Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasmaResearch Article Published on 2021-03-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] active against acute respiratory syndrome antimalarial drug blood sample clinical study conditions coronavirus COVID-19 pandemic develop development Dilution emergency response ESI freeze-thaw cycles HCQ Human plasma Hydroxychloroquine injected Ion LC-MS/MS system less Liquid chromatography m/z matrix effect metabolite metabolites normalized overcome pandemic quantification quantitation ranged reported Result Sample SARS-CoV-2 selected Tandem mass spectrometry temperature Total Volume was used were used [DOI] 10.1371/journal.pone.0247356 PMC 바로가기 [Article Type] Research Article
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19순환하는 미토콘드리아 DNA는 COVID-19로 인한 중증 질병 및 사망률의 초기 지표입니다Clinical Medicine Published on 2021-02-222022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, 진단, [키워드] Admission age assessment Care circulating circulating cell clinical clinically collected Comorbidities complement COVID-19 COVID-19 therapy damaged died DNA elevated funding hospital ICU ICU admission immunology independent independent of independent risk factor Inflammation Inflammatory Inflammatory marker intensive care unit intrinsically intubation marker measure Mitochondria mitochondrial mitochondrial DNA Mortality multivariate multivariate regression analysis NIH nucleic acid nucleic acids outcome outcomes Patient plasma sample plasma samples predict Primary outcome Program quantitation receiver operating characteristic released renal replacement therapy replacement therapy reported required Result risk Risk factors Science Secondary outcomes Sex solid organs subject target therapy Undetermined university Vasopressor Washington were used with COVID-19 [DOI] 10.1172/jci.insight.143299 PMC 바로가기 [Article Type] Clinical Medicine
Rapid electrochemical detection of coronavirus SARS-CoV-2코로나바이러스 SARS-CoV-2의 신속한 전기화학적 검출Article Published on 2021-02-052022-09-10 Journal: Nature Communications [Category] MERS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amplicon caused clinical samples Complete Concordance contagious contagious disease coronavirus coronavirus disease Coronavirus disease 2019 coronavirus SARS-CoV-2 correlation COVID-19 COVID-19 diagnosis detect detectable diagnostic diagnostic test disease Genes hybridization isothermal less Oligonucleotide probes Other respiratory viruses positive probe probes qRT-PCR quantitation Quantitative Rapid RCA respiratory respiratory viruses reverse transcription PCR Rolling circle amplification SARS-CoV-2 sensor sensors severe acute respiratory syndrome Coronavirus time-consuming [DOI] 10.1038/s41467-021-21121-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2-reactive interferon-γ-producing CD8+ T cells in patients hospitalized with coronavirus disease 2019코로나바이러스 질병 2019로 입원한 환자의 SARS-CoV-2 반응성 인터페론-γ 생성 CD8+ T 세포Article Published on 2021-01-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] acute respiratory syndrome Amino acid antibody antigenic blood cell count CD4+ CD8+ CD8+ T cell CD8+ T cells CD8+ T-cell Clinical course comparable coronavirus coronavirus disease correlation COVID-19 detectable detection rate determine displaying entire sequence expressing flow-cytometry form Frequency glycoprotein hospitalized patient IFN-γ Immunoglobulin inflammatory biomarkers information intensive care interferon-γ intracellular cytokine staining M protein median microbiologically N-terminal no correlation overlapping Patient patients hospitalized patients with moderate peptide producing prognostic quantitation responses SARS-CoV-2 SARS-COV-2 infection sequence spike subset T-cell T-cell immune response T-cell immunity tested the disease the SARS-CoV-2 were used [DOI] 10.1002/jmv.26213 PMC 바로가기 [Article Type] Article
Efficacy of povidone-iodine to reduce viral loadComment Published on 2020-11-012023-07-11 Journal: Oral diseases [Category] SARS, [키워드] COVID-19 povidone-iodine quantitation respiratory SARS-CoV-2 [DOI] 10.1111/odi.13557 PMC 바로가기 [Article Type] Comment
Assessment of the direct quantitation of SARS-CoV-2 by droplet digital PCRArticle Published on 2020-10-302022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV CDC amplification applied approach approaches assessment automated Calabria Care Cohort collected described digital PCR droplet evaluate extracted RNA heat inactivation inactivated independent IRCCS Italy medium N1 and N2 Nasopharyngeal swab pandemic performed purification quantitation Region RNA copy RNA extraction RNA purified RPP30 SARS-CoV-2 SARS-CoV-2 patients sensitivity Sensitivity and specificity specificity Swab Treatment triplex UTM Veneto viral infection viruses was used were used [DOI] 10.1038/s41598-020-75958-x PMC 바로가기 [Article Type] Article
Determination of telbivudine in the plasma of chronic hepatitis B patients in long-term treatment by high-performance liquid chromatographic-tandem mass spectrometryArticle Published on 2018-04-012023-06-19 Journal: Biomedical chromatography : BMC [Category] B형 간염, [키워드] creatine kinase Mitochondrial toxicity Myopathy pharmacokinetics quantitation telbivudine [DOI] 10.1002/bmc.4140
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated StrainArticle Published on 2016-11-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Attenuated carried change Comparative diarrhea epidemic diarrhea eukaryotic expressed groups Heat shock heterogeneous immune system Infection inoculated Interaction interferon-stimulated gene involved ISGs iTRAQ Jejunum labeling Laboratory mechanism Mortality nuclear organ Pathogenesis pathogenicity PEDV Porcine epidemic diarrhea virus predominant produced Protein proteomic quantitation quantitative proteome analysis response responses responsible ribonucleoprotein Signal transduction strain Strains Stress tissue up-regulated virulent virus [DOI] 10.3390/v8120323 PMC 바로가기 [Article Type] Article
Role of serum hepatitis B virus marker quantitation to differentiate natural history phases of HBV infectionArticle Published on 2016-01-012023-06-19 Journal: Hepatology international [Category] B형 간염, [키워드] differentiation Hepatitis B virus marker Infection natural history quantitation [DOI] 10.1007/s12072-015-9657-6
Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea VirusMethodology Article Published on 2015-08-012022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] addition Analysis antibody Asia asked assays biotinylated calculated colostrum Coronaviruses correlation country cross-reactivity demonstrated described develop development diagnostic test Disadvantages ELISA epidemic diarrhea expressed fluorescent Fluorescent Focus Neutralization (FFN) Fluorescent microsphere immunoassay (FMIA) functional gastroenteritis highlight IFA Immune status immunoassay immunohistochemistry Interpretation kappa value Laboratory mAb mAbs magnetic bead measurement microsphere MONITOR monoclonal monoclonal antibody multiple antigen naïve Neutralization assay Neutralizing antibodies neutralizing antibody Neutralizing antibody response North North America outbreak pathogen PEDV porcine epidemic diarrhea virus (PEDV) protective immunity quantitation question receiver operating characteristic recent Respiratory Coronavirus Result ROC ROC analysis Sensitivity and specificity Seroconversion Serological assay serology serum serum sample significant level Spread staining strain TGEV vaccine candidate virus virus neutralizing antibodies was performed were used [DOI] 10.1186/s12917-015-0500-z PMC 바로가기 [Article Type] Methodology Article