Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19COVID-19에서 잠재적인 바이오마커 및 치료 표적으로서의 골수 유래 억제 세포Review Published on 2021-06-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] activating adaptive Biomarker Biomarkers Cell clinical Clinical presentations COVID-19 COVID-19 infection COVID-19 pneumonia defined disease disease course disease severity driving dysregulated dysregulation Evidence Host immune response immune activation immune responses Immunity immunology impair innate immune cell lymphocyte lymphocyte counts MDSC mechanism mediators myeloid cell pathophysiology Patient Pneumonia Potential pro-inflammatory state promote recruitment resulting secretion severe COVID-19 shown Spectrum suppressor suppressor cells survival T-cell Response T-cell responses target therapeutic target therapeutic targets turn virus [DOI] 10.3389/fimmu.2021.697405 PMC 바로가기 [Article Type] Review
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitroResearch Article Published on 2021-06-162022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] Bacterial Bacterial sepsis Blood Bone marrow CD14 Cell cell subpopulation cells cellular clinical manifestation correlated COVID-19 CRISPR-Cas9 Culture cytokine cytokines IL-6 datasets demonstrated dysregulation expression Factor Gene Expression healthy IL-10 IL-6 immunosuppressive in vitro in vitro study induce monocyte MS1 myeloid myeloid cell neutrophil Patient plasma plasma concentration progenitor cell receptor reported RNA SARS-COV-2 infection Sepsis severe COVID-19 severe COVID-19 patient severe infections severity systemic cytokine transcriptomics Treatment up-regulated [DOI] 10.1126/scitranslmed.abe9599 PMC 바로가기 [Article Type] Research Article
Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology네트워크 약리학에 대한 체계적인 연구를 통해 2019 년 에모딘 처리 된 코로나 바이러스 질병의 치료 표적 및 분자 메커니즘을 드러냅니다.Research Paper Published on 2021-06-152022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 B-cell B-cell lymphoma Bacterial BCL2L1 bioinformatics Biomarker Biomarkers Cancer candidate gene CASP3 caspase caspase-3 colony stimulating factor complications coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CSF2 CXCL8 developmental Diabetic diabetic complications docking Effect EGFR emodin endothelial epidermal epidermal growth factor exhibited Factor GO analysis growth factor IL-17 IL1B Infection interleukin interleukin-8 involved KEGG leads lipopolysaccharide MAPK MAPK signaling MAPK1 MAPK14 MCL1 mitogen mitogen-activated protein kinase molecular molecular docking molecular mechanism molecular mechanisms molecule myeloid cell Necrosis network pharmacology pathway Pathways pertussis pharmacological pharmacological mechanism pharmacological target Protein protein kinase Proteoglycan proteoglycans PTGS2 RAGE receptor receptor signaling reproduction reproductive respiratory screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown signaling pathway suggested target targets therapeutic target TNF TNF signaling TP53 treating COVID-19 Treatment treatment of COVID-19 Tumor tumor necrosis tumor necrosis factor Vascular VEGFA [DOI] 10.18632/aging.203098 PMC 바로가기 [Article Type] Research Paper
AI-guided discovery of the invariant host response to viral pandemics바이러스 전염병에 대한 불변 숙주 반응의 AI 유도 발견Research Paper Published on 2021-06-112022-09-11 Journal: EBioMedicine [Category] MERS, 바이오마커, 진단, 치료제, [키워드] “cytokine storm” abrogate ACE2 acting analyzed Angiotensin converting enzyme (ACE)-2 Antiviral antiviral agent Apoptosis approach Artificial intelligence/machine learning Boolean equivalent clusters candidate drugs cause cell senescence center clinical conserved Cooperative Coronavirus COVID-19 coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dataset determine Diego disease severity EIDD-2801 elevated ENCODE entry of SARS-CoV-2 epithelial facilitate fatal COVID-19 fatal disease fatality finding Fund funding hamster Healthcare system High-dose host cells Host immune response host response Human IL15 IL15RA immune response immunologist implicated in viral Interleukin 15 (IL15) knowledge limit limits LJI lung Lung alveoli lung epithelial Lungs myeloid cell myeloid cells natural killer (NK) cells Neutralizing antibodies neutralizing antibody NIH NK cell office over Pandemics paradoxical Patient plasma Plasma levels President Program Quantitative receptor scientist signature STEM stem cell subset supported System therapeutic to define transcriptomic University of California utility Viral virus was used [DOI] 10.1016/j.ebiom.2021.103390 PMC 바로가기 [Article Type] Research Paper
Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 SignalingImmunology Published on 2021-05-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome Angiotensin-converting enzyme Anti-TNF-α anti-TNF-α Autoimmune disease blocking cellular entry coronavirus COVID-19 COVID-19 pandemic COVID19 Critical demonstrated downregulated downstream enzyme expression healthy control IL-6 Immunity increase Infection inflammatory condition investigated leukemia Macrophage macrophages mechanism modulation monoclonal antibody Mycobacterium myeloid cell Notch pandemic Patient patients plasma rheumatoid arthritis risk SARS-CoV-2 Signaling significantly lower Standard therapy susceptibility TACE therapy THP-1 transmembrane serine protease treated Treatment upregulated viability [DOI] 10.3389/fimmu.2021.641295 PMC 바로가기 [Article Type] Immunology
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation Research Published on 2021-04-122022-10-05 Journal: Nature metabolism [Category] 바이오마커, 신약개발, [키워드] Activation Anti-inflammatory anti-inflammatory action bind Biomarker block Cell circulating Colchicine disorders dose Efficacy and safety GDF15 growth hepatocyte hepatocytes identity in vivo indirect mechanism induce inflamed tissues Inflammatory inflammatory signalling inhibit liver mechanism mice molecular myeloid cell myeloid cells phosphatase positive PTPN6 receptor recruitment Regulation required reveal Safe secretion selective treat Trigger [DOI] 10.1038/s42255-021-00366-y [Article Type] Research
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airwayArticle Published on 2021-03-292022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료제, [키워드] absence Activation airway approach Blood carried Cell clearance Comprehensive comprehensive analysis Computational biology and bioinformatics contribute coronavirus COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patients disease pathogenesis driven by drugs Gene Expression gene expression profile host response identify Infection Inflammation Inflammatory Inflammatory mediators Innate immune cells lung myeloid cell pathogenesis of COVID-19 patients Population potential therapeutic target SARS-CoV2 therapy transcriptional transcriptomic transcriptomic analysis viral infection virus [DOI] 10.1038/s41598-021-86002-x PMC 바로가기 [Article Type] Article
COVID-19 and HIV-Associated Immune Reconstitution Inflammatory Syndrome: Emergence of Pathogen-Specific Immune Responses Adding Fuel to the FireImmunology Published on 2021-03-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] absence activating Activation Adaptive immune response Adding amplification amplified antibody Antibody Response antigens arise B cell CD4 Characteristics characterized chemokine condition coronavirus disease COVID-19 cytokine Effect effective emergence fire fuel HIV-1 infection human immunodeficiency virus type 1 hyperinflammation IgA2 IgG1 antibodies IgG3 immune immune reconstitution inflammatory syndrome immune response immunomodulatory immunomodulatory effect immunopathology Inflammatory innate immune response innate response Interleukin-18 Macrophage Monocytes mycobacterial myeloid cell Neutrophils pathogen-specific pathway Patient pro-inflammatory produced promoted proportion response SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 skewed syndrome T cell response T cells Th1 therapy [DOI] 10.3389/fimmu.2021.649567 PMC 바로가기 [Article Type] Immunology
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severityCOVID-19 중증도의 바이오마커로서 순환하는 골수 세포의 이종 NLRP3 인플라마좀 시그니처Article Published on 2021-03-092022-09-11 Journal: Blood advances [Category] SARS, 바이오마커, [키워드] Activation acute respiratory syndrome Biomarker Blood caspase caspase-1 CD66b Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patients dysregulated immune response eosinophil eosinophils Evolution granulocyte Granulocytes healthy donor healthy donors immature neutrophil immune response Infection Innate immunity key factor Mild monocyte Monocytes myeloid cell myeloid cells Neutrophils nigericin NLRP3 NLRP3 inflammasome outcome pathogen pathogen-associated molecular Patient predict proportion Registered respiratory restored severe acute respiratory syndrome Coronavirus Trial [DOI] 10.1182/bloodadvances.2020003918 PMC 바로가기 [Article Type] Article
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients대사 프로그램은 중증 COVID-19 환자의 역기능 면역 반응을 정의합니다Article Published on 2021-02-262022-09-12 Journal: Cell Reports [Category] MERS, SARS, 진단, [키워드] Abstract accompanied acute COVID-19 anion Apoptosis caspase Cell channel Characteristics coronavirus disease COVID-19 COVID-19 patient develop disease disease severity Elderly patient Express functional highlight identify Immune cell immune response immunological immunology immunometabolism increase in increases in Infection inhibited lymphopenia MDSCs metabolic metabolic pathway metabolism Mild Mitochondria mitochondrial mitochondrial dysfunction myeloid cell observé oligomerization Patient phenotype Population predict provide regimens SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patient severe disease T cell T cells therapeutic therapeutic target these cell Thompson unique VDAC1 viral infections [DOI] 10.1016/j.celrep.2021.108863 PMC 바로가기 [Article Type] Article