A dominant-negative mutant inhibits multiple prion variants through a common mechanism우성-음성 돌연변이는 공통 메커니즘을 통해 여러 프리온 변이체를 억제합니다Research Article Published on 2017-10-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amyloid cells chaperone chaperones clearance conformation conformational conformations curing daughter cells determine determined by disorders dominant-negative dosage doses Effect fiber human disease inhibit inhibited inhibitor inhibitors interfere Intervention kinetic Lower mechanism mode molecular mutant observation overcome pathway persistence phenotype Phenotypes plasticity prion Protein protein conformations reported resulting sensitivity shown specificity stability unique variant variants [DOI] 10.1371/journal.pgen.1007085 PMC 바로가기 [Article Type] Research Article
A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides비정규 RNA 분해 경로는 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이를 억제합니다Research Article Published on 2017-03-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation animal hosts Antifungal treatment Community component Compound conditions Degradation described determined by Dicer drug target drug-resistant effective Efficacy emerging disease ENhance environmental condition environmental conditions expression FK506 fungal Fungal infection fungal pathogen fungal pathogens fungi generate genetic analysis growth Helicase Host host-pathogen interaction host-pathogen interactions Human include inhibitory inhibitory effect involved isolate isolates lack mechanism molecular mechanism mRNA degradation Mucor Mucorale Mucorales Mucormycosis Mutation non-canonical RNA pathogen Pathogens pathway performed phenotype phenotypic plasticity prevented previous study Prognosis Protein provided RdRP recent Regulation represse Research RNAi RNAi pathway strain Strains stress conditions suppresse Target genes underlie [DOI] 10.1371/journal.pgen.1006686 PMC 바로가기 [Article Type] Research Article
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful AgingReview Published on 2016-11-242024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] CD16 CD56 cell senescence functional performance immune remodeling NKG2D plasticity TCR-independent [DOI] 10.3389/fimmu.2016.00530 PMC 바로가기 [Article Type] Review
Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.Research Article Published on 2016-10-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence [DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article
Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicityArticle Published on 2016-06-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition cellular membrane conserved coronavirus correlation Culture determine Ex vivo Extensive IBV induce Infectious Bronchitis Virus lab M41 membrane membrane vesicle Mild organ organelle pathogenic pathogenicity phenotype plasticity produced Region Replication replicative RNA spherule spherules strain Structure tested tracheal viral replication viral RNA synthesis virus viruses [DOI] 10.1038/srep27126 PMC 바로가기 [Article Type] Article
Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant GenotypesArticle Published on 2015-05-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Analysis association available data Belgium characterized circulating clinical sample Cluster collected Complete coronavirus Coronaviruses detect Diversity eight Epidemic Evolution FIVE France Genotype genotypes HCoV-OC43 Human human coronavirus identification information isolate Like Lower molecular N gene New Nsp12 OC43 Phylogeny plasticity provide recombinant Recombination respiratory infections responsible sequenced Sequencing specimen Temporal analysis TMRCA USA virus viruses [DOI] 10.3390/v7052358 PMC 바로가기 [Article Type] Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article
Fitness costs of disrupting circadian rhythms in malaria parasites말라리아 기생충의 일주기 리듬 방해에 따른 피트니스 비용Article Published on 2011-08-222024-08-14 Journal: Proceedings of the Royal Society B: Biological Sciences [Category] 말라리아, [키워드] Biological Rhythms cell cycle Periodicity Plasmodium chabaudi plasticity synchronicity [DOI] 10.1098/rspb.2010.2457 PMC 바로가기