nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networksResearch Published on 2020-10-302022-10-31 Journal: Exrna [Category] COVID-19, [키워드] accompany Antigen presentation antigen-presentation approach Cell coronavirus 2 Diseases disorder drugs edema Factor Features Feed forward loops FFLs identify Infection Inflammatory response information loop miRNA miRNA coregulatory networks molecular molecular mechanism motif nSARS-CoV-2 pandemic pathophysiology pathway pulmonary disease Pulmonary edema regulate regulatory circuit regulatory network Research respiratory Result Signaling signaling pathway signaling pathways similarity Spread symptomatic targets TGF the disease thromboembolic thrombosis trajectory unique vaccine candidate viral replication virus virus spike protein while [DOI] 10.1186/s41544-020-00057-y PMC 바로가기 [Article Type] Research
Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress SyndromeReview Published on 2020-10-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Activation activity acute lung injury addition Appropriate ARDS attenuate cell entry cells changes in characterized COVID-19 Defense distress drug effective enzyme help humoral increased vascular permeability Inflammation Initially Injury lack pathogen’ Pathogenesis Pathogens Prognosis Pulmonary edema pulmonary fibrosis question RAS reducing renin–angiotensin system respiratory SARS-CoV-2 SARS-CoV-2 pandemic soluble ACE2 subject survival syndrome Therapeutic strategies therapeutic strategy tissue repair Treatment tumor necrosis factor-α [DOI] 10.3390/ijms21218038 PMC 바로가기 [Article Type] Review
Could aquaporin modulators be employed as prospective drugs for COVID-19 related pulmonary comorbidity?Article Published on 2020-10-012023-07-06 Journal: Med Hypotheses [Category] SARS, [키워드] aquaporin Aquaporin modulators COVID-19 Cytokine storm Inflammation Pulmonary edema [DOI] 10.1016/j.mehy.2020.110201 PMC 바로가기
COVID-19: In the Eye of the Cytokine StormImmunology Published on 2020-09-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” acute respiratory distress Administering aging Alleviating ARDS characterized Comorbidity condition COVID-19 COVID-19 case COVID-19 disease severity COVID-19 severity cytokine disorders drug dysregulated eye Factor hyperinflammation identify immune response immunomodulator immunosenecence immunosenescence imperative IMPROVE improvement Inflammation Inflammatory inflammatory state key factor knowledge Lungs MERS Mortality multi-organ failure other disease outcome overactive pathology Patient patients with comorbidities Prognosis Pulmonary edema reducing Research risk risk factor SARS-CoV-1 SARS-CoV-2 Sepsis severe COVID-19 storm the cytokine storm Therapeutic approach therapy with COVID-19 [DOI] 10.3389/fimmu.2020.558898 PMC 바로가기 [Article Type] Immunology
Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndromeResearch Letter Published on 2020-09-242022-11-01 Journal: Critical Care [Category] Coronavirus, SARS, [키워드] acute respiratory distress COVID-19 Critical care Critically ill patient Immunomodulatory agents peptide Pulmonary edema Respiratory distress syndrome, adult syndrome Therapies, investigational Treatment [DOI] 10.1186/s13054-020-03293-8 PMC 바로가기 [Article Type] Research Letter
Heterogeneous Perfusion in COVID-19 and High Altitude Pulmonary Edema: A Review of Two Cases Followed by Implications for Hypoxic Pulmonary Vasoconstriction, Thrombosis Development, Ventilation Perfusion Mismatch and Emergence of Treatment ApproachesInfectious Disease Published on 2020-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] altitude blocker Case report Clinical course Clinical finding Clinical findings condition Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 disease COVID-19 management covid-19 respiratory failure described development emergence finding followed by heterogeneous high altitude pulmonary edema hypoxia hypoxic hypoxic injury hypoxic pulmonary vasoconstriction implication IMPROVE improved mortality laboratory parameter mechanism medication mismatch Multiple outlined Oxygenation pathophysiologic pathophysiology Patient patients patients with COVID-19 Perfusion Prevent promoted provide pulmonary Pulmonary edema pulmonary vasodilation reported responses review sars-cov-2 (severe acute respiratory syndrome coronavirus -2) similarity Support therapy treat treated treatment regimen treatment strategy Vascular vasodilatation vasodilator ventilation perfusion mismatch [DOI] 10.7759/cureus.10230 PMC 바로가기 [Article Type] Infectious Disease
Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2Research Published on 2020-06-192022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect affected angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Anhydrase appear application approach association biochemical pathway Biology Blood blood circulation Carbonic anhydrases (CAs) caused cellular Chest complex Concentration coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient death deaths diarrhea disorder dry cough expected facilitated fatigue Fever fibrosis finding functions highest Infection Inflammation information key factor less loss of taste Lungs membrane metallo-endopeptidase MME neprilysin organ Pain pathogenesis of SARS-CoV-2 Pulmonary edema Quality of life RAS receptor reduction in renal Renin Angiotensin System (RAS) respiratory acidosis Result SARS-CoV-2 skin rashe Symptom System System biology the United State therapeutic strategy to define Treatment virus virus pathogenesis [DOI] 10.1186/s12575-020-00124-6 PMC 바로가기 [Article Type] Research
Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients코로나19 환자를 위한 지방유래 중간엽줄기세포의 임상적 사용 근거Review Published on 2020-05-182022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome administration alveolar fluid clearance animal model animal models antimicrobial ARDS ASC benefit breath capital city Cell China Clinical studies clinical study Clinical use Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 outbreak COVID-19 patient Critical demonstrated distress edema effective Ex vivo Fever global pandemic globe greater Health Organization healthcare high mortality rate hospital resources human clinical trials human lung hypoxia illness immune response immune responses immunomodulatory activities in some in vivo Inflammation inhibit intravenous Intravenous administration intravenous route lead Local lung lung damage Lungs majority Mesenchymal stem cells molecules morbidity morbidity and mortality MSC MSCs multi-organ failure Multiple Novel coronavirus older patients Pain Patient patient mortality per day Pneumonia pulmonary disease Pulmonary edema Pulmonary function rationale reduce reduced respiratory respiratory distress respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection severe disease Severe respiratory distress stem cell stem cells syndrome therapeutic option therapy Travel Treatment treatment of COVID-19 Viral viral outbreak viral respiratory with COVID-19 World Health Organization Wuhan [DOI] 10.1186/s12967-020-02380-2 PMC 바로가기 [Article Type] Review
A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?Review Published on 2020-05-132022-10-28 Journal: Pulmonary Therapy [Category] COVID-19, [키워드] ACE2 acute respiratory distress Angiotensin receptors antagonists anti-IL-6 antiviral therapy approval ARDS benefit bradykinin complement Contact contact system convalescent plasma coronavirus coronavirus pathogenesis Corticosteroids COVID-19 cytokine Cytokine storm death defined edema effective enzyme etiology Evidence Human Hydroxychloroquine include increase in Intervention investigated knockout mice less Lung disease manuscript mice mouse model office Pathogenesis Pneumonia Potential treatment protection Protective Pulmonary edema receptor Result risk role SARS-CoV SARS-CoV-2 searched syndrome System the disease therapeutic intervention Treatment viruses wild-type [DOI] 10.1007/s41030-020-00118-5 PMC 바로가기 [Article Type] Review
Mesenchymal stem cells as a potential therapy for COVID-19Commentary Published on 2020-05-042022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, [키워드] 2019 novel coronavirus ALI ARDS cause cellular characterized clinical trial COVID-19 Critical disease distress effective hyaline membrane formation Inflammatory response lung mesenchymal stem cell MSC MSCs outbreak pathologic feature potential therapy presenting Pulmonary edema pulmonary inflammation raise Severe case specific treatment syndrome therapy Treatment [DOI] 10.1186/s13287-020-01678-8 PMC 바로가기 [Article Type] Commentary