property – Page 6 – Communicable Diseases Research

Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Review

Published on 2021-06-112022-11-01
Journal: Foods [Category] COVID-19,

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern

우려되는 SARS-CoV-2 변이체에 대한 중화 항체의 에피토프 분류 및 RBD 결합 특성

Immunology

Published on 2021-06-042022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 binding ACE2 binding affinity acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis angiotensin angiotensin converting enzyme antibody bind binding binding affinity binding epitope C1D cause Cell classification concern coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID19 death disease disrupting E484K ENhance enzyme epitope mapping Epitopes evade evaluated exhibited Host immune response hosts interactions L452R less mutant N501Y NAb NAbs Naturally Neutralizing antibodies neutralizing antibody P.1 predict promote property Protein quantified RBD RBD binding RBD variant RBD variants Receptor binding domain representing respiratory responsible SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 WT sensitivity sequence variation Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Strains surface area susceptible susceptible hosts the RBD the SARS-CoV-2 therapeutic option Treatment variant variant of concern Viral viral infectivity viral pathogenesis while Wuhan-1
[DOI] 10.3389/fimmu.2021.691715 PMC 바로가기 [Article Type] Immunology

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

SARS-Cov-2 뉴클레오캡시드 단백질의 아르기닌 메틸화는 RNA 결합, 스트레스 과립 형성 억제 능력 및 바이러스 복제를 조절합니다

Research Article

Published on 2021-05-232022-09-10
Journal: The Journal of Biological Chemistry [Category] SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AP, affinity-purification arginine arginine methylation assembly binding blocked cancer treatment Cell culture clinical trial clinical trials component condensate coronavirus CTD, C-terminal dimerization domain defined DMSO, dimethylsulfoxide dose-dependent manner drugs FBS, fetal bovine serum Flag-N, Flag-epitope N protein G3BP1 genomic RNA GSK-3, glycogen synthase kinase 3 HEK293 cells hnRNPA1, heterogeneous nuclear ribonucleoprotein A1 host antiviral response host protein inhibited inhibiting inhibitor inhibitors Interaction life cycle lysine MERS-CoV, Middle East respiratory syndrome coronavirus methylarginine methylated Methylation methyltransferase motifs N protein N, nucleocapsid NTD, N-terminal RNA-binding domain nucleocapsid (N) protein nucleocapsid protein PAR-CLIP, photoactivatable ribonucleoside–enhanced crosslinking and immunoprecipitation PFA, paraformaldehyde PRMT1 PRMTs, protein arginine methyltransferases property Protein protein 3 RBP, RNA binding protein reduced regulate regulated required residue residues respiratory RGG/RG motif RIP, RNA immunoprecipitation RNA RNA binding S, spike SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequences severe acute respiratory syndrome Coronavirus SGs, stress granules significantly SMN, survival of motor neuron SR, serine/arginine-rich SRPK, SRSF protein kinase Stage Stress stress granule stress granules Substitution substrates suppress TDRD3, Tudor domain-containing protein 3 the N protein therapeutic Treatment Type type I type I PRMT inhibitor VeroE6 cell VeroE6 cells Viral viral genome viral life cycle Viral protein Viral proteins viral replication virion virions vRNP, viral ribonucleoprotein
[DOI] 10.1016/j.jbc.2021.100821 PMC 바로가기 [Article Type] Research Article

Genome-Wide Variation in Betacoronaviruses

Genetic Diversity and Evolution

Published on 2021-05-122022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antibody Antiviral antiviral drugs bat Betacoronavirus biological property Combination contributing to coronavirus COVID-19 Critical Defense diagnostic test diagnostic tests disorder Evolution form Genetic Genome genomic variation genus Betacoronavirus glycoprotein S highlight homologous Host host adaptation humans implication include infect Infection infection with SARS-CoV-2 manifested MERS-CoV Middle East Mutation natural new strain ORF1b ORF8 Other pathogenicity Probability profile property Protein protein S provide reliability repeated Replication respiratory syndrome coronavirus S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 strain selection pressure strain Strains Trigger Vaccine Vaccine design Variation virus
[DOI] 10.1128/JVI.00496-21 PMC 바로가기 [Article Type] Genetic Diversity and Evolution

The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical Application

Pharmacology

Published on 2021-05-072022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Actin Activation addressed allergenic anti-infammatory Anti-inflammatory anti-inflammatory agent anti-inflammatory effect Anti-viral anti-viral drug anti-viral effect antibody secretion Apoptosis appear application applied attenuate autophagy B-cell bird nest cellular Chinese traditional medicine clinical contaminant coronavirus COVID-19 cytokine cytokine secretion Defense Degradation derivative disease droplets drug edible bird’s nest Efficacy endosomal trafficking ENhance exacerbated Health highlighting host cells immunomodulatory effects IMPROVE in vitro in vivo models infected cells infections Influenza influenza A influenza infection lysosomal Nest Novel coronavirus oxidative pandemic Pathogenesis Pathogens Patient patients Potential pro-inflammatory cytokines proliferation property protective effect reduce replicated reported respiratory viral infections secretion severe symptom sialic acid suppresse therapeutic therapeutic effects transmitted treat Vaccine viral replication virus
[DOI] 10.3389/fphar.2021.633292 PMC 바로가기 [Article Type] Pharmacology

Vicarious Traumatization Questionnaire: Psychometric Properties Using Rasch Model and Structural Equation Modeling

Article

Published on 2021-05-062022-10-29
Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS,

Statistical Decision Properties of Imprecise Trials Assessing Coronavirus Disease 2019 (COVID-19) Drugs

Research article

Published on 2021-05-012022-10-05
Journal: Value in health : the journal of the International [Category] 임상,

Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus

SARS-CoV-2 코로나바이러스의 핵단백질을 표적으로 하는 NSAID 약물 나프록센의 항바이러스 특성

Article

Published on 2021-04-292022-09-10
Journal: Molecules [Category] SARS, 신약개발, 치료제,

[키워드] active against addition anti-inflammatory drug anti-inflammatory properties Antiviral antiviral properties antiviral property Antiviral treatment binding Celecoxib clinical setting clinical study coronavirus COVID-19 demonstrated drug Drug repurposing epithelia evaluated fluorescence anisotropy form function infected cells Inflammation Influenza influenza A influenza A virus inhibited inhibitor molecular naproxen nucleoprotein oligomerization pandemic Paracetamol predicted Prevent property respiratory respiratory epithelium SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection scattering Standard of care Structure-based drug design targeting tested the SARS-CoV-2 VeroE6 cell VeroE6 cells Viral viral replication virus
[DOI] 10.3390/molecules26092593 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

SARS-CoV-2 및 기타 인간 코로나바이러스 스파이크 단백질은 인간 기도의 온도 및 프로테아제에 맞게 미세 조정됩니다.

Research Article

Published on 2021-04-222022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘,

[키워드] activate activated Activation of SARS-2-S adaptive mechanism adaptive mechanisms adjusted airway adaptation airways alternative route authentic virus replication Author cathepsin L cathepsin L pathway cathepsin-rich cells caused cell tropism common cold common cold coronavirus contrary contributed coronavirus coronavirus spike protein coronavirus virulence coronaviruses SARS-CoV COVID-19 pandemic Critical D614 variant D614G mutation deletion mutants effective ENhance explain extended loop length feature furin furin recognition motif G614 variant HCoV HCoV-229E high transmissibility of SARS-CoV-2 highly pathogenic human airway human airways human coronaviruses human host human respiratory tract increase indicate intrinsic temperature preference loop deletion mutant loop deletion mutants lower airways mechanism MERS MERS-CoV mild common cold other coronavirus other coronaviruses pathogenic HCoV-229E virus pathology predominant processing produced promote property protease protease condition protease conditions Proteases Protein pseudoviruses pseudoviruses of SARS-CoV-2 replaced Replication respiratory respiratory tract S protein S protein stability S proteins S1/S2 cleavage loop SARS-2-S SARS-2-S-driven entry SARS-CoV SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 spike SARS-CoV-2 stability severe pneumonia significantly increased spike activator spike property Spike protein Spike proteins spike stability spike-D614 spike-G614 variant Spread surface protease surface proteases temperature temperature and protease conditions the S protein the SARS-CoV-2 the spike protein TMPRSS13 TMPRSS13 protease TMPRSS2 transmissibility of SARS-CoV-2 upper airways upper or lower airways Usage Viral viral spike protein virulent coronavirus virulent coronaviruses virus virus entry virus preference virus spread virus transmission Zoonotic introduction
[DOI] 10.1371/journal.ppat.1009500 PMC 바로가기 [Article Type] Research Article

Pneumonia Detection Using an Improved Algorithm Based on Faster R-CNN

더 빠른 R-CNN에 기반한 개선된 알고리즘을 사용한 폐렴 감지

Research Article

Published on 2021-04-212022-09-11
Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 치료제,