Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?COVID-19 환자의 비타민 D 상태와 염증 반응 사이에 중요한 연관성이 있습니까?Clinical Trial Published on 2022-01-242022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] 25OHD 25OHD level 25OHD levels adjusted age and sex biochemical Clinical data cohort of patient Complete consecutive patient coronavirus disease correlation COVID-19 CRP Cytokine storm D-dimer Effect evaluate evaluated group hospital Hospitalization hypovitaminosis Hypovitaminosis D IL-10 IL-6 Infection Inflammatory marker inflammatory markers inverse correlation management marker non-survivor P/F ratio Patient patients Pneumonia poor prognosis prevalent response Result risk factor SARS-CoV-2 secondary endpoint severe ARDS severity significantly higher status suggested the disease TNF-α Vitamin D Vitamin D status with COVID-19 [DOI] 10.3389/fimmu.2021.745713 PMC 바로가기 [Article Type] Clinical Trial
A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation입원 4일 후 입원한 Covid-19 환자의 사망률을 예측하는 모델: 개발, 내부 및 시간-외부 검증Cellular and Infection Microbiology Published on 2022-01-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] Admission age Alpha Alpha variant AUROC B.1.1.7 blood parameter C-reactive protein calibration slope Care characteristic clinical coronavirus COVID-19 creatinine cross Day develop development discharge explained Fever Final FIVE haematological parameter haematological parameters Health Health care Health care system Hospitalized hospitalized COVID-19 patients hospitalized patients hospitals Identifier in-hospital mortality internal Lactate lactate dehydrogenase linear mixed model Logistic regression Model Mortality mutations non-survivor Non-survivors objective Occurrence on admission parameter Patient Platelet Platelet count Prediction model prevalent prognostic model receiver operating characteristic receiver operating characteristic curve reduce Registration Result slope Support supported survival survivor validation variable variable selection variables Variation was done [DOI] 10.3389/fcimb.2021.795026 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Prophylactic versus therapeutic dose anticoagulation effects on survival among critically ill patients with COVID-19Research Article Published on 2022-01-192022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% CI Acute kidney injury age AKI Analysis anticoagulation cardiovascular disease characterized Clinical characteristics conducted covariate-adjusted COVID-19 patient Critically ill Critically ill patient death deaths dose Effect groups help High dose high risk higher risk Hospitalization ICU ICU admission identify In-hospital death in-hospital mortality incidence incidence rate independent Lymphocyte count male material mortality rate New York non-survivor Older outcome Patient Prophylactic raise Result retrospective risk factor severe COVID-19 survival survival curve therapeutic thrombotic event Thrombotic events Treatment university with COVID-19 [DOI] 10.1371/journal.pone.0262811 PMC 바로가기 [Article Type] Research Article
Association of genetic variations in ACE2 , TIRAP and factor X with outcomes in COVID-19Research Article Published on 2022-01-072022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome candidate gene carrier caused Clinical course Clinical outcome conducted coronavirus Coronavirus disease 2019 COVID-19 defined died disease severity Diseases distribution Endotracheal intubation female Genetic polymorphism Genetic variation influence investigated mechanical ventilation median age Mortality nasal oxygen non-survivor Non-survivors not differ outcome oxygen Patient polymerase chain polymorphism predisposition quartile required respiratory Respiratory failure Result retrospective cohort study rs2285666 SARS-CoV-2 SARS-COV-2 infection significantly lower Single nucleotide polymorphism survivor tirap treated Venous Thromboembolism were assessed [DOI] 10.1371/journal.pone.0260897 PMC 바로가기 [Article Type] Research Article
Predictors of COVID-19 Mortality in Critically Ill ICU Patients: A Multicenter Retrospective Observational StudyInternal Medicine Published on 2022-01-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome addition age Analysis appear Asymptomatic BMI categorical variable caused Characteristics chi-square test Chronic kidney disease chronic obstructive Comorbidities Comorbidity conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP diabetes died disease severity elevated Factor hospital hypertension ICU ICU patient Ill independent risk factor less Mortality mortality rate multicenter multisystemic disease multivariate Cox regression non-survivor Patient predict pulmonary disease regression analysis Result retrospective SARS-CoV-2 severe disease severe respiratory disease study period survived survivor t-test Tachycardia those that survived USA variables with COVID-19 [DOI] 10.7759/cureus.20952 PMC 바로가기 [Article Type] Internal Medicine
Delayed inflammation decrease is associated with mortality in Tocilizumab-treated critically ill SARS-CoV-2 patients: A retrospective matched-cohort analysis지연된 염증 감소는 Tocilizumab 치료 중환자 SARS-CoV-2 환자의 사망률과 관련이 있습니다. 후향적 일치 코호트 분석Multicenter Study Published on 2022-01-012022-09-11 Journal: Innate immunity [Category] 바이오마커, 진단, 치료제, [키워드] Admission Analysis association baseline level baseline levels C-reactive protein collected Critically ill cytokine decrease Delayed fibrinogen Fibrinogen levels Gender IL-6 immuno-inflammatory increase in Inflammation Inflammatory biomarker inflammatory biomarkers intensive care intensive care unit mechanical ventilation Mortality multicenter non-survivor Non-survivors not different outcome Patient patients persistent plasma Plasma levels Pneumonia Protein retrospective retrospective cohort SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV2 survivor Tocilizumab Treatment [DOI] 10.1177/17534259211064602 PMC 바로가기 [Article Type] Multicenter Study
Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study가용성 TNF 수용체는 중환자 COVID-19 환자의 급성 신장 손상 및 사망률을 예측합니다: 전향적 관찰 연구Observational Study Published on 2022-01-012022-09-11 Journal: Cytokine [Category] SARS, 바이오마커, 임상, [키워드] 30-Day mortality Activation Acute kidney injury addition age AKI an area association Biomarker Biomarkers Blood donors characteristic collected Control control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical care Critically ill Critically ill patient critically ill patients cut-off demographic demographic data develop ferritin hallmark healthy blood donor ICU ICU admission IL-6 Illness severity immune cascade independent Inflammation Inflammatory inflammatory biomarkers Informed consent involved kidney Level Mortality multiple organ failure non-survivor Organ failure organs outcome Patient PCR-confirmed COVID-19 PCT plasma Plasma level Plasma levels Pneumonia predict prospective observational study quantified receiver receiver operating characteristic receptor receptors Respiratory failure Septic shock severe COVID-19 patient severe COVID-19 patients severe disease severity severity of illness SOFA sTNFR survival survivor systemic inflammatory processe TNF TNF receptors. TNFα were used with COVID-19 [DOI] 10.1016/j.cyto.2021.155727 PMC 바로가기 [Article Type] Observational Study
Oral Health of COVID-19 Patients Using Extracorporeal Membrane Oxygenation: A Clinical Study of 19 CasesArticle Published on 2021-12-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] age BMI body mass index clinical condition consecutive patient coronavirus disease COVID-19 COVID-19 patient Deterioration ECMO Extracorporeal extracorporeal membrane oxygenation Factor Frequency Gingiva group Health ICU intensive care investigated median membrane Mortality no significant difference non-survivor Non-survivors oral oral condition Patient receiving remaining teeth Respiratory failure Saliva severe COVID-19 patient Sex significant difference significantly higher survival survivor Survivors total score Treatment two group Univariate analysis university [DOI] 10.3390/jcm11010042 PMC 바로가기 [Article Type] Article
Impairment of T cells’ antiviral and anti-inflammation immunities may be critical to death from COVID-19Mathematics Published on 2021-12-222022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] age Anti-inflammation anti-inflammatory responses antibodies Antiviral antiviral response approach Clarifying Clinical data COVID-19 COVID-19 mortality Critical cytokine death dominant Factor functional heterogeneity immune immune response immune system Immunity Immunology and inflammation Inflammation lack males mathematical model mild patient Mortality non-survivor Non-survivors Patient provide quantification significantly Simulation suppressed survivor T cell tissue tissue repair Treatment Vaccine viral dynamics virus virus clearance yielding [DOI] 10.1098/rsos.211606 PMC 바로가기 [Article Type] Mathematics
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-AnalysisMedicine Published on 2021-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] AST/ALT AUC Coronavirus 2019 coronavirus—COVID-19 COVID-19 database De Ritis ratio diagnostic eight elevated ICU care intubation likelihood ratio liver enzyme mean differences Meta-analysis Mortality negative and positive NLR non-survivor Odds ratio outcome Patient patients patients with COVID-19 Poor poor prognosis posterior probability Ratio review SARS-CoV-2 sensitivity Sensitivity and specificity severity specificity subgroup analysis systematic literature search transaminase was performed [DOI] 10.3389/fmed.2021.676581 PMC 바로가기 [Article Type] Medicine