Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Research Published on 2021-09-302022-10-05 Journal: Nature methods [Category] SARS, 유전자 메커니즘, 임상, [키워드] activity Analyzer Anti-inflammatory BMP6 Cancer cascade cell population chemokine chronic inflammation collected Critical CXCL8 cytokine cytokine signaling Cytokines database disease Diseases functions growth factor half-live Health human inflammatory diseases Intercellular communication modulated Predictive remained responses severe coronavirus disease Signaling single-cell single-cell level target gene therapeutic target tissue transcriptional transcriptome profile transcriptomic data transcriptomic profiles [DOI] 10.1038/s41592-021-01274-5 [Article Type] Research
Immunobiotic Lactobacilli Improve Resistance of Respiratory Epithelial Cells to SARS-CoV-2 InfectionArticle Published on 2021-09-152022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation acute respiratory syndrome Administered animal model Antiviral Calu-3 cell calu-3 cells carried CCL5 coronavirus COVID-19 CXCL10 production CXCL8 DDX58 Effect expression identify IFN-β IFNAR2 IL-6 immune response immunobiotics immunomodulatory immunomodulatory effect in vivo experiment Infection Influenza virus innate immune response knowledge Lactiplantibacillus plantarum lung mice modify modulated New coronavirus OAS1 outcome Probiotics reduce regulated Replication reported resistance respiratory respiratory epithelial cell respiratory epithelial cells Respiratory pathogens respiratory syncytial virus SARS-CoV-2 SARS-COV-2 infection stimulated strain susceptibility TLR3 Toll-like receptor 3 Treatment viral pathogens [DOI] 10.3390/pathogens10091197 PMC 바로가기 [Article Type] Article
Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19Article Published on 2021-09-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome ADAM17 analyzed androgen androgens angiotensin converting enzyme 2 cardiac cardiometabolic cathepsin L caused complications conditions coronavirus coronavirus disease COVID-19 Deleterious Dihydrotestosterone disorder Endocrine exacerbated expression fat Fat mass female furin high risk increase in kidney LFD mice mitigate Modification modulated mRNA expression obesity outcome Ovary Polycystic polycystic ovary Polycystic ovary syndrome positively correlated Protein protein expression receptor renal SARS-CoV-2 SARS-CoV-2 viral serum severity susceptibility syndrome TMPRSS2 TMPRSS4 treated Treatment upregulated weight loss women [DOI] 10.3390/ijms22189746 PMC 바로가기 [Article Type] Article
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trialCOVID-19를 가진 입원 환자를위한 회복기 혈장 : 개방형, 무작위 대조 시험Randomized Controlled Trial Published on 2021-09-092022-08-13 Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 임상, 진단, 치료법, 치료제, [키워드] 95% CI 95% confidence interval Analysis antibody Antibody therapy antibody-dependent cellular cytotoxicity benefit Clinical outcome clinical outcomes conducted Controlled trial convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical death did not reduce Donor Efficacy Enrollment Exploratory analyses futility had more hospitalized patient hospitalized patients IgG increase in intention-to-treat analysis intubation Logistic regression meeting modulated Multivariate analysis NCT04348656 neutralization occurred Odds ratio Open-label outcomes oxygen Patient patients hospitalized plasma Primary outcome profile Randomized Randomized controlled trial randomized trial receiving reduced Relative risk respiratory respiratory symptom risk Serious Adverse Event shown significantly Spike protein standard care Standard of care standardized log Subgroup analyses suggested therapeutic effect transfusion transmembrane spike protein Trial uncontrolled studies uncontrolled study with COVID-19 [DOI] 10.1038/s41591-021-01488-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Anti-COVID-19 Vaccination in Patients with Autoimmune-Autoinflammatory Disorders and Primary/Secondary Immunodeficiencies: The Position of the Task Force on Behalf of the Italian Immunological SocietiesReview Published on 2021-09-042022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ad-hoc Administered auto-immune auto-inflammatory disorders brand chronic infection clinical condition Consequences contraindication Coronavirus disease 2019 country COVID-19 COVID-19 vaccine COVID-19 vaccines develop disease disorder eligible facilitate force Health highest immune systems immunosuppressive Infection Italian Italy modulated mRNA vaccine pandemic Patient patients PIDs position Primary immunodeficiencies respond SARS-CoV-2 secondary immunodeficiencies sequence Society suffered therapy vaccination Vaccine Vaccines viral spread Viral variants [DOI] 10.3390/biomedicines9091163 PMC 바로가기 [Article Type] Review
Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groupsResearch Article Published on 2021-09-022022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Acidic acidic pH Alter calculated calculation characterisation conformations Coronaviruses Cryo-electron microscopy Effect form group histidine insertion Mild modulated Neutral pH-dependence pre-fusion predicted protein electrostatics RBD Receptor binding Receptor binding domain reduce residues SARS-CoV-2 SARS-CoV-2 spike protein Spike protein spike trimer spike trimers stability Structure the SARS-CoV-2 transition trimer Trimers Vaccine design variant [DOI] 10.1016/j.csbj.2021.08.049 PMC 바로가기 [Article Type] Research Article
Inferring the Main Drivers of SARS‐CoV‐2 Global Transmissibility by Feature Selection MethodsThe COVID‐19 pandemic: linking health, society and environment Published on 2021-09-012022-11-01 Journal: GeoHealth [Category] COVID-19, [키워드] absence Affect Analysis approach basic reproduction number BCG vaccination component Contact country Coverage COVID‐19 COVID‐19 environmental dependence determinants disease spread risk factors Diseases driver environmental factor Factor Feature selection Frequency GDP high correlation Human Development Index identify identifying Infection infection risks Interpretation machine Migration modulated naïve Other Point Prevalence principal principal component analysis regression analysis SARS‐CoV‐2 Selection significantly social distancing Spread suggested susceptible Transmissibility variable while [DOI] 10.1029/2021GH000432 PMC 바로가기 [Article Type] The COVID‐19 pandemic: linking health, society and environment
Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell linesResearch article Published on 2021-09-012022-10-05 Journal: Life sciences [Category] 신약개발, [키워드] ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome calu-3 cells Cell cell line cleavage Clinical treatment Combination coronavirus disease downregulate Effect Emetine enzyme expression flow cytometry human lung human lung cells hydrogen peroxide Infection inhibitor inhibitors knockdown knocked down modulated NAC NF-kappa B NF-κB NF-κB signaling P50 PARP protein expression protein levels pyrrolidine dithiocarbamate reactive oxygen specy receptor reduced renin-angiotensin system reversed ROS RT-qPCR SARS-CoV-2 Significance siRNA suppressed surface Treatment Triclabendazole utility was increased were measured western blotting Zinc zinc supplementation [DOI] 10.1016/j.lfs.2021.119752 [Article Type] Research article
β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approachArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] β-carboline ADP-ribose ADP-ribosylation analogue anti-SARS-CoV-2 approach binding affinity binding free energy bioinformatics candidate computational approach coronavirus creating database demonstrated docking docking score drug design Glide GS-441524 Host immune response implicated indicated induce Infection Ligand ligands low expression macrodomain macromolecule metabolite modulated Molecular dynamics simulation Nsp3 nsp3 macrodomain parameter Pathogenesis plasticity predicted receptor Remdesivir reported SARS-CoV-2 screened selected small molecule stability the SARS-CoV-2 Toxicity viral replication [DOI] 10.3906/biy-2106-64 PMC 바로가기 [Article Type] Article
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDSArticle Published on 2021-08-262022-10-04 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] Acute inflammation acute respiratory distress Analysis ARDS candidate drug cause causes characterized colony stimulating factor Control COVID-19 Critically ill patient Dexamethasone dysregulated elevated etiologies expression expression of gene feature Gene Expression granulocyte host gene expression host response identify Immunity immunological Inflammation interferon-stimulated gene ISG lower airway Lower respiratory tract mechanical ventilation Mild modulate modulated Molecular medicine observé Patient patients with COVID-19 predicted proinflammatory gene PTEN reduced reveal RNA sequencing SARS-CoV-2 SARS-CoV-2 viral load Signaling syndrome tracheal tracheal aspirate transcriptional Translational research viral infection Viral pneumonia [DOI] 10.1038/s41467-021-25040-5 PMC 바로가기 [Article Type] Article