Gargle lavage & saliva: Feasible & cheaper alternatives to nasal & throat swabs for diagnosis of COVID-19양치질 세척 및 타액: COVID-19 진단을 위한 비강 및 인후 면봉에 대한 실행 가능하고 저렴한 대안Article Published on 2021-05-012022-09-11 Journal: The Indian journal of medical research [Category] SARS, 치료기술, [키워드] agreement Analysis Chain Reaction Clinical use collected conducted COVID-19 Ct values cycle threshold diagnosis of COVID-19 E gene gargle gargle lavage healthcare worker Healthcare workers lavage medium N gene nasal nasal swab no significant difference no significant differences normal saline NTS ORF ORF gene Other patients polymerase chain polymerase chain reaction positive COVID-19 processed real-time RT-PCR reduce reverse transcription reverse transcription polymerase chain reaction RNA RNA stability rRT-PCR RT-PCR Saliva saliva samples Sample sample collection SARS-CoV-2 SARS-CoV-2 RNA significant differences specimen specimen collection stability subset the SARS-CoV-2 throat swab Transport transport medium unavailability Viral load workload [DOI] 10.4103/ijmr.IJMR_4209_20 PMC 바로가기 [Article Type] Article
Unravelling the early warning capability of wastewater surveillance for COVID-19: A temporal study on SARS-CoV-2 RNA detection and need for the escalationCOVID-19에 대한 폐수 감시의 조기 경보 기능 풀기: SARS-CoV-2 RNA 탐지 및 확대 필요성에 대한 임시 연구Article Published on 2021-05-012022-09-11 Journal: Environmental research [Category] SARS, 치료기술, [키워드] analyzed approach Asymptomatic case average can not city clinical test Clinical tests Concentration confirmed case confirmed cases coronavirus COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic declined Early warning system Escalation fluctuation Genome help hotspot hour identify India lead management offer ORF pandemic plant positive pre-symptomatic predict Registered S-gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA SARS-CoV-2 RNA detection study period Surveillance Treatment Variation wastewater wastewater based epidemiology wastewater surveillance water [DOI] 10.1016/j.envres.2021.110946 PMC 바로가기 [Article Type] Article
Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity초기 유행병 동안 SARS-CoV-2 감염의 게놈 역학 및 질병 중증도와의 연관성Research Published on 2021-04-262022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 변종, [키워드] 95% CI Admission age Alter Analysis association circulation clade clades Cleveland clinic clinical outcomes clinical risk Community complex creatinine cross-sectional cross-sectional study D614G Data analysis demonstrated died disease disease severity explain finding followed by Frame Frequency Genotype group help Hospitalization Hospitalized ICU ICU admission Identified Importance Increased increased survival infected with SARS-CoV-2 Infection Influenza initial initiative intensive care intensive care unit Kruskal-Wallis Laboratory male measure median Mortality mortality rates multivariable analysis objective occurred Odds ratio Open reading frame ORF ORF8 other variants outcome outcomes overall mortality pandemic progresses participant Patient patient survival patients with SARS-CoV-2 Point reduction in Relevance required Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants setting several variants significantly specimen specimens spike strain Strains Stratification the patient understanding unique variant variants Viral viral genome viral genome analysis Viral genome sequencing virus was performed Wave white [DOI] 10.1001/jamanetworkopen.2021.7746 PMC 바로가기 [Article Type] Research
SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike ParticlesSARS CoV-2 핵단백질은 렌티바이러스 스파이크 입자의 감염성을 향상시킵니다Cellular and Infection Microbiology Published on 2021-04-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료법, [키워드] ACE2 ACE2-Fc BSL-2 cells cellular entry D614G enhancer Entry inhibitor entry inhibitors fused Genes implication Infectivity Interpretation lentiviral less mutant N protein Neutralizing neutralizing effect nucleocapsid nucleoprotein ORF Particle particle infectivity Particles pathogen performed produced SARS CoV SARS CoV-2 SARS-CoV-2 spike spike lentiviral pseudotyping Spike protein the spike protein virion virions Virus neutralization while wild-type [DOI] 10.3389/fcimb.2021.663688 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patientsResearch Articles Published on 2021-04-142022-10-28 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation CD8 Complete complex COVID-19 COVID-19 patient COVID-19 patients disease disease severity effective epitope epitope mapping Epitopes evaluated Frame healthy donor Immunity immunodominance immunodominant immunodominant epitopes immunogenic in healthy individuals lymphocyte MHC MOST ORF ORF1 ORF3 outcomes overlapping Patient peptide phenotype Population Region reveal robust SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection severe disease significantly subset T cell T cell activation T cell epitopes T cell phenotype T cell response T cells the SARS-CoV-2 genome viral clearance virus-infected cell with COVID-19 with mild disease [DOI] 10.1126/sciimmunol.abf7550 PMC 바로가기 [Article Type] Research Articles
Subgenomic RNA identification in SARS-CoV-2 genomic sequencing dataMethod Published on 2021-04-012022-10-31 Journal: Genome research [Category] COVID-19, SARS, [키워드] 5′ UTR ACE2 Analysis applied arising canonical canonical sgRNA Cell cell lines changes in comprehensive analysis COVID-19 sample data set detect determine discontinuous transcription expected genomic RNA genomic sequence genomic sequencing homology identify in vitro leader sequence Local occur Open reading frame ORF ORF10 ORFs produced quantification replicate RNA RNA genome SARS-CoV-2 SARS-CoV-2 genome sequenced sequencing data sgRNA start codon the SARS-CoV-2 transcription regulatory sequence translation transmitted TRS-B TRS-L United Kingdom upstream variant [DOI] 10.1101/gr.268110.120 PMC 바로가기 [Article Type] Method
Prevalence of COVID-19 Positive Cases Diagnosed by Real time Polymerase Chain Reaction in a Tertiary Care Hospital of Nepal네팔 3차 병원에서 실시간 중합효소 연쇄반응으로 진단한 코로나19 양성 사례의 유병률Original Article Published on 2021-03-312022-09-10 Journal: JNMA: Journal of the Nepal Medical Association [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus-2 age Asymptomatic asymptomatic patient asymptomatic patients Care cause chain Chain Reaction chain reactions China collected conducted confirmation contagious Corona Corona virus cough COVID-19 cross-sectional cross-sectional study Cycle threshold value diagnosed females Fever focus health system hospital include individual Infection introduced majority male management MOST Nepal nucleic acid nucleic acid amplification nucleic acid amplification tests ORF patients worldwide polymerase chain polymerase chain reaction polymerase chain reactions positive presenting symptom presenting symptoms prevalence of COVID-19 processed reaction Reactions real-time polymerase chain reaction reported resource respiratory reverse transcriptase Reverse transcriptase polymerase chain reaction Ribonucleic acid severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sick Swab Symptom symptomatic cases Tertiary variant Viral viral gene viral genes viral ribonucleic acid virus was done [DOI] 10.31729/jnma.5992 PMC 바로가기 [Article Type] Original Article
Identification of the RNase-binding site of SARS-CoV-2 RNA for anchor primer-PCR detection of viral loading in 306 COVID-19 patients306명의 COVID-19 환자에서 앵커 프라이머-PCR 검출을 위한 SARS-CoV-2 RNA의 RNase 결합 부위 식별Multicenter Study Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anchor primer bioinformatics Bioinformatics analysis bioinformatics analysis. Chain Reaction confirmed case confirmed cases convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cycle threshold value demonstrated Diagnosis feces first positive Gender identification IMPROVE male molecular Molecular diagnosis N gene nasal nuclear Older age ORF ORF gene pandemic Pharyngeal swab polymerase chain polymerase chain reaction primer reveal RNA RNase SARS-CoV-2 SARS-CoV-2 RNA sensitivity severe acute respiratory syndrome Coronavirus sputum stability supported Urine Viral RNA [DOI] 10.1093/bib/bbaa193 PMC 바로가기 [Article Type] Multicenter Study
SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island lociSARS-CoV-2 핫스팟 돌연변이는 역 반복 및 CpG 섬 유전자좌 내에서 상당히 풍부합니다Case Study Published on 2021-03-212022-09-10 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] Analysis bioinformatics carried cause Coronaviridae family COVID-19 disease CpG CpG methylation creating decrease effort genomic hot spot humans inverted repeats investigated life cycle limit loci Mutation Nidovirale Nidovirales ORF predict progression SARS-CoV-2 SARS-CoV-2 genome sequenced significantly the disease the SARS-CoV-2 genome Transcription upstream Viral viral life cycle viral strain viral strains virus [DOI] 10.1093/bib/bbaa385 PMC 바로가기 [Article Type] Case Study
Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccinesReview Published on 2021-03-152022-10-28 Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, MERS, SARS, [키워드] accessory protein Analysis antiviral effects cellular chemokine clinical symptom complexes coronavirus coronavirus strain COVID-19 COVID-19 patient Cytokines storm DNA repair domains driven by Effectiveness Evolution facilitate Factor Frame function functional Genome Genome sequences global pandemic help Host host cell host cells Immunity immunological resistance independent Inflammation inhibit innate immune cell interferon Lung injury mutated Mutation Non-synonymous ORF ORF1b Pathogenesis patients Perspective Protein provided receptor Recombination recruit Replication RNA RNA genome SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 vaccine specific mutation Spread strain structures suppress the spike protein translation understanding Vaccine Vaccines Viral RNA viral RNA synthesis virion virus virus entry Virus evolution virus infection [DOI] 10.1590/1414-431X202010725 PMC 바로가기 [Article Type] Review