Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseases리툭시맙은 자가면역 질환에서 COVID-19 백신에 대한 B 세포 반응을 손상시키지만 T 세포 반응을 손상시키지 않습니다Article Published on 2022-06-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activated anti-spike antibody response anti-Spike IgG Antibody Response Autoimmune disease autoimmune disease patient BNT162b2 CD4 CD8 CD8 T cell cellular response control group COVID-19 COVID-19 vaccine cytokine dose flow cytometry functional healthy control healthy controls humoral Immunosuppressant immunosuppressants interferon-γ Messenger RNA mRNA Necrosis Neutralization assay neutralizing antibody not different Patient patients patients treated performed Pfizer-BioNTech proportion Responder response rituximab RTX SARS-CoV-2 peptide SARS-CoV-2 spike peptide shown staining T cell response the healthy the vaccine time treated vaccine dose [DOI] 10.1002/art.42058 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine stormFamotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.Article Published on 2022-05-162022-09-11 Journal: Molecular Medicine [Category] 유전자 메커니즘, [키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR [DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms감염 또는 신경학적 증상이 없는 대조군과 비교하여 COVID-19 감염 및 신경학적 증상이 있는 환자의 뇌척수액에서 바이러스 항원 및 염증성 바이오마커Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 95% CI age Antigen Biomarker capture Central nervous system cerebrospinal fluid clinical CNS component Concentration contribute Control control group controls correlated COVID COVID-19 COVID-19 infection COVID-19 severity cross-sectional cross-sectional study CSF Cytokines detectable disease severity Encephalopathy Evidence evidence of Gothenburg Health Organization healthy control highlight IL-10 IL-6 immune activation immune response immune responses immunoassay Infection Inflammatory Inflammatory biomarker inflammatory biomarkers Injury interferon interferon γ interleukin IQR male median microglobulin moderate Moderate COVID-19 Necrosis neurologic neuronal no differences nucleocapsid antigen Older outcome participant Participants Pathogenesis Patient patient groups platform Principal component principal component analysis Protein Sahlgrenska University Hospital SARS-COV-2 infection SARS-CoV-2 nucleocapsid scale severe COVID-19 severe disease significantly significantly higher Study protocol Swedish Symptom Symptoms test results Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Viral Viral antigen viral invasion Viral RNA was performed with COVID-19 World Health Organization β2-microglobulin [DOI] 10.1001/jamanetworkopen.2022.13253 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort studyCOVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구Article Published on 2022-05-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China [DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article
Gut microbiota-derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID-19: An open-label pilot studyCOVID-19에 대한 새로운 보조 요법으로서 장내 미생물총 유래 신바이오틱 포뮬라(SIM01): 오픈 라벨 파일럿 연구Article Published on 2022-05-012022-09-12 Journal: Journal of gastroenterology and hepatology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Admission Analysis antibody formation Antibody Response bacterial specy bifidobacteria changes in commensal bacteria Control control group controls COVID-19 COVID-19 patient database Day develop discharge Effect fecal greater Gut gut microbiota healthy Hong Kong hospital hospitalised COVID-19 patients hospitalized COVID-19 patients IgG antibody IL-1ra immune dysfunction immune markers Immunity Immunological response IMPROVE independent Infectious disease Intervention M-CSF Macrophage MCP-1 metagenomic microbiota monocyte chemoattractant protein-1 nasopharyngeal nasopharyngeal viral load Necrosis Open-label outcome pathogen Patient pilot study plasma positive pro-inflammatory Probiotics proinflammatory protocol receive receiving reduced restored SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 viral load severity of COVID-19 significant negative correlation significantly standard treatment Strains suggested therapy TNF-α were given [DOI] 10.1111/jgh.15796 PMC 바로가기 [Article Type] Article
Association of tumor necrosis factor alpha -308 single nucleotide polymorphism with SARS CoV-2 infection in an Iraqi Kurdish population이라크 쿠르드족 인구에서 SARS CoV-2 감염과 종양 괴사 인자 알파 -308 단일 염기 다형성의 연관성Article Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha association caused coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 infections COVID-19 patients expression General population Genetic variations Genotype genotyping heterozygous homozygous immune dysregulation increase Infection infections Infectious disease Infectious diseases innate immune gene innate immune genes Iraq mutant Necrosis organ damage p value Patient patients polymerase chain reaction polymorphism Population promoter region Protein risk factor Risk factors Sample size SARS CoV SARS CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly single nucleotide single-nucleotide single-nucleotide polymorphism SNP the disease TNF TNF- 308 TNF-α Tumor tumor necrosis tumor necrosis factor Variation was used [DOI] 10.1002/jcla.24400 PMC 바로가기 [Article Type] Article
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19COVID-19와 관련된 어린이의 다기관 염증 증후군에서 내피 글리코칼릭스 분해Article Published on 2022-05-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome Admission Adult patients affecting Biomarker Blood children children with MIS-C chondroitin chondroitin sulfate collected Complication Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Cytokines Degradation Deterioration disease severity elevated endothelial Endothelial dysfunction Endothelium Future glycocalyx healthy hemodynamic heparan sulfate Infection Inflammation Inflammatory Injury intensive care lead marker MIS-C myocardial injury Necrosis Patient Potential biomarker potential biomarkers Predictive proinflammatory cytokines respiratory severe acute respiratory syndrome Coronavirus severe COVID-19 severity Shock suggested sulfate Support syndecan Syndecan-1 syndrome TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α Urine vasopressors [DOI] 10.1007/s00109-022-02190-7 PMC 바로가기 [Article Type] Article
Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort예방 접종을 받지 않은 코호트에서 SARS-CoV-2에 대한 체액 면역 반응의 유병률, 혈청 전환율 및 수명에 대한 사이토카인 억제제 요법의 영향Article Published on 2022-05-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI adjusted Against age analyzed biologic calculate Care confidence interval Control controls COVID-19 driven by evaluated First wave Follow-up Health humoral immune response IgG antibody IL-17 IL-23 Immune-mediated inflammatory disease Impact inhibitors less Longevity Necrosis not significantly different participant Patient patients treated PCR-positive polymerase chain positive Prevalence prospective cohort Rate receiving reduced Regression response risk RRs SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG antibody SARS-COV-2 infection Seroconversion seroconversion rate seroconvert Sex significantly lower tested Treatment were assessed were measured were used [DOI] 10.1002/art.42035 PMC 바로가기 [Article Type] Article
Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review급성 충수염으로 나타난 급성 괴사성 아메바 대장염: 사례 보고 및 포괄적 문헌 검토Article Published on 2022-04-302024-08-22 Journal: J Infect Dev Ctries [Category] 세균성이질, [키워드] Amoebiasis Indonesia intestinal metronidazole Necrosis