Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and ImmunomodulationReview Published on 2021-04-062022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] adjuvant Antigen approach B cell responses choice Combination component Critical Delivery system design Diseases effective Efficacy Establishing facilitate generate immune immune correlate immune response immunization immunological immunomodulation imperative knowledge life-threatening medical intervention memory Mortality preventing infection protection protective immune response rational route T cell time Vaccine vaccine antigen Vaccines [DOI] 10.3390/pharmaceutics13040501 PMC 바로가기 [Article Type] Review
Could Nanotheranostics be the Answer to the Coronavirus Crisis?Review Published on 2021-03-242022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] anti‐coronavirus Antiviral appraisals Bacterial China clinical trials coronavirus Coronaviruses COVID‐19 detect diagnose electrical electrospun facemasks Endosomal acidification fiber Hospital admission hydrophobicity inhibiting N95 respirators nanodiagnostics Nanoparticles offered pandemic preventing infection provide response Safety assessment Staphylococcus aureus treat viral replication [DOI] 10.1002/gch2.202000112 PMC 바로가기 [Article Type] Review
The impact of facemasks on emotion recognition, trust attribution and re-identificationArticle Published on 2021-03-102022-10-29 Journal: Scientific Reports [Category] Coronavirus, SARS, [키워드] Analysis emotion emotional Evidence expressions facemask facemasks help Human behaviour identity impair Mask Masks mechanism Pandemics preventing infection Psychology recognize significantly Social behaviour subsequent Support turn while [DOI] 10.1038/s41598-021-84806-5 PMC 바로가기 [Article Type] Article
Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/InactivationReview Published on 2021-02-222022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] advance agent Antiviral article assays bioactive compounds candidate Cell cell mechanisms coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 described detect Diagnosis Drug administration facial Future Health help human host inhibit main mechanism Masks measure mechanism media medication Nanocellulose Nanomaterial nanomedicine Novel coronavirus outbreak overcome pandemic Pathogenesis phytochemical Polymeric nanoparticles preventing infection public health emergency recent reduce Research retrieved review SARS‐CoV‐2 self‐cleaning surfaces Side effect silver nanoparticle Spread Surveillance systematic review therapy treat trend Vaccine Vaccines viral inactivation virucidal [DOI] 10.1002/gch2.202000115 PMC 바로가기 [Article Type] Review
Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody인간 단일 클론 항체를 중화하여 SARS-CoV-2 치명적인 감염된 K18-hACE2 형질 전환 마우스의 노출 후 보호Article Published on 2021-02-112022-09-12 Journal: Nature Communications [Category] MERS, 변종, 진단, [키워드] Ablation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered administration antibody approach caused consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection days post infection days post-infection disease symptom disease symptoms Efficacy Efficiency evaluate exhibit hACE2 human monoclonal antibodies Human monoclonal antibody in vivo Infection Infectious diseases infective K18-hACE2 transgenic mice life load lung Lungs mice monoclonal morbidity Mortality Neutralizing Neutralizing antibodies neutralizing antibody pandemic pathogen preventing infection rescued respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection sociality supported therapeutic treated Treatment virion [DOI] 10.1038/s41467-021-21239-8 PMC 바로가기 [Article Type] Article
Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2인플루엔자 바이러스 및 중증급성호흡기증후군 코로나바이러스 2에 대한 람다-카라기난의 항바이러스 활성Article Published on 2021-01-122022-09-10 Journal: Scientific Reports [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antiviral antiviral activity antiviral agent body weight broad spectrum cause Cell culture cell lysate cell lysates cell surface receptor cell surface receptors circulating Concentration coronavirus culture supernatant culture supernatants dose-dependent manner Drug discovery enveloped RNA viruses expression host cell host cells Influenza influenza A Influenza virus inhibited intranasal lambda-carrageenan macromolecule mice Microbiology Mortality plaque Plaque titration polysaccharide preventing infection progeny purified reduced reductions in respiratory respiratory diseases respiratory viruses RNA viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus sulfated suppressed Toxicity Viral viral challenge Viral protein Viral proteins virus virus entry virus production viruses western blot Western blot analysis [DOI] 10.1038/s41598-020-80896-9 PMC 바로가기 [Article Type] Article
The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized designRandomized Controlled Trial Published on 2021-01-012022-10-05 Journal: Contemporary clinical trials [Category] SARS, 임상, [키워드] 1:1 approach change changes in Cluster cluster design Cluster randomization Contact COVID-19 COVID-19 infection determine diagnosed Disease progression double-blinded early treatment High-dose Hospitalization household contacts include individual individuals with COVID-19 Infection Intervention Loading dose Mortality Occurrence Placebo Pragmatic preventing infection Primary outcome Prophylaxis provide Randomized reduce reducing risk risk of COVID-19 SARS-CoV-2 secondary outcome Seroconversion study outcome symptom severity score Trial Vitamin D Vitamin D supplementation [DOI] 10.1016/j.cct.2020.106176 PMC 바로가기 [Article Type] Randomized Controlled Trial
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] Activation acute respiratory syndrome animal Anti-spike antibody Antibody Response approach AZD1222 boost booster dose Booster vaccine cell activation cellular ChAdOx1 ChAdOx1 nCoV-19 clinical trials complement coronavirus coronavirus vaccine dose doses evaluated exploratory facilitate function functional antibody responses healthy homologous humoral immunogenicity data induce Infection Interim report magnitude multifunctional natural killer neutralizing antibody neutralizing antibody titers Open-label outcome phagocytosis phase Phase 3 Prevent preventing infection priming Randomized controlled trial receive reported Safe SARS-CoV-2 vaccine serology subgroup Support T cell response the vaccine Trial vaccination Vaccine viral spike protein Viral vector Volunteer [DOI] 10.1038/s41591-020-01179-4 [Article Type] Research
Characteristics and mechanisms to control a COVID‐19 outbreak on a leukemia and stem cell transplantation unitOriginal Research Published on 2020-12-122022-10-31 Journal: Cancer Medicine [Category] COVID-19, MERS, SARS, [키워드] acute myeloid leukemia adhere Allogeneic Antibody test Antibody testing autologous Characteristics Chemotherapy Clinical course Contact COVID‐19 COVID‐19 infection COVID‐19 infection diagnosed feature health‐care facilities hygiene immunocompromised individuals Immunosuppressed implementation Incubation period Infection Intensive leukemia lymphoma management of disease control Mask measure Measures mechanism mild symptoms outbreak Outbreaks Patient patients PCR positive Prevent preventing infection risk Stem cell transplantation subsequent symptomatic tested treated were infected without symptoms [DOI] 10.1002/cam4.3612 PMC 바로가기 [Article Type] Original Research
It is time to drop hydroxychloroquine from our COVID-19 armamentariumCOVID-19 무기고에서 하이드록시클로로퀸을 중단할 때입니다.Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 비임상, 신약개발, 임상, 치료제, [키워드] anti-SARS-CoV-2 activities Antiviral Blood breath cardiac toxicity catalyzed Chloroquine claimed conducted COVID-19 COVID-19 disease cumulative dose dosing regimens drug drug concentration Drug-drug interactions effective Efficacy epidemiological Evidence evidence of exhibited HCQ Hydroxychloroquine in vitro in vitro study in vivo increased risk influence interferon response lack mechanism media molecular mechanism molecular mechanisms observation observational studies observational study ongoing trial outcome Patient Perspective pharmacological preventing infection Prophylaxis randomized trial receive recruit SARS-COV-2 infection therapeutic potential Treatment treatment initiation widespread [DOI] 10.1016/j.mehy.2020.110198 PMC 바로가기 [Article Type] Article