Dynamic metabolic changes measured by indirect calorimetry during the early phase of septic shock: a prospective observational pilot study Research Published on 2021-10-152022-10-05 Journal: European journal of clinical nutrition [Category] 바이오마커, [키워드] Analysis change changed collected criterion dynamic early phase eligible energy Evolution favor Final ICU intensive care lipids metabolic metabolism oxygen Patient Physiology pilot study Prospective Protein Proteins Quotient remained Result score Septic shock significant decrease significantly study period substrate substrates Support surgical time Variation Ventilated [DOI] 10.1038/s41430-021-01012-2 [Article Type] Research
mNUTRIC tool is capable to predict nutritional needs and mortality early in patients suffering from severe pneumoniaObservational Study Published on 2021-10-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] 95% CI Accuracy Admission Analysis APACHE II AUC value base calculated Care Chest CT chronic COVID-19 CURB-65 died discharged evaluate highest Hospitalization Hospitalized IBM initiated intensive care Intensive care unıt mNUTRIC. Mortality NRS-2002 nutrition nutritional need Organ failure pandemic Patient patients patients hospitalized Physiology positive predict prognostic retrospective reverse transcription PCR RT-PCR RT-PCR test severe pneumonia SOFA SPSS Statistics the patient Treatment was performed while [DOI] 10.1016/j.clnesp.2021.08.030 PMC 바로가기 [Article Type] Observational Study
The tiny effects of respiratory masks on physiological, subjective, and behavioral measures under mental load in a randomized controlled trial무작위 대조 시험에서 정신 부하 하에서 생리 학적, 주관적 및 행동 적 측정에 대한 호흡 마스크의 작은 효과Article Published on 2021-10-012022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 임상, [키워드] analyzed assumption blood oxygen level blood oxygen levels Blood oxygen saturation caused CLARITY clinical cognitive conditions conducted contribute coronavirus coronavirus disease COVID-19 debate dimension dimensions Effect Efficacy Face masks heart rate investigated Mask measure Mental open Open Science Framework outbreak oxygen participant Participants performed physiological Physiology Psychology public health Randomized controlled trial randomized-controlled Registered Respirator risk SARS-CoV-2 virus Science significant difference statistical the SARS-CoV-2 virus Transmission Trial Trial registration Variability [DOI] 10.1038/s41598-021-99100-7 PMC 바로가기 [Article Type] Article
Tocilizumab for the treatment of non-critical COVID-19 pneumonia: an overview of the rationale and clinical evidence to date중요하지 않은 COVID-19 폐렴 치료를 위한 토실리주맙: 현재까지의 근거 및 임상 증거 개요Review Published on 2021-10-012022-09-11 Journal: Expert review of clinical pharmacology [Category] MERS, SARS, 진단, 치료제, [키워드] Area benefit Clinical deterioration clinical evidence clinical trial clinical trials concomitant treatments COVID-19 COVID-19 pneumonia cytokine cytokine release Cytokine release syndrome Evidence expert Guidance immunomodulatory immunomodulatory therapy implication in some interleukin interleukin-6 investigated other disease other diseases pandemic pathophysiology patient selection patients with COVID-19 Physiology Pneumonia question rationale repurposed therapy systemic inflammation Tocilizumab Treatment [DOI] 10.1080/17512433.2021.1949286 PMC 바로가기 [Article Type] Review
Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling PipelinesSARS-COV-2 ORF8에서 168- 뉴클레오티드 결실의 다중 발생, 표준 앰플 리콘 시퀀싱 및 변형 호출 파이프 라인에 의해 눈에 띄지 않습니다.Article Published on 2021-09-182022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] Amplicon Amplicon sequencing amplicons analyzed ARTIC protocol classical coding region Consensus Data analysis database Deletion deletions ENA endemism Genome Genomic surveillance hospital hotspot identify infection chain infection chains investigated Lineage Local Multiple Mutation Nanopore nanopore sequencing nucleotide nucleotides ORF8 ORF8 deletion ORF8 gene outbreak Outbreaks pandemic Physiology Positive selection protocols raw data reported SARS-CoV-2 SARS-CoV-2 genome sequences SARS-CoV-2 pandemic SARS-CoV-2 sequence sequence Sequencing Standard the SARS-CoV-2 viral genomics virus virus genome [DOI] 10.3390/v13091870 PMC 바로가기 [Article Type] Article
Factors associated with inflamm-aging in institutionalized older peopleArticle Published on 2021-09-152022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] addition Analysis association Bioavailability biochemical biochemical marker Biomarkers Blood carried cluster analysis confidence level endothelial injury Factor fat greater HDL Health care high-density identify IL-6 increase in individuals Inflamm-aging Inflammation Inflammatory cytokine inflammatory state LDL Lipid low-density marker Older ordinal logistic regression Physiology presenting reduction in Risk factors risk of death sequence Sociodemographic three group TNF-α Triglyceride variable was performed was used [DOI] 10.1038/s41598-021-97225-3 PMC 바로가기 [Article Type] Article
Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch DataObservational Study Published on 2021-09-132022-10-04 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] A significant reduction age Analysis app Apple Watch autonomic baseline changes in Characteristics collected COVID-19 COVID-19 case COVID-19 diagnosis COVID-19 pandemic determine Effect emotion emotional enrolled Factor feature follow-up period HCW HCWs Health care worker heart rate heart rate variability highest hospital HRV identify increased risk individual longitudinal marker medium mental health Multivariate analysis nervous system nervous system function New York New York City objective Observational optimism pandemic participant Perceived stress physiological physiological consequence Physiology Protective Psychological Psychological distress Psychology Quality of life reduced risk Resilience Result risk significantly Stress Stressor subject Support survey Variability Warrior wearable device worker [DOI] 10.2196/31295 PMC 바로가기 [Article Type] Observational Study
Interactions between the Gut Microbiome, Lung Conditions, and Coronary Heart Disease and How Probiotics Affect These장내 미생물군집, 폐 상태, 관상동맥 심장병 간의 상호작용과 프로바이오틱스가 이들에 미치는 영향Review Published on 2021-09-082022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] Affect affecting can not cardiovascular disease chronic condition Clinical outcome Coronary Coronary heart disease COVID-19 COVID-19 infections disturbance effectors Factor Fatty acid fatty acids Gut gut microbiome gut–lung axis Health healthy heart Immune cell immune cells Interaction lung Lungs mechanism Microbiome occur organs other organ other organs Oxide Physiology Probiotics receptor responsible short-chain fatty acids Symptom to define variety [DOI] 10.3390/ijms22189700 PMC 바로가기 [Article Type] Review
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19Review article Published on 2021-09-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, [키워드] animal models Betacoronavirus Committee competitive binding controls correlated COVID-19 death Diseases distribution Efficacy H. pylori indicated Infectious disease Ivermectin mechanism Medicine Meta-analysis morbidity Mortality Mutant strains notable Physiology randomized clinical trial RCT RCTs reduction reductions in risk SARS-CoV-2 SARS-CoV-2 spike protein Seven Sharp Spike protein Treatment tropical yielding [DOI] 10.1016/j.nmni.2021.100924 [Article Type] Review article
CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseasesClinical Trial Published on 2021-08-262022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] Algorithms analysed Analysis approved asked carotid clinical study Clustering analysis coded contribute diabete diabetics Diagnosis disease early diagnosis ethics committee Glucose gold standard guidelines Health health informatics healthcare Healthcare systems ingestion interstitial Intervention metabolic disease metabolic disturbances Non-invasive Oxygen administration oxygen saturation participant Patient peer-reviewed peripheral chemoreceptor Physiology Predictive protocol protocols & quantification recent recruited respiratory rate response Result Stratification Therapeutic approach type 2 diabete ventilatory [DOI] 10.1136/bmjopen-2020-042825 PMC 바로가기 [Article Type] Clinical Trial