Nucleocapsid (N) Gene Mutations of SARS-CoV-2 Can Affect Real-Time RT-PCR Diagnostic and Impact False-Negative ResultsSARS-COV-2의 NucleoCapsid (N) 유전자 돌연변이는 실시간 RT-PCR 진단에 영향을 줄 수 있으며 거짓 음성 결과에 영향을 줄 수 있습니다.Communication Published on 2021-12-102022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] Affect affecting alteration amino acids annealing Brazil Can caused chain Chain Reaction characterization circulation Continuous continuous monitoring COVID-19 COVID-19 pandemic Deletion diagnosis of COVID-19 diagnostic diagnostic test disorder Effectiveness envelope false false-negative false-negative results frameshift frameshift mutation GeneFinder genomic gold gold standard identify Impact intrinsic lead maintain Mutation N gene network nucleotide nucleotides pathogenicity phenotypic polymerase chain reaction polymerase chain reaction) positive sample primer Primers probe probes protein level RdRP reaction real-time RT-PCR Result reverse transcription polymerase chain reaction RNA polymerase RNA-dependent RNA polymerase RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variants SARS-CoV-2 virus sequenced sequenced sample Substitution Surveillance the SARS-CoV-2 virus Transmissibility Vaccine virus [DOI] 10.3390/v13122474 PMC 바로가기 [Article Type] Communication
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike proteinSARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.Article Published on 2021-12-012022-09-11 Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘, [키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased [DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article
Characterizing Long COVID: Deep Phenotype of a Complex Condition긴 COVID 특성화: 복잡한 상태의 깊은 표현형Review Published on 2021-12-012022-09-12 Journal: EBioMedicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute COVID-19 Analysis applied approach article assist authors can be used clinical feature Clinical finding clinical manifestation Clinicians clinicians and researcher Cohort cohorts condition COVID Covid patients COVID-19 creating curated deep described Diagnosis help heterogeneous HPO term HPO terms Human human disease human phenotype ontology IMPROVE lack Long Long COVID manifestation Manifestations manuscript mapped median Numerous of post-acute sequelae of SARS-CoV-2 ontological PASC Patient percentage phenotype phenotypic phenotypic abnormality phenotyping. reported researchers SARS-CoV-2 self-report questionnaire standard medical terminology Stratification Symptom synonym terminology Treatment unique [DOI] 10.1016/j.ebiom.2021.103722 PMC 바로가기 [Article Type] Review
COVID-19 clinical phenotypes and short-term outcomes: differences between the first and the second wave of pandemic in ItalyObservational Study Published on 2021-12-012022-10-05 Journal: Expert review of respiratory medicine [Category] SARS, 임상, [키워드] acute respiratory distress analyzed ARDS assisted ventilation changed chronic condition Clinical characteristics Clinical features clinical outcomes clinical phenotype clinical risk consecutive patient coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient Critical care death rate disease help Intermediate RICU Italy laboratory result laboratory-confirmed medical treatment Multimorbidity outcome pandemic Patient patients hospitalized patients with ARDS phenotypic Pneumonia Respiratory Support retrospective second wave Stage survival syndrome the SARS-CoV-2 transfer Treatment triggering two group virus [DOI] 10.1080/17476348.2021.1960824 PMC 바로가기 [Article Type] Observational Study
Genome-wide association study of hospitalized COVID-19 patients in the United Arab EmiratesResearch article Published on 2021-12-012022-10-05 Journal: EBioMedicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory distress airway Analysis ARDS association carried conducted coronavirus COVID-19 COVID-19 patient COVID-19 severity cross-sectional CTSC demonstrated differential expression East Asian eight emphysema European expressed expression facilitate FBXO34 finding funding Genetic genetics Genome group GWAS heterogeneity Hospitalized hospitalized COVID-19 patient host cell receptor IMPROVE Inflammation Inflammatory cytokines loci locus lung manuscript mechanical ventilation support Meta-analysis METTL21C mitigate multi-organ failure participant Participants PDE8B Phenotypes phenotypic Pneumonia populations progression Quantitative recruited reference required Respiratory failure RPL6P27 SARS-CoV-2 Septic shock severe complication severity of COVID-19 SNP SNP association South Asian STK39 Supplemental oxygen therapy syndrome target tension THSD7B tissue United Arab Emirate university VWA8 [DOI] 10.1016/j.ebiom.2021.103695 [Article Type] Research article
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms백신 접종 전 단계에서 멕시코에서 SARS-CoV-2의 계통유전체학 및 인구유전체학은 관심 변이 B.1.1.28.4 및 B.1.1.222 또는 B.1.1.519 및 증상과 관련된 뉴클레오캡시드 돌연변이 S194L을 나타냅니다Research Articles Published on 2021-11-302022-09-10 Journal: Microbial Genomics [Category] MERS, SARS, 변종, 치료기술, 치료법, [키워드] adaptive addition allelic Analysis Asymptomatic Asymptomatic carriers baseline carrier clades Clinical data complementary COVID-19 pandemic disease dual E484K Effect Evolution Evolution of SARS-CoV-2 fixed Follow-up Frequency Genetic Genome genomes help highlight Host lack Mexico mitigate Mutation N-terminal domain nucleocapsid nucleocapsid protein Nucleocapsid proteins nucleotide pandemic phenotypic Phylogenomics population genomics pre-vaccination Prevalence Protein quantitative PCR raising receptor-binding motif Region reveal SARS-CoV-2 SARS-CoV-2 virus Single nucleotide variant single nucleotide variants spike and nucleocapsid proteins spike glycoprotein Spike protein Symptom symptomatic and asymptomatic Symptomatic patients T478K the SARS-CoV-2 virus understanding vaccination variant variants variants of interest virus [DOI] 10.1099/mgen.0.000684 PMC 바로가기 [Article Type] Research Articles
Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected산화 손상 및 지연된 복제로 인해 생존 가능한 결핵균이 발견되지 않음Article Published on 2021-11-242022-09-11 Journal: Science Translational Medicine [Category] SARS, 치료기술, [키워드] addition antimicrobial resistance Bacteria BCG cause of death Cell conditions coronavirus disease Coronavirus disease 2019 death DNA example implication Infection latency lipids mechanism Mycobacterium bovis Mycobacterium tuberculosis notable overcome oxidative stress pandemic phenotype phenotypic Proteins regimen regimens Relapse repair Replication Treatment Tuberculosis undergo undetectable [DOI] 10.1126/scitranslmed.abg2612 PMC 바로가기 [Article Type] Article
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19Tie2 활성화는 COVID-19의 혈전성 내피 기능 장애로부터 보호합니다Research Article Published on 2021-10-222022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] accompany Activation AKB-9778 alteration angiopoietin Anticoagulant Antithrombotic assessment Autopsy changes in circulating Coagulation Cohort Concentration COVID-19 demonstrated disease severity Disruption dysfunction endothelial Endothelial cell endothelial cells Endothelial dysfunction endothelial marker Endothelial markers expression Genes highest highlight Inflammation inhibit inhibited Microvascular thrombosis Mild moderate Patient patients with COVID-19 Pharmacologic phenotypic plasma procoagulant promoted property PROTECT prothrombotic prothrombotic state rationale receptor released reversed severe COVID-19 Signaling small molecule survival therapy These data thrombosis treated Trial upregulated Vascular Biology [DOI] 10.1172/jci.insight.151527 PMC 바로가기 [Article Type] Research Article
The metabolic roots of senescence: mechanisms and opportunities for intervention Reviews Published on 2021-10-192022-10-05 Journal: Nature metabolism [Category] 신약개발, [키워드] alteration cellular cellular metabolism cellular senescence change changes degenerative Effect effective intervention indicate inducer Intervention mechanism Metabolic diseases metabolic dysfunction metabolism mitigate phenotype phenotypic proliferative promote SASP senescent cell turn [DOI] 10.1038/s42255-021-00483-8 [Article Type] Reviews
Exome sequencing and analysis of 454,787 UK Biobank participantsArticle Published on 2021-10-182022-10-04 Journal: Nature [Category] 바이오마커, 유전자 메커니즘, [키워드] African Analysis Asian association associations Asthma Brain Cancer coding Cohort consequence Deleterious diabete disease European Exome exome sequencing FAM234A GBE1 gene function Genetics research Genome Genome-wide association studies GWAS Human genetics hypertension identify independent individual involved Liver disease loci loss-of-function MAP3K15 Missense participant Phenotypes phenotypic PLD1 protein-coding gene Rare variants Sequencing Sequencing analysis SLC27A3 SLC9A3R2 tested traits UK biobank underlie variant variants Variation [DOI] 10.1038/s41586-021-04103-z PMC 바로가기 [Article Type] Article