Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodiesACE2 및 2개의 강력한 중화 항체와 복합체를 이루는 N501Y SARS-CoV-2 스파이크 단백질의 저온 전자 현미경 구조Research Article Published on 2021-04-292022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, MERS, SARS, [키워드] ACE2 ACE2 receptor B.1.1.7 binding Cavity changes circulating complex contribute Cryo-electron microscopy cryo-EM cryo-EM structure cryo-EM structures ectodomain epitope Epitopes Interaction Microscopy mutant Mutation N501Y N501Y mutation neutralization neutralizing antibody provide Receptor binding domain reported retained SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Spike receptor binding domain strain Structure thought [DOI] 10.1371/journal.pbio.3001237 PMC 바로가기 [Article Type] Research Article
Report of SARS-CoV-2 B1.1.7 Lineage in MoroccoGenome Sequences Published on 2021-04-222022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome assigned B.1.1.7 lineage coronavirus female Genetic variation genome sequence Ion Morocco N501Y mutation Nasopharyngeal swab Patient report SARS-CoV-2 Sequencing was collected was done [DOI] 10.1128/MRA.00240-21 PMC 바로가기 [Article Type] Genome Sequences
The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 PseudovirusSARS-CoV-2 계통 B.1.351 슈도바이러스의 감염성 및 중화 효율에 미치는 영향Communication Published on 2021-04-072022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody B.1.351 Casirivimab D614G E484K E484K mutation E484K mutations Efficacy Efficiency Imdevimab Impact indicated Infectivity investigated K417N K417N and E484K mutation of spike Lineage monoclonal antibodies multiple mutation multiple mutations mutant Mutation N501Y N501Y mutation neutralization neutralized Neutralizing antibodies pseudovirus pseudoviruses raising RBD Receptor-binding domain referred to SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly increased South Africa Strains tested the receptor-binding domain Transmissibility variant of SARS-CoV-2 Viral viral infectivity viral spread Wuhan Wuhan strain [DOI] 10.3390/v13040633 PMC 바로가기 [Article Type] Communication
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variantsSARS-CoV-2 및 순환 변이체에 대한 mRNA 백신 유도 항체Article Published on 2021-04-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibody arising binding BNT162b2 Cell circulating variant Clinical efficacy Clinical use Cohort Donor E484K elicited epitope Epitopes expressing IgM and IgG individual injection K417N memory B memory B cell memory B cells Moderna monoclonal antibodies monoclonal antibody mRNA mRNA vaccine mRNA vaccines mRNA-1273 Mutation N501Y N501Y mutation natural infection neutralization neutralize Neutralizing activity Pfizer-BioNTech plasma RBD RBD-specific memory B cells receptor response SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein stomatitis tested the vaccine the vaccines titre Vaccine Vaccines variants vesicular stomatitis vesicular stomatitis virus Volunteer volunteers was reduced [DOI] 10.1038/s41586-021-03324-6 PMC 바로가기 [Article Type] Article
Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications새로운 SARS-CoV-2 변이체 B.1.1.7, B.1.351 및 B.1.1.28.1의 구조 기능 분석: 임상, 진단, 치료 및 공중 보건에 미치는 영향Article Published on 2021-03-092022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, 치료법, [키워드] 501Y.V1 501Y.V2 accumulated acute respiratory syndrome Anti-viral antibodies Antibody binding antibody resistance B.1.1.28.1 B.1.1.7 B.1.351 binding Brazil candidate Candidates circulation Clade G clinical COVID-19 COVID-19 vaccines current D614G variant described diagnostic diagnostic sensitivity diagnostic test diagnostic tests Effect epitope followed by functional furin cleavage site higher affinity host receptor Host receptors host tropism Immune escape impacts implication lead lineages Missense modulation molecular molecular dynamics multiple mutation multiple mutations Mutation N501Y N501Y mutation New nucleocapsid ORF8 P.1 Post-vaccine predicted Proteins Public public health public health strategies regions Reinfection resource respiratory roll S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome South Africa Spike protein the S protein therapeutic United Kingdom vaccine delivery variant while [DOI] 10.3390/v13030439 PMC 바로가기 [Article Type] Article
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 20202020년 10월부터 11월까지 영국에서 SARS-CoV-2의 N501Y 돌연변이 균주의 조기 전염성 평가Rapid Communication Published on 2021-01-072022-09-10 Journal: Eurosurveillance [Category] Fulltext, MERS, 바이오마커, 변종, [키워드] 20B/501Y.V1 Amino acid circulating COVID-19 fitness Lineage Lineage B.1.1.7 mutant strain N501Y N501Y mutation new SARS-CoV-2 Receptor-binding domain SARS-CoV-2 Spike protein Spread the receptor-binding domain the spike protein Transmissibility United Kingdom VOC-202012/01 [DOI] 10.2807/1560-7917.ES.2020.26.1.2002106 PMC 바로가기 [Article Type] Rapid Communication
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacyResearch Article Published on 2020-09-252022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] acute respiratory syndrome adaptation adaptive Amino acid animal model Antiviral BALB/c mice coronavirus coronavirus disease COVID-19 Critical deep dependent on develop Efficacy infections Inflammatory response interstitial pneumonia intranasal lung medical intervention mice modeling moderate mouse-adapted strain Mutation N501Y N501Y mutation neutralizing antibody pandemic Pneumonia Protective RBD Receptor binding domain Research respiratory tract response resulting SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain Science Sequencing the receptor-binding domain the spike protein treat Vaccine vaccine candidate vaccine candidates viral pathogenesis viral spike protein viral strain virulence virus was used [DOI] 10.1126/science.abc4730 PMC 바로가기 [Article Type] Research Article