The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review코로나바이러스 질병-2019(COVID-19)에 대한 고압산소 요법(HBOT)의 효과: 체계적인 검토Review Published on 2021-08-192022-09-11 Journal: European Journal of Medical Research [Category] MERS, SARS, 임상, [키워드] adverse event adverse events article assessment tool Blood oxygen saturation clinical trial clinical trials cornerstone coronavirus country COVID-19 COVID-19 treatment database demonstrated Effect effective Efficacy eligible Evidence fair quality Health hyperbaric oxygen Hyperbaric oxygen therapy Hyperbaric oxygenation knowledge less mechanism MOST NIH oxygen Oxygen therapy Oxygenation patients with COVID-19 Prospective PROSPERO receiving Registered reported Result retrieved review Safe SARS-CoV-2 screening process searched systematic review systematic reviews the patient Treatment was used Web of Science [DOI] 10.1186/s40001-021-00570-2 PMC 바로가기 [Article Type] Review
Midcareer Medical School Research Faculty Perspectives on Vitality and Professionalism During the COVID-19 PandemicCOVID-19 전염병 동안 활력과 전문성에 대한 중견 의과 대학 연구 교수의 관점Research Published on 2021-08-132022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] addition affected Analysis appear association Burnout careers contributing to Course COVID-19 COVID-19 pandemic determine dominant Effects Efficacy enrolled faculty finding focus Gender grounded theory Health Impact implication Importance inclusion criteria inquiry intrinsic investigator investigators leadership measure mechanism medical school mental health NIH objective offered pandemic participant Participants participated Point positive produced professionalism Psychological Psychological stress qualitative analysis question randomized trial Randomly recipient Relevance reported Research response response rate responses Result School selected sense setting Sex Social Justice stratified vitality women working [DOI] 10.1001/jamanetworkopen.2021.20642 PMC 바로가기 [Article Type] Research
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19성체 줄기 세포 유래 완전한 폐 오르가노이드 모델은 COVID-19에서 폐 질환을 모방합니다Tools and Resources Published on 2021-08-132022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] airway airway epithelia alveolar Alveolar Type II AT2 AT2 differentiation cause Cell cells center clinical Cohort Complete component computational COVID-19 COVID-19 pathogenesis Critical Diego disease modeling distal finding Host immune response Human human lung Illumina immune response immunologist in vitro include lung Lung disease lung organoid manuscript Medicine monolayer NIH NovaSeq 6000 pneumocyte Program proximal Respiratory samples responsible SARS-CoV-2 SARS-CoV2 scientist STEM supported sustained System therapy transcriptomic Vaccines viral infection virus viruses were infected widespread [DOI] 10.7554/eLife.66417 PMC 바로가기 [Article Type] Tools and Resources
Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19유행성 건강 위기 동안 치료 지침 개발: COVID-19에서 배운 교훈Article Published on 2021-08-012022-09-11 Journal: Annals of internal medicine [Category] SARS, 신약개발, [키워드] approaches biostatistics Care clinical evidence Clinical studies clinical study Community COVID-19 Developing evaluated Evidence force guideline Health Health care individual initial Initially lesson NIH Panel provided public health randomized clinical trial recommendation recommendations representing request Study design subsequent Task Force therapeutic agent took place Treatment White House [DOI] 10.7326/M21-1647 PMC 바로가기 [Article Type] Article
Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness혈장 1,3-β-d-글루칸 수치는 중환자에서 불리한 임상 결과를 예측합니다Clinical Medicine Published on 2021-07-222022-09-10 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] Acute respiratory failure adjusted Analysis ARF association Award Biomarker cell wall circulation clinical Clinical outcome collected COVID-19 Critical Critical illness Critically ill Critically ill patient critically ill patients Cytokines enrolled epithelial epithelial permeability fungal fungal cell wall Fungal infection fungal infections fungi Gut healthy controls higher odd higher odds hospitalized patient Host host inflammatory response Hyperinflammatory Infectious disease Inflammation Inflammatory responses information Innate immunity invasive lung mechanically ventilated patient mechanism median Microbiology NIH offer offered outcomes pathogen pathogen-associated molecular Patient Pittsburgh plasma plasma samples predict Predictive prognostic Research Respiration Respiratory failure Science significantly higher stimulate Stimulation suggested survival systemic circulation therapeutic translocation university ventilator-free day with COVID-19 [DOI] 10.1172/jci.insight.141277 PMC 바로가기 [Article Type] Clinical Medicine
Prevalence and Predictors of Prolonged Cognitive and Psychological Symptoms Following COVID-19 in the United StatesNeuroscience Published on 2021-07-192022-10-31 Journal: Frontiers in Aging Neuroscience [Category] COVID-19, [키워드] 95% CI activity adjusted age Analysis Anxiety average coded cognitive Community Community Dwellers conducted Contact covariate covariates COVID-19 COVID-19 negative COVID-19 positive subjects COVID-19 symptoms demographics Depression diagnosed Diagnosis disorder dysfunction eligible participant Factor fatigue female greater group Hispanic identify initial Laboratory testing logistic regression model Long-hauler male measure median Metrics multivariable logistic regression NIH no significant difference not differ occurred participant Participants past medical history platform positive Post-acute sequelae of SARS-CoV-2 infection predict Predictive predictor Prevalence Primary outcome Prolonged proportions psychological symptom Quantitative reported Research Result Sex significantly significantly higher stressors subjects subsequent Symptom the United State typical symptoms United State [DOI] 10.3389/fnagi.2021.690383 PMC 바로가기 [Article Type] Neuroscience
Comparison of IgG and neutralizing antibody responses after one or two doses of COVID-19 mRNA vaccine in previously infected and uninfected individuals.Research article Published on 2021-07-132022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, 진단, [키워드] ACE2 analysed Anti-RBD IgG anti-SARS-CoV-2 Anti-spike RBD IgG Chicago collected Concentration COVID-19 COVID-19 diagnosis diagnosed with COVID-19 Diagnosis diagnostic dose Dried blood spots elicit ELISA enzyme evaluated female finding foundation funding generate Hospitalization IgG IgG antibody Immunity in vitro individual individuals infected with SARS-CoV-2 Interaction median median age mRNA vaccination mRNA vaccine mRNA-1273 vaccine neutralization Neutralizing Neutralizing antibody response NIH of BNT162b2 office participant positive Post-vaccine RBD reached recent Receptor binding Receptor binding domain recipients reported response Sample SARS-CoV-2 Science Serological testing seronegative seropositive Serosurvey significantly higher suggested two group uninfected unique university vaccination Vaccine vaccine dose virus [DOI] 10.1016/j.eclinm.2021.101018 [Article Type] Research article
Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibilityArticle Published on 2021-07-062022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] Adults all age group assessment Asymptomatic calculate children Clinical outcome clinically conducted contact-tracing study COVID-19 COVID-19 pandemic Critical disease estimate Evidence First wave identify Inclusion Infants Infection Infectious diseases information initial literature review Meta-analysis Mild NIH outbreak pandemic Patient peer-reviewed study positive proportion Quality random effect recruitment reported SARS-COV-2 infection Schools Serosurvey severity Study protocol surveillance data susceptibility Symptom systematic review the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 viral infection [DOI] 10.1038/s41598-021-92500-9 PMC 바로가기 [Article Type] Article
The Yin and the Yang of Transformative Research During the COVID-19 Pandemic—A PerspectiveCOVID-19 팬데믹 기간 동안의 변혁적 연구의 음과 양 - 관점Pediatrics Published on 2021-06-242022-09-10 Journal: Frontiers in Pediatrics [Category] 비임상, [키워드] adaptive animal models approach basic and clinical sciences breath broad scientific training capture Clinical research clinical trial complex disease COVID-19 COVID-19 pandemic develop domain effort facilitate highlight humanized limitation methodology mitigate model system NIH partnership pathophysiology pediatric Perspective Precision rare and complex disease Research researcher seamless singular Systems biology training & development transformative team science Translational research [DOI] 10.3389/fped.2021.650302 PMC 바로가기 [Article Type] Pediatrics
Therapeutic Effectiveness and Safety of Repurposing Drugs for the Treatment of COVID-19: Position Standing in 2021Pharmacology Published on 2021-06-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affected approval approved Case series China Chloroquine clinical trials Cohort studies contagious COVID-19 COVID-19 infections doxycycline drug drug candidate effective Favipiravir globe Health Hydroxychloroquine in silico approaches in vitro in vivo information investigated Ivermectin knowledge lack Lopinavir-ritonavir management meta-analyses NIH pandemic pharmacological position Preliminary data Prophylaxis protease inhibitors Remdesivir repurposing repurposing drugs researcher Retrospective study rivaroxaban Safety SARS-CoV-2 Stage Standing therapeutic option transmitted Transport Treatment Vaccines viral outbreak viral pathogenesis World Health Organization [DOI] 10.3389/fphar.2021.659577 PMC 바로가기 [Article Type] Pharmacology