Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – Coalition V): A double-blind, multicentre, randomised, controlled trialResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 신약개발, 임상, 치료법, [키워드] 1:1 Analysis benefit Brazil Chloroquine Clinical deterioration Coalition complement conducted Controlled trial COPE COVID-19 COVID-19 patient did not reduce double-blind Enrollment events finding form funding hospitalisation Hydroxychloroquine Infection intention-to-treat ITT matching placebo Meta-analysis Mild mITT analysis moderate molecular multicenter multicentre no significant difference non-hospitalised Outpatient participants with SARS-CoV-2 Patient patients with COVID-19 Placebo placebo group positive precluded presenting Primary outcome randomised Randomly RCT receive reducing Registered risk risk factor serology testing Seven Statistical power suggested Support Symptom Treatment treatment allocation Trial use of hydroxychloroquine was performed [DOI] 10.1016/j.lana.2022.100243 [Article Type] Research article
Efficacy and Safety of Lianhua Qingwen for Patients with COVID-19: A Systematic Review and Meta-AnalysisCovid-19 환자를위한 Lianhua Qingwen의 효능 및 안전성 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-012022-08-31 Journal: Chinese journal of integrative medicine [Category] 치료제, [키워드] 2019-nCoV Adverse reaction Analysis China Chinese Chinese medicine Computed tomography conducted control group Corona virus cough COVID-19 Data analysis database disease drug effective Efficacy and safety evaluate expectoration experimental group Express fatigue Fever followed by Intervention lianhua qingwen measure Meta-analysis nCoV outbreak outcome measures participant Randomized controlled trial Randomized controlled trials RCT RCTs researchers respiratory Retrospective study review risk of bia Safety scale Shortness of breath Spread subgroup analysis Symptoms systematic review treat treating COVID-19 treating COVID-19 patient Treatment treatment methods Trial trials Virus Disease was used were assessed with COVID-19 [DOI] 10.1007/s11655-022-3578-8 PMC 바로가기 [Article Type] Meta-Analysis
Effect of Pulmonary Rehabilitation Approaches on Dyspnea, Exercise Capacity, Fatigue, Lung Functions, and Quality of Life in Patients With COVID-19: A Systematic Review and Meta-analysisReview article Published on 2022-07-012022-10-05 Journal: Archives of physical medicine and rehabilitation [Category] 임상, [키워드] 6-minute walk test 6MWT6-minute walk test 95% CI acute COVID-19 appear Capacity chronic obstructive pulmonary disease Controlled trial COPDchronic obstructive pulmonary disease COVID-19 COVID-19 patients database Dyspnea Effect effective evaluate the effect evaluated exercise Exercise capacity extraction fatigue feasible forced vital capacity functions FVCForced vital capacity independent indicate Intervention life lung Lung function mean difference Mild mild symptoms objective outcome outcome measure participant Patient patients with COVID-19 PRpulmonary rehabilitation pulmonary pulmonary rehabilitation QoLquality of life Quality Quality of life random effect Randomized controlled trial RCT RCTrandomized controlled trial RCTs review risk of bia Safe searched Selection severe symptoms SFShort-Form Health Survey SGRQSt. George's Respiratory Questionnaire Short-Form Health Survey significantly SMD Source St. George's Respiratory Questionnaire synthesis ventilatory Web of Science [DOI] 10.1016/j.apmr.2022.06.007 [Article Type] Review article
Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID-19 Requiring invasive ventilation Meta-Trial (CHARTER-MT): Protocol and statistical analysis plan for an investigator-initiated international meta-trial of prospective randomised clinical studies분무형 HepArin이 침습적 인공호흡이 필요한 COVID-19 환자의 사망률과 발관까지의 시간을 줄일 수 있습니까?Article Published on 2022-07-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] COVID19(2023년), SARS, 임상, [키워드] Activation alveolar fibrin Analysis Anti-inflammatory ARDS blinded Can clinical study clinical trial Coagulation controlled clinical trials country COVID-19 COVID-19 pneumonia dataset days alive defined Effect endpoints Evidence extubation FIBRIN FIVE heparin hypoxaemic respiratory failure Infection Inhaled International invasive ventilation investigator-initiated Laboratory limit lung Lung injury mammalian cells meta-trial Microvascular thrombosis nebulised heparin open label pandemic patient data patients with COVID-19 Placebo placebo-controlled Pneumonia Prevent Primary outcome progression randomised randomised controlled randomised study RCT receive Respiratory failure resulting SARS SARS-CoV-2 SARS-CoV-2 virus standard care Statistical analysis plan the SARS-CoV-2 virus therapy thrombosis unfractionated heparin ventilator-free day Ventilator-free days with COVID-19 [DOI] 10.1111/bcp.15253 PMC 바로가기 [Article Type] Article
Effect of Tocilizumab, Sarilumab, and Baricitinib on Mortality Among Patients Hospitalized for COVID-19 Treated with Corticosteroids: A Systematic Review and Meta-AnalysisReview article Published on 2022-07-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] 임상, [키워드] aggregate all-cause mortality average Baricitinib Bayesian Bia certainty of evidence Cochrane Library Controlled trial Corticosteroid Corticosteroids COVID-19 Effect eligibility criteria Evidence greater Hospitalized hospitalized COVID-19 hospitalized COVID-19 patients margin medRxiv Meta-analysis meta-regression moderate Mortality objective Odds ratio outcome participant Patient patients treated Placebo Probability ranged RCT receiving reduction reductions in required Result review risk of bia sarilumab Standard of care Tocilizumab treated Treatment were used with COVID-19 [DOI] 10.1016/j.cmi.2022.07.008 [Article Type] Review article
Weight Management Interventions Provided by a Dietitian for Adults with Overweight or Obesity: An Evidence Analysis Center Systematic Review and Meta-AnalysisResearch article Published on 2022-07-012022-10-05 Journal: Journal of the Academy of Nutrition and Dietetics [Category] 비임상, [키워드] 95% CI analyses assessment blood pressure body mass index cardiometabolic Care center certainty of evidence CINAHL Cochrane Central Comorbidity components conditions conducted database determine development Diastolic blood pressure Dietitian Efficacy eligible English language Evidence examined form funnel plot Health heterogeneity International Intervention management mean difference Mental Meta-analysis moderate Nutrition therapy obesity objective outcome overweight physical provided PsycINFO Quality of life random-effects model Randomized controlled trial RCT RCTs Registered Result review Risk of bias searched survey systematic review Systolic blood pressure usual care Version Waist circumference was used weight weight loss [DOI] 10.1016/j.jand.2022.03.014 [Article Type] Research article
Comparability of clinical trials and spontaneous reporting data regarding COVID-19 vaccine safety Research Published on 2022-06-292022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] Adverse adverse event AEs anaphylaxis calculated clinical trial Cohort COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine trial first dose FIVE Follow-up highest inherent biase janssen limitation Local Moderna MONITOR myocarditis Pfizer Randomized controlled trial RCT RCTs reported Reporting risk second dose severe AE severe AEs shingle single dose Surveillance System systemic AE systemic AEs thrombosis Vaccine vaccine dose vaccine group Vaccines were assessed [DOI] 10.1038/s41598-022-13809-7 [Article Type] Research
Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analysesRandomized Controlled Trial Published on 2022-06-272022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] acid acquisition acute respiratory syndrome adaptive Admission Analysis Bayesian Bayesian analysis Bayesian method coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case determine Effect effective Efficacy expected fixed Follow-up futility greater had no hazard ratio HCQ HCW healthcare worker hospitalisation Hydroxychloroquine imperative Infection intensive care International Intervention Ireland less log mechanical ventilation Mortality multicentre New occur occurred Open-label outcome pandemic Pandemics parallel-group participant Pathogens posterior probability Pragmatic primary endpoint proceed Prophylactic Prophylaxis randomised randomised controlled trial RCT recruitment reducing reduction in risk Sample size SARS-CoV-2 SARS-COV-2 infection secondary shown Stopping Treatment Trial Trial registration variable [DOI] 10.1186/s13063-022-06402-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Ivermectin for preventing and treating COVID-19COVID-19 예방 및 치료를 위한 이버멕틴Review Published on 2022-06-212022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission adverse event adverse events all-cause mortality antiparasitic Antiviral approach ARMS Asymptomatic certainty certainty of evidence citation classification Clinical improvement clinical trial Cochrane COVID-19 Study Register coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 symptoms COVID-19 treatment Data collection database death discharged disease disease severity double-blind duration of symptom early stage early stages Efficacy Efficacy and safety eligible Evidence excluded for inclusion GRADE hospital identify in vitro include increase index Infection infection with SARS-CoV-2 inhibit inhibitory effect initial symptom Inpatient Inpatients Intervention Invasive mechanical ventilation investigated Ivermectin life mean difference Mental Meta-analysis Mild Moderate COVID-19 moderate-to-severe COVID-19 molecular hypothesis Mortality no effect non-randomized ongoing trial ongoing trials Open-label outcome Outpatient outpatients participant Participants people with COVID-19 physical Placebo placebo-controlled Postexposure Prophylaxis Prevent Quality of life question Randomized controlled trial Randomized controlled trials RCT RCTs receiving reduce Registered Replication Reporting request Research resolved risk Risk of bias risk ratio RoB 2 SARS-CoV-2 SARS-COV-2 infection Science Citation Index searched Selection Serious Adverse Event Serious Adverse Events Seven severe acute respiratory syndrome Coronavirus Standard of care treat treated treating COVID-19 Treatment Trial trials viral clearance virus Web of Science WHO WHO guideline worsening [DOI] 10.1002/14651858.CD015017.pub3 PMC 바로가기 [Article Type] Review
Protocol for an attention-matched randomized controlled trial of 2GETHER: a relationship education and HIV prevention program for young male couples2GETHER의 관심 일치 무작위 대조 시험 프로토콜: 젊은 남성 커플을 위한 관계 교육 및 HIV 예방 프로그램Article Published on 2022-06-202022-09-11 Journal: Trials [Category] 임상, [키워드] acceptability Affect Chicago composed control condition COVID-19 pandemic detect Effect Efficacy enrolled Epidemic feasibility Follow-up Health healthy HIV HIV prevention impacted incidence individuals Infection male men occur occurred outcome outcomes positive post-intervention prevention program Program promote Randomized Randomized controlled trial RCT recruitment robust Sex sexually transmitted infection Social support study outcomes Support transmitted Trial USA [DOI] 10.1186/s13063-022-06457-9 PMC 바로가기 [Article Type] Article