An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variantsSARS-CoV-2에 대한 조작된 미끼 수용체는 단백질 S 서열 변이체에 광범위하게 결합합니다Research Article Published on 2021-02-172022-08-13 Journal: Science Advances [Category] Biochemistry, 변종, [키워드] ACE2 active against bats bind binding competing ectodomain escape favor followed by high affinity host cell host cell membrane Human Hypothesis in vitro Infection Mutagenesis mutant neutralize outbreak promise protein S receptor Receptor-binding domain receptors recognize sACE2 SARS-associated betacoronaviruses SARS-associated virus SARS-associated viruses SARS-CoV-2 SARS-related coronavirus saturation sequence similarity the receptor-binding domain variant Viral viral escape virus variant virus variants viruses wild-type [DOI] 10.1126/sciadv.abf1738 PMC 바로가기 [Article Type] Research Article
The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19COVID-19 감지를 위한 응집 유도 방출 발광체의 약속Review Published on 2021-02-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation aggregation-induced emission antibody assays bridge Chain Reaction coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect Detection sensitivity Diagnosis diagnostic emission exploration immunoassay immunological assay immunological assays infected individuals Luminescence nucleic acid offer pandemic polymerase chain reaction probe probes promise Quantitative researcher respiratory Reverse transcription-polymerase chain reaction RNA RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Small molecules virus water [DOI] 10.3389/fimmu.2021.635558 PMC 바로가기 [Article Type] Review
In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking분자 도킹을 통해 식품 공급원에서 잠재적인 항-COVID-19 생리활성 천연 성분의 실리코 스크리닝Article Published on 2021-02-012022-08-31 Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] MERS, SARS, 치료제, [키워드] 3CL 3CL pro ACE2 acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADME angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Autodock Vina software blackberry Chinese Chinese hawthorn and blackberry Compound content coronavirus COVID-19 distribution docking enzyme evaluated followed by Infection mechanism mechanism of action Medicine metabolism molecular docking outbreak Pharmacology Prevent promise Red Red wine respiratory SARS-CoV-2 SARS-CoV-2 3CL hydrolytic enzyme. selected severe acute respiratory syndrome Coronavirus speculation System Traditional Traditional Chinese medicine Virtual screening was determined [DOI] 10.1016/j.nut.2020.111049 PMC 바로가기 [Article Type] Article
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing HyperinflammationCOVID-19 및 Toll-Like Receptor 4(TLR4): SARS-CoV-2는 TLR4에 결합하고 활성화하여 ACE2 발현을 증가시켜 진입을 촉진하고 과염증을 유발할 수 있습니다Review Published on 2021-01-142022-09-10 Journal: Mediators of Inflammation [Category] 치료제, [키워드] ACE2 activate Activation alveolar cell antagonist Antiviral appear ARDS bind binding cause causes causing Cell cell surface cells clinical trial contribute COVID-19 COVID-19 patients Cytokines decrease entry receptor Evidence expressed expression Facilitating heart failure hyperinflammation Immune cell immune cells include increase Infection Inflammation Injury innate immune innate immune response interferons lung Lungs Mortality multiorgan failure multiple-organ myocarditis PAMPs pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogenesis pathogenesis of SARS-CoV-2 pathophysiological Proinflammatory cytokine proinflammatory cytokines promise protein-protein interaction Pulmonary surfactants receptor recognize reported Respiratory failure SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike glycoprotein secrete Sepsis severe COVID-19 significantly spike glycoprotein Spike protein surface tension tension the cell the SARS-CoV-2 the spike protein the strongest therapeutic target TLR4 Treatment Trigger triggers type I interferon type I interferons Viral Viral protein Viral proteins [DOI] 10.1155/2021/8874339 PMC 바로가기 [Article Type] Review
SARS-CoV-2/COVID-19 Vaccines: The Promises and the Challenges AheadEditorial Published on 2021-01-042022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] challenge promise [DOI] 10.3390/vaccines9010021 PMC 바로가기 [Article Type] Editorial
Fast automated detection of COVID-19 from medical images using convolutional neural networks컨볼루션 신경망을 사용하여 의료 이미지에서 COVID-19를 빠르게 자동 감지Article Published on 2021-01-042022-09-10 Journal: Communications Biology [Category] MERS, 진단, 치료기술, [키워드] automated auxiliary chest X-ray Clinical practice clinical settings Computational biology and bioinformatics Computed tomography Convolutional neural network coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection deep learning develop diagnose Diagnosis diagnostic diagnostic sensitivity diagnostic test Diseases feature FIVE global pandemic handling Health heatmap Heatmaps high accuracy identify Image processing IMPROVE infections Infectious diseases platform promise provide respiratory respiratory infections resulting sensitivity specificity specimen statistical upper respiratory X-ray [DOI] 10.1038/s42003-020-01535-7 PMC 바로가기 [Article Type] Article
Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virionsSARS-CoV-1 및 SARS-CoV-2 스파이크 유사형 쥐 백혈병 비리온을 사용한 중화 분석Methodology Published on 2021-01-042022-09-01 Journal: Virology Journal [Category] 진단, 치료기술, [키워드] Abbott antibody Antibody test antibody tests binding candidate vaccine capsid circumvent comparison Comparisons composed Concordance condition coronavirus COVID-19 detectable Euroimmun expressed firefly luciferase Genome IgG IgG test immunogenicity infected patient infected patients Influenza influenza infection Laboratory leukemia level 2 level 3 luciferase measure MLV murine Murine leukemia virus neutralization Neutralization assay neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing titers offer Particle Patient patients hospitalized plasma Prognostic factor promise pseudotyped Pseudotyped virus pseudovirion pseudovirions pseudovirus pseudoviruses R 2 ranged Receptor binding domain Replication replication-competent SARS-CoV-2 required Result SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum serum sample serum samples Siemen Siemens spike spike glycoprotein tested titers Viral diseases virion virus viruses [DOI] 10.1186/s12985-020-01472-1 PMC 바로가기 [Article Type] Methodology
Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implicationsWHO 데이터베이스에서 렘데시비르로 인한 의심되는 약물 부작용에 대한 신속한 검토 발견 및 시사점Article Published on 2021-01-012022-09-11 Journal: Expert review of clinical pharmacology [Category] SARS, 치료제, [키워드] ADE ADEs adverse drug events age America Americas Case report COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients creatinine Deterioration duplicate duplicates Effectiveness enzyme event Factor hepatic enzyme hepatic enzyme changes hepatic enzymes implication increase in Injury Kidney function liver liver and kidney function main outcome measure majority male management objective organ Patient patients with COVID-19 promise Rapid reduced regulatory authority Remdesivir renal renal injury reported Respiratory failure Result seriousness shown the WHO Vigibase® were excluded WHO [DOI] 10.1080/17512433.2021.1856655 PMC 바로가기 [Article Type] Article
Decontamination of SARS‐CoV‐2 contaminated N95 filtering facepiece respirators (FFRs) with moist heat generated by a multicooker멀티쿠커에서 발생하는 습열로 SARS-CoV-2로 오염된 N95 필터링 안면 마스크(FFR)의 오염 제거Original Article Published on 2020-12-312022-09-10 Journal: Letters in Applied Microbiology [Category] MERS, SARS, 치료기술, [키워드] approach approved authorization COVID‐19 criteria culture media decontamination Degradation demonstrated Efficiency effort Elasticity Emergency equipment EUA examined FIVE Impact inactivation limit of detection lung pandemic performed promise reduced Respirator Saliva SARS‐CoV‐2 SARS‐CoV‐2 virus shown Significance Steam STRAP Test tested These data titre Treatment was selected [DOI] 10.1111/lam.13443 PMC 바로가기 [Article Type] Original Article
Optical Biosensors for Virus Detection: Prospects for SARS‐CoV‐2/COVID‐19바이러스 검출을 위한 광학 바이오센서: SARS-CoV-2/COVID-19에 대한 전망Review Published on 2020-12-092022-09-10 Journal: Chembiochem [Category] MERS, SARS, 치료기술, [키워드] alternatives biosensor caused colorimetry coronavirus disease Coronavirus disease 2019 COVID-19 COVID‐19 detect diagnostics disadvantage Disadvantages equipment Fluorescence lack less Novel coronavirus novel coronavirus disease nucleic acid nucleic acid amplification optical optical biosensors pandemic Pathogens plasmons POC point‐of‐care promise scattering sensitivity surface plasmons tested Viral Viral detection virus virus detection [DOI] 10.1002/cbic.202000744 PMC 바로가기 [Article Type] Review