Clinical Profiles and CMR Findings of Young Adults and Pediatrics with Acute Myocarditis Following mRNA COVID-19 Vaccination: A Case SeriesBrief Report Published on 2022-01-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence association cardiovascular Case series case sery characterized clinical clinically Colchicine Complication coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccines edema Ejection fraction female females Fever finding Follow-up healthy highlight Hospital stay Hospitalized involved Italy male males manifestation Marche messenger mRNA mRNA-based COVID-19 vaccine Myocardial myocarditis Myopericarditis one patient Patient Pediatric patients pediatrics preserved prevalent profile remained RNA second dose Sery Side effects Tachycardia treated Treatment treatment with colchicine vaccination Vaccine ventricular was performed [DOI] 10.3390/vaccines10020169 PMC 바로가기 [Article Type] Brief Report
Kinetics and persistence of cellular and humoral immune responses to SARS‐CoV‐2 vaccine in healthcare workers with or without prior COVID‐19이전 COVID-19 유무에 관계없이 의료 종사자의 SARS-CoV-2 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성Original Article Published on 2022-01-182022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, 변종, 진단, [키워드] antibody antibody levels baseline BNT162b2 BNT162b2 mRNA vaccine cellular cellular immune responses circulating viral variant conducted COVID‐19 death declining decrease descending diagnosed dose form healthcare worker Healthcare workers highest Hospitalization humoral immune response humoral responses IFN IFN‐γ IgA level IgA levels IgG antibodies immune response immune response post‐infection immune response post‐vaccination immune responses Infection Kinetics longitudinal study mRNA vaccine natural infection neutralization Neutralization assay Neutralizing activity Neutralizing antibodies new infections of BNT162b2 participant persistence preserved SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 infection secretion significantly spike‐specific CD4+ T cell spike‐specific CD8+ T cell subject T‐cell the disease titre Vaccine vaccine dose Viral waning immunity [DOI] 10.1111/jcmm.17186 PMC 바로가기 [Article Type] Original Article
Worldwide differences of hospitalization for ST-segment elevation myocardial infarction during COVID-19: A systematic review and meta-analysisCOVID-19 기간 동안 ST분절 상승 심근경색증으로 인한 전세계 입원의 차이: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-01-152022-09-11 Journal: International journal of cardiology [Category] SARS, 치료기술, [키워드] 95% CI acute coronary syndromes Admission article containment measures contributed Controlled controlled trials country COVID-19 COVID-19 pandemic disparity emergency medicine epidemiological data Epidemiology explain explained Factor healthcare Healthcare organization heterogeneity hospital Hospital admission Hospital admissions Hospitalization incidence investigator item Meta-analysis methodology Metrics Myocardial infarction no significant difference no significant differences Pandemics preserved Prospective public health random-effects model Registered registry reported Reporting review SARS-CoV-2 significantly STEMI systematic review systematic reviews Variability Variation [DOI] 10.1016/j.ijcard.2021.10.156 PMC 바로가기 [Article Type] Meta-Analysis
eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signalingArticle Published on 2022-01-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Activation ARDS Biomarker COVID-19 pandemic Cytokines DAMP dysregulation Evidence Extracellular genotyping IL-6 Inflammation Inflammatory inflammatory cascade inflammatory lung injury intravenous intravenously LPS lung Lung injury mAb molecular Mortality neutralization NFkB nicotinamide pathway plasma preclinical data Preclinical research preserved Protein reduce reduced reduction reduction in regulate Septic shock serum lactate severity Signaling signaling pathway significantly subjects Support therapy TLR4 TNFα unmet need Ventilator-induced lung injury [DOI] 10.1038/s41598-021-04444-9 PMC 바로가기 [Article Type] Article
Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection생존한 고령 환자들은 SARS-CoV-2 감염 후 수개월 동안 세포 및 체액 면역학적 기억이 보존됨을 보여줍니다Article Published on 2022-01-072022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-N antibodies anti-N antibody anti-N IgG anti-S anti-S IgG antibodies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determined by donors effective ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Fewer patient Fewer patients granzyme B had more heterogeneity hospital Humoral response IFN-γ IgG1 immune responses Immunity Immunological memory immunosenescence in some infected individuals Infection interferon interferon-γ life lymphocyte Lymphocytes memory memory B memory B cell memory B cells memory B lymphocytes memory T memory T lymphocytes Month Older pandemic Patient Peripheral blood positively correlated preserved producer cell quantified recovered patient reduce resolved respiratory respond response responses robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom show Specific specific antibodies specific immunity T lymphocyte T lymphocytes understanding Vaccination strategies virus were measured [DOI] 10.1093/gerona/glab206 PMC 바로가기 [Article Type] Article
Immune responses to mRNA vaccines against SARS-CoV-2 in patients with immune-mediated inflammatory rheumatic diseases면역 매개 염증성 류마티스 질환 환자에서 SARS-CoV-2에 대한 mRNA 백신에 대한 면역 반응Article Published on 2022-01-012022-09-12 Journal: RMD Open [Category] SARS, 진단, [키워드] abatacept age Autoimmune Autoimmune diseases B-cell CD4 CD8 Cellular immune response cellular response Cellular responses correlated COVID-19 cumulative deleterious effects demonstrated depleting dose drug Effect Efficacy elicited Gender glucocorticoid healthy controls humoral humoral responses identify immune response immune system immune system diseases Immune-mediated Immunosuppression immunotherapies infections Inflammatory introduced investigated leflunomide methotrexate mRNA mRNA vaccine mRNA vaccines naïve Patient patients with SARS-CoV-2 phase III trial preserved receiving reduce reduced responders response rheumatic disease rituximab SARS-CoV-2 SARS-CoV-2 vaccine selected Seroconversion seroconversion rate T-cell immune response T-lymphocyte subsets the vaccine Therapies therapy titre treated two-dose regimen vaccination Vaccine were excluded [DOI] 10.1136/rmdopen-2021-001898 PMC 바로가기 [Article Type] Article
MRI and CT coronary angiography in survivors of COVID-19Observational Study Published on 2022-01-012022-10-05 Journal: Heart (British Cardiac Society) [Category] 임상, [키워드] 95% CI abnormality Analysis blinded Comorbidities Comorbidity comparable Coronary artery disease COVID-19 COVID-19 disease severity CTCA demonstrated determine Ejection fraction elevated Extracellular fraction healthy healthy volunteer hospitalised intensive care IQR magnetic resonance imaging males median MRI Myocardial myocardial injury Patient preserved reduced remained reported survivor Symptoms Ventilated ventricular ventricular dysfunction Volume Volunteer widespread [DOI] 10.1136/heartjnl-2021-319926 PMC 바로가기 [Article Type] Observational Study
De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney DonorCase Report Published on 2021-12-272022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] BNT162b2 mRNA vaccine BNT162b2 vaccine change Complete Coronavirus disease 2019 COVID-19 COVID-19 vaccination de novo de novo glomerulonephritis Diagnosis disease Donor dosage Final glomerular initiated kidney kidney donor minimal change disease oral pandemic performed Pfizer/BioNTech Prednisolone preserved receiving renal function SARS-CoV-2 SARS-CoV-2 mRNA vaccines SARS-CoV-2 vaccination second dose syndrome the SARS-CoV-2 Vaccine vaccine dose [DOI] 10.3390/medicina58010037 PMC 바로가기 [Article Type] Case Report
Ecological surveillance of bat coronaviruses in Sarawak, Malaysian BorneoResearch Note Published on 2021-12-202022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] Amplicon bat bat coronavirus bat-CoV bats Bayesian posterior Betacoronavirus bootstrap cave clade collected Consensus coronavirus CoV CoVs Epidemic event Guano human coronaviruses island Lineage Malaysia maximum-likelihood Nature objective PCR primer phylogenetically preserved Probability RdRP reserve Result RNA-dependent RNA polymerase Sample Sanger method Sarawak screened sequenced specimen Surveillance transported unique Viral transport medium wind zoonotic [DOI] 10.1186/s13104-021-05880-6 PMC 바로가기 [Article Type] Research Note
Ecological surveillance of bat coronaviruses in Sarawak, Malaysian BorneoResearch Note Published on 2021-12-202022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, [키워드] Amplicon bat bat coronavirus bat-CoV bats Bayesian posterior Betacoronavirus bootstrap cave clade collected Consensus coronavirus CoV CoVs Epidemic event Guano human coronaviruses island Lineage Malaysia maximum-likelihood Nature objective PCR primer phylogenetically preserved Probability RdRP reserve Result RNA-dependent RNA polymerase Sample Sanger method Sarawak screened sequenced specimen Surveillance transported unique Viral transport medium wind zoonotic [DOI] 10.1186/s13104-021-05880-6 PMC 바로가기 [Article Type] Research Note