organoids – Page 6 – Communicable Diseases Research

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

Medicine

Published on 2021-05-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery

Article

Published on 2021-05-012022-10-29
Journal: Stem cell research [Category] COVID-19, MERS, SARS,

Review of studies of severe acute respiratory syndrome related coronavirus–2 pathogenesis in human organoid models

Review

Published on 2021-03-252023-06-14
Journal: Reviews in Medical Virology [Category] MERS, SARS,

[키워드] antivirals COVID‐19 immune response organoids Pathogenesis SARS‐CoV‐2
[DOI] 10.1002/rmv.2227 PMC 바로가기 [Article Type] Review

Potential of CRISPR/Cas13 System in Treatment and Diagnosis of COVID-19

Review Article

Published on 2021-03-252022-10-31
Journal: Global Medical Genetics [Category] COVID-19,

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Article

Published on 2021-03-162023-06-15
Journal: Cell [Category] Fulltext, MERS,

[키워드] Bromodomain and extraterminal family inhibitors COVID-19 Drug discovery heart Inflammation organoids
[DOI] 10.1016/j.cell.2021.03.026 PMC 바로가기 [Article Type] Article

Islet organoid as a promising model for diabetes

Review

Published on 2021-03-102022-10-29
Journal: Protein & Cell [Category] COVID-19, COVID19(2023년), SARS,

Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon

염증이 있는 IBD 조직에서 SARS-CoV-2의 장 수용체는 회장에서 HNF4A에 의해 하향 조절되고 결장에서 인터페론 조절 인자에 의해 상향 조절되는 것으로 보입니다

Article

Published on 2021-03-052022-09-11
Journal: Journal of Crohn's & colitis [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression Alter analysed Analysis anti-TNF biopsy bowel Co-expression analysis collected Colon colonic Control COVID-19 Crohn's disease Cytokines Differential gene expression disease dysregulation entry mechanisms epithelial Factor HNF4A IBD IBD susceptibility gene ileal ileum Immunosuppressed inflamed CD ileum Inflammation Inflammatory Inflammatory bowel disease inflammatory bowel diseases inflammatory stimuli interferon intestinal intestinal inflammation intestine investigated Microarray Microarrays mucosal Necrosis network Organoid organoids Patient patients pro-inflammatory cytokine pro-inflammatory cytokines processed Prognosis regulated Regulating Regulation responders restored risk factor RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data shown significantly Single Cell single-cell therapy tissue TMPRSS2 transcriptomics ulcerative colitis upregulated upstream
[DOI] 10.1093/ecco-jcc/jjaa185 PMC 바로가기 [Article Type] Article

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

IFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다

Report

Published on 2021-03-032022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission
[DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report

SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids

줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링

Review

Published on 2021-02-262022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, 진단,

[키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus
[DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

TMPRSS2 발현에 대한 독특한 메커니즘은 엔잘루타미드에 의한 SARS-CoV-2 감염의 기관 특이적 억제를 설명합니다

Article

Published on 2021-02-082022-09-10
Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiandrogen antiviral action antiviral activity antiviral efficacy approved binding binding pattern Cancer cells caused Cell cells clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drugs Effect Efficacy enzalutamide epithelial cells evaluated Evidence explain expression Gene regulation global public health hACE2 human lung human lung cell human lung cells human lung organoid human lung organoids in vivo inhibited knockout mice lack locus lung cancer lung cell lung cells mechanism mediator mice organ-specific organoids pandemic Prostate Prostate cancer protective role reduce reducing Regulatory Repurposed drug respiratory SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus significantly Support therapeutic efficacy TMPRSS TMPRSS2 TMPRSS2 expression Tmprss2 knockout transmembrane serine protease transmembrane serine protease 2 treating COVID-19
[DOI] 10.1038/s41467-021-21171-x PMC 바로가기 [Article Type] Article