyltransferase mimicking molecular Molecular dynamics simulation non-structural protein Nsp16/nsp10 Nsps nucleoside analog pandemic Rational drug design residue residues RNA SARS-CoV-2 Spread the SARS-CoV-2 transfer Vaccine virus detection [DOI] 10.1016/j.csbj.2020.09.032 PMC 바로가기 [Article Type] Research Article
Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Reveals Mosaic Pattern of Phylogeographical DistributionResearch Article Published on 2020-07-282022-10-29 Journal: mSystems [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect age factor Amino acid Analysis analyzed binding caused circulating claimed Comparative Complete coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patients COVID-2019 evade Frame GenBank accession Genome genomic geographical region global pandemic Health health condition Host Human human receptors IL-8 impacted IMPROVE Infection interact Interaction interferon involved less methyltransferase mosaic mRNA mutant mutant proteins NKRF nonsynonymous mutation novel SARS-CoV-2 virus nsp13 nsp14 Nsp15 ORF1b outbreak pattern Pneumonia polyproteins Population Protein Replication replicative required residue RNA S-protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain severity signaling pathway Single nucleotide polymorphism SNPs Spread stability Structural analysis the disease the interferon the United State The United States Transmission transmission rates Travel unique viral isolate Viral protein viral replication viral variant virus viruses wild-type Wuhan, China [DOI] 10.1128/mSystems.00505-20 PMC 바로가기 [Article Type] Research Article
Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefunginArticle Published on 2020-07-242022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] acute respiratory syndrome Analysis Antiviral agents antiviral therapy catalytic site cofactor comparison complex coronavirus COVID-19 pandemic Drug discovery enzyme expresse feasible information inhibitor involved methyltransferase Protein RNA RNA methyltransferase SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses stability the SARS-CoV-2 therapy These data Viral RNA virus X-ray crystallography Zika [DOI] 10.1038/s41467-020-17495-9 PMC 바로가기 [Article Type] Article
Oral Methioninase for Covid-19 Methionine-restriction TherapyResearch Article Published on 2020-05-032023-07-02 Journal: In vivo (Athens, Greece) [Category] SARS, [키워드] coronavirus COVID-19 methioninase methionine restriction Methylation methyltransferase RNA genome S-adenosylmethionine SARS-CoV-2 [DOI] 10.21873/invivo.11948 PMC 바로가기 [Article Type] Research Article
Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathwayArticle Published on 2019-12-012023-06-12 Journal: Journal of microbiology (Seoul, Korea) [Category] E형 간염, [키워드] hepatitis E virus interferon methyltransferase [DOI] 10.1007/s12275-019-9478-8 PMC 바로가기
Dose-Dependent Inhibition of Melanoma Differentiation-Associated Gene 5-Mediated Activation of Type I Interferon Responses by Methyltransferase of Hepatitis E VirusArticle Published on 2019-07-282023-06-12 Journal: The Cochrane database of systematic reviews [Category] E형 간염, [키워드] hepatitis E virus interferon beta methyltransferase [DOI] 10.4014/jmb.1905.05040