pro-inflammatory cytokine – Page 6 – Communicable Diseases Research

Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade

Short communication

Published on 2022-04-012022-10-05
Journal: Biochemical and Biophysical Research Communication [Category] 신약개발,

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Research

Published on 2022-03-252022-10-05
Journal: Nature Immunology [Category] 비임상,

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도

Article

Published on 2022-03-252022-09-11
Journal: Cell Death & Disease [Category] SARS, 치료법,

[키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1
[DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article

Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19

치명적인 COVID-19의 조기 예측을 위한 바이오마커로서의 면역원성 SARS-CoV-2 S 및 N 단백질 펩티드 및 사이토카인 조합

Article

Published on 2022-03-212022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, 치료법,

[키워드] Activation analyzed Biomarker Biomarkers chemokines clinical outcomes convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sera cytokine Cytokine activation Cytokines demonstrated difference fatal fatal COVID-19 fatality higher risk highest humoral immune response IgG IgM IgM antibody improve clinical outcomes indication knowledge likelihood longitudinal analysis marker N protein nucleocapsid Nucleocapsid phosphoprotein Patient peptide peptides prediction pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines quantified reactivity risk S protein SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S selected serum serum sample serum samples severe coronavirus disease Surface glycoprotein Treatment
[DOI] 10.3389/fimmu.2022.830715 PMC 바로가기 [Article Type] Article

AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC

Research

Published on 2022-03-032022-10-29
Journal: Translational Medicine Communications [Category] COVID-19,

[키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19
[DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research

Blocking TNF signaling may save lives in COVID-19 infection

TNF 신호를 차단하면 COVID-19 감염에서 생명을 구할 수 있습니다

Review

Published on 2022-03-012022-09-11
Journal: Molecular biology reports [Category] SARS, 바이오마커, 신약개발,

[키워드] activated Activation anti-TNF binding blocking Blood blood clotting burst cascades clinical trials conditions consequence COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokine storm Cytokines death downstream drug effort Evidence Factor heart failure high mortality Hope IFNγ IL-6 immune therapy insulin insulin resistance involved kinase kinases lung damage mechanism mediator Medicine monoclonal antibodies monoclonal antibody multiple organ failure NFkappaB NFkB Organ failure Other other conditions pathogenic Prevent pro-inflammatory cytokine pro-inflammatory cytokines provided receptor resulting selected Severe case severe cases the disease therapy TNF TNF signaling Treatment strategies treatment strategy Tumor tumor necrosis tumor necrosis factor Tumor Necrosis Factor (TNF). vaccination
[DOI] 10.1007/s11033-022-07166-x PMC 바로가기 [Article Type] Review

Targeting TNF-α for COVID-19: Recent Advanced and Controversies

Public Health

Published on 2022-02-112022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, COVID19(2023년), SARS,

AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome

AKR1B10, SARS-CoV2 중증 급성 호흡기 증후군에서 사이토카인 폭풍의 방아쇠 중 하나

Article

Published on 2022-02-082022-09-10
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] Activation Acute respiratory failure AKR1B10 Analysis biological plausibility cell types contribute COVID-19 cytokine Cytokine storm Cytokines died drug treatment enzyme experiment expression extracellular vesicle Extracellular vesicles Factor form gene encoding highlight hospitalised COVID-19 patient hospitalised COVID-19 patients Hypothesis identify IL-1β IL-6 increased expression induce Inflammation inhibitor interleukin interleukin-1β interleukin-6 involved lipopolysaccharides LPS lung lung cells Macrophage macrophages management measurement modulation Occurrence outcomes over-expression Patient pharmacological target Preventing pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines Protein reduced reducing Reductase respiratory Respiratory failure SARS-CoV2 secreted sera severe forms of COVID-19 severity significantly storm systemic impact the cytokine storm the disease TNF α TNFα transcriptomic data transferred treated Trigger Tumor tumor necrosis tumor necrosis factor
[DOI] 10.3390/ijms23031911 PMC 바로가기 [Article Type] Article

Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients

SARS-CoV-2 감염 환자에서 심각한 COVID-19의 잠재적 예후 바이오마커로서의 Galectin-3

Observational Study

Published on 2022-02-032022-09-10
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술,

[키워드] 95% CI acute respiratory distress acute respiratory distress syndrome Admission Airway inflammation albumin allocation Analysis ARDS binding Biomarker characteristic clinician Combination contributing to correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CRP Cytokines D-dimer death defined determine discharge Evidence facilitate galectin-3 highest Hyperinflammatory IMV In-hospital death independent Invasive mechanical ventilation Logistic regression analysis marker multi-organ failure multivariable logistic regression Multivariable logistic regression analysis neutrophil neutrophil count neutrophil infiltration NLR Odds ratio outcome outcomes Patient predict Predictive markers pro-inflammatory cytokine pro-inflammatory cytokines prognostic prognostic biomarker receiver operating characteristic resource respiratory distress Respiratory distress syndrome risk ROC RT-PCR SARS-CoV-2 infected patient serum severe COVID-19 significantly syndrome viral infection
[DOI] 10.1038/s41598-022-05968-4 PMC 바로가기 [Article Type] Observational Study

Naltrexone a potential therapeutic candidate for COVID-19

Article

Published on 2022-02-012022-10-04
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발,

[키워드] ACE2 approved binding bioinformatics clinical coronavirus 2 Coronavirus infection COVID-19 COVID-19 patients Cytokines storm disrupt docking downstream Drug repurposing global pandemic glycoprotein host cells host receptor Hyperinflammatory induce inhibit inhibitor Interaction interfere Like lung tissue macrophage cell molecular molecular docking multiple organ failure naltrexone other coronaviruses Phosphorylation positively correlated pro-inflammatory cytokine pro-inflammatory cytokine release pro-inflammatory cytokine storm Protein RBD reported required respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection spike structural bioinformatics suppresse suppressed surface Spike tested the SARS-CoV-2 therapeutic therapy Toxicity Treatment viral entry viral infectivity viral replication virus load
[DOI] 10.1080/07391102.2020.1820379 PMC 바로가기 [Article Type] Article