Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis항진균제 감수성Online Only Articles Published on 2021-10-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] AIDS Amphotericin Antifungal Antifungal treatment clearance clinical isolates cryptococcal meningitis fluconazole flucytosine fungal HIV investigated isolate Meningitis monotherapy Mortality no correlation outcome Randomized controlled trial survival susceptibility susceptibility testing [DOI] 10.1093/cid/ciaa1544 PMC 바로가기 [Article Type] Online Only Articles
SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy항체 단독 요법을 받은 면역 저하 환자의 SARS-CoV-2 변이체Expedited Published on 2021-10-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bamlanivimab blood sample Blood samples compartmentalization coronavirus coronavirus disease Coronaviruses COVID-19 Evolution Immunocompromised Immunotherapy melting curve analysis monoclonal antibody monotherapy Mutation nasopharyngeal polymorphism populations Rapid Receptor binding domain respiratory respiratory infections SARS-CoV-2 Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-nucleotide Single-nucleotide polymorphisms Spike receptor binding domain variants Viral viral evolution viruses whole-genome sequencing zoonoses [DOI] 10.3201/eid2710.211509 PMC 바로가기 [Article Type] Expedited
Baricitinib plus dexamethasone compared to dexamethasone for the treatment of severe COVID-19 pneumonia: A retrospective analysisResearch article Published on 2021-10-012022-10-05 Journal: Journal of microbiology, immunology, and infection [Category] SARS, 치료법, [키워드] age analyzed Baricitinib bilateral pulmonary infiltrates both groups Clinical outcome collected COVID-19 criteria Dexamethasone for inclusion hospital hospitalized patient ICU admission IMV Infection infection rates infections Invasive mechanical ventilation male mechanical ventilation monotherapy Mortality no difference objective overall mortality Patient patients with COVID-19 performed Pneumonia progression required Result retrospective Retrospective analysis SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia significantly lower treated Treatment were assessed were excluded [DOI] 10.1016/j.jmii.2021.05.009 [Article Type] Research article
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19Medicine Published on 2021-09-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] anti-IL-6 receptor antibody basal chemokine Clinical characteristics Clinical deterioration Combination combination therapy Corticosteroid COVID-19 Critically ill Critically ill patient CRP cytokine Cytokine storm Dexamethasone Effect evaluated exhibited expression healthy controls humanized IFN-γ IgG IgG antibody IL-6 Ill increase in indicate Inflammatory inhibit inhibited IP-10 management MCP-1 mechanical ventilation Meta-analysis Methylprednisolone monotherapy multiplex numbers of patients observational study outcomes oxygen supply Patient patients treated patients with COVID-19 Pneumonia Ratio RCT reduction in remained required respond Retrospective study serum severe COVID-19 significant increase significantly higher systematic review Tocilizumab tocilizumab administration treat Treatment virus with COVID-19 worsening [DOI] 10.3389/fmed.2021.734838 PMC 바로가기 [Article Type] Medicine
Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with RemdesivirArticle Published on 2021-09-162022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] activity anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug biogenesis calpeptin calu-3 cells clinical study Combination coronavirus disease COVID-19 cysteine cytotoxicity demonstrated dose-dependent inhibition drug Effect EVs exhibited expression extracellular vesicle Extracellular vesicles half-maximal inhibitory concentration Health IC50 Impact infected cell inhibited inhibitor inhibitors monotherapy pandemic pathway proteinase release mechanism Remdesivir SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral replication screened Screening significantly small molecule inhibitor therapeutic efficacy validation Vero E6 cell VERO-E6 virion virus [DOI] 10.3390/biomedicines9091230 PMC 바로가기 [Article Type] Article
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy항-CD20 요법을 받고 있는 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신 접종 후 세포 및 체액 면역 반응Article Published on 2021-09-142022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] activated ameliorated anti-CD20 anti-CD20 therapy Anti-RBD IgG antibodies antibody Antigen antigen-specific antibody B cell BNT162b2 breath CD4 CD8 CD8 T cell CD8 T cell responses Cell circulating COVID-19 domain follicular generate Health policy healthy control healthy controls healthy individuals humans humoral immune response immune immune protection immune responses Immunosuppressed immunosuppressed patient immunosuppressed patients implication in healthy individual investigated memory B memory B cell memory B cells Messenger RNA monoclonal antibody monotherapy Most patients mRNA mRNA vaccination mRNA vaccine mRNA-1273 multiple sclerosis Patient patients priming public health Receptor-binding domain reduced response responses RNA vaccines robust SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody significantly skewed specific antibodies T cell T cell response T cell responses T cells the SARS-CoV-2 These data treated Treatment type 1 helper vaccination vaccine-induced immune response [DOI] 10.1038/s41591-021-01507-2 PMC 바로가기 [Article Type] Article
Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case ReportsSystematic Review Published on 2021-09-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration adverse events affected article Autoimmune average case reports Case series clinician Comorbidity coronavirus COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines disorder distribution dose eligible herpes zoster immunosuppressants individual mammary management monotherapy Patient patients Reactivation receiving report reported review rheumatoid arthritis Safe SARS-CoV-2 skin lesion Symptom systematic review Treatment valacyclovir varicella Varicella zoster virus virus while Zoster [DOI] 10.3390/vaccines9091013 PMC 바로가기 [Article Type] Systematic Review
Outpatient Management of COVID-19 With Monoclonal Antibody Therapy in a Young Renal Transplant PatientInternal Medicine Published on 2021-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] available data baseline Care complex coronavirus disease cough COVID-19 high mortality rate highlight Hospitalization ICU Immunocompromised patient Immunosuppression immunosuppressive increased risk infectious complication mAb male mild case monoclonal antibodies monoclonal antibody monotherapy Mortality Outpatient Patient positive receiving recipient regimen regimens renal Renal transplant significantly lower solid organ transplant symptomatic tested therapy Transplant treated [DOI] 10.7759/cureus.17672 PMC 바로가기 [Article Type] Internal Medicine
Bamlanivimab as monotherapy in two immunocompromised patients with COVID-192명의 면역저하 코로나19 환자에서 단독요법으로 밤라니비맙(Bamlanivimab)Article Published on 2021-09-012022-09-12 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 진단, [키워드] bamlanivimab Immunocompromised patient monotherapy with COVID-19 [DOI] 10.1016/S2666-5247(21)00189-0 PMC 바로가기 [Article Type] Article
Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2SARS-COV-2의 알파 변이체에 감염된 고위험 환자 중에서 Bamlanivimab 단일 요법 후 E484K 돌연변이의 출현Article Published on 2021-08-192022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] Administered administration authorization B.1.1.7 B.1.1.7 variant bamlanivimab baseline belatacept clinically Complication COVID-19 COVID-19 diagnosis COVID-19 patient died E484K emergence Emergency Emergency use authorization Europe FIVE France high risk High-risk patients infused infusion IV injection kidney transplant males management median age monoclonal antibodies monoclonal antibody monotherapy multiple comorbidities mutant Mutation nasopharyngeal nasopharyngeal viral nosocomial outcome Patient patients Prevent resistance risk RT-PCR SARS-CoV-2 SARS-COV-2 infection Sequencing severe COVID-19 single dose the United State treated Treatment United States variant variants Viral were infected whole genome Whole genome sequencing [DOI] 10.3390/v13081642 PMC 바로가기 [Article Type] Article